Photo of Tanzil Arefin

Tanzil Arefin

Assistant Research Professor


  • Biomedical Engineering

W302 Millennium Science Complex





  • B.Sc. in Electrical and electronic Eniginering, Image Processing, Islamic University of Technology (IUT), 2007
  • M.Sc. in Biomedical Engineering, Biomedical Imaging, University of Groningen, 2012
  • M.Sc. in Biomedical Engineering, Biomedical Imaging, Czech Technical University, 2013
  • PhD in Neuroscience, Neuroscience/ Neuroimaging, University of Freiburg, 2017
  • PhD in Neuroscience, Neuroscience/ Neuroimaging, University of Strasbourg, 2017


Journal Articles

  • Zifei Liang, Tanzil Arefin, Choong Lee and Jiangyang Zhang, 2023, "Using Mesoscopic Tract-Tracing Data to Guide the Estimation of Fiber Orientation Distributions in the Mouse Brain from Diffusion MRI", Neuroimage, 270, pp. 119999
  • Zifei Liang, Choong Lee, Tanzil Arefin, Zijun Dong, Piotr Walczak, Song-Hai Shi, Florian Knoll, Yulin Ge, Leslie Ying and Jiangynag Zhang, 2022, "Virtual mouse brain histology from multi-contrast MRI via deep learning", Elife, 11, pp. e72331
  • Tanzil Arefin, Laetitia Degiorgis, Sami Ben Hamida, Vincent Noblet, Cristina Antal, Thomas Bienert, Marco Reisert, Dominik von Elverfeldt, Brigitte Kieffer and Laura-Adela Harsan, 2022, "Translational structural and functional signatures of chronic alcohol effects in mice", Biological Psychiatry, 91, (12), pp. 1039-1050
  • Tanzil Arefin, Choong Lee, Jordon White, Jiangynag Zhang and Arie Kaffman, 2021, "Macroscopic Structural and Connectome Mapping of the Mouse Brain Using Diffusion Magnetic Resonance Imaging", Bio-protocol, 11, (22), pp. e4221-e4221
  • Jordon White, Tanzil Arefin, Alexa Pugliese, Choong Lee, Jeff Gassen, Jiangynag Zhang and Arie Kaffman, 2020, "Early life stress causes sex-specific changes in adult fronto-limbic connectivity that differentially drive learning", Elife, 9, pp. e58301
  • Tanzil Arefin, Chaoyi Zhang, Ukash Nakarmi, Choong Lee, Hongyu Li, Dong Liang, Jiangyang Zhang and Leslie Ying, 2020, "Acceleration of three-dimensional diffusion magnetic resonance imaging using a kernel low-rank compressed sensing method", NeuroImage, 210
  • Tanzil Arefin, Gregoire Maroteaux, Laura-Adela Harsan, Emmanuel Darcq, Sami Ben-Hamida and Brigitte Kieffer, 2018, "Lack of anticipatory behavior in Gpr88 knockout mice showed by automatized home cage phenotyping", Genes, Brain and Behavior, 17, (8)
  • Sami Ben Hamida, Sueli Mendonça-Netto, Tanzil Arefin, Taufiq Nasseef, Laura-Joy Boulos, Michael McNicholas, Aliza Ehrlich, Eleanor Clarke, Luc Moquin, Alain Gratton, Emmanuel Darcq, Laura-Adela Harsan, Rafael Maldonado and Brigitte Kieffer, 2018, "Increased alcohol seeking in mice lacking Gpr88 involves dysfunctional mesocorticolimbic networks", Biological psychiatry, 84, (3), pp. 202-212
  • Aliza Ehrlich, Meriem Semache, Julie Bailly, Stefan Wojcik, Tanzil Arefin, Christine Colley, Christian Gouill, Florence Gross, Viktoriya Lukasheva, Mireille Hogue, Emmanuel Darcq, Laura-Adela Harsan, Michel Bouvier and Brigitte Kieffer, 2018, "Mapping GPR88-Venus illuminates a novel role for GPR88 in sensory processing", Brain Structure and Function, 223, pp. 1275-1296
  • Tanzil Arefin, Anna Mechling, Aura Meirsman, Thomas Bienert, Neele Huebner, Hsu-Lei Lee, Sami Ben Hamida, Aliza Ehrlich, Dan Roquet, Juergen Hennig, Dominik von Elverfeldt, Brigitte Kieffer and Laura-Adela Harsan, 2017, "Remodeling of Sensorimotor Brain Connectivity in Gpr88 deficient mice", Brain Connectivity, 7, (8), pp. 526-540
  • Anna Mechling, Tanzil Arefin, Hsu-Lei Lee, Thomas Bienert, Marco Reisert, Aliza Ehrlich, Claire Gaveriaux-Ruff, Maxime Parent, Pedro Rosa-Neto, Juergen Hennig, Dominik von Elverfeldt, Brigitte Kieffer and Laura-Adela Harsan, 2016, "Deletion of the mu opioid receptor gene in mice reshapes the reward–aversion connectome", PNAS, 113, (41), pp. 11603-11608
  • Tanzil Arefin, Choong Lee, Zifei Liang, Harikrishna Rallapalli, Youssef Wadghiri, Daniel Turnbull and Jiangyang ZhaNG, , "Towards reliable reconstruction of the mouse brain corticothalamic connectivity using diffusion MRI", Neuroimage, 273

Research Projects

Honors and Awards

  • Erasmus Mundus Fellowship, The European Union, October 2012 - September 2016
  • Erasmus Mundus Fellowship, The European Union, October 2010 - September 2012


Service to Penn State:

Service to External Organizations:




The Department of Biomedical Engineering administers the undergraduate major in biomedical engineering, and is a part of the university-wide Intercollege Graduate Degree Program, offering both M.S. and Ph.D. degrees in Bioengineering. Our work combines traditional engineering principles with medicine and technology for the betterment of human health and society. 

Department of Biomedical Engineering

122 Chemical and Biomedical Engineering Building

The Pennsylvania State University

University Park, PA 16802-4400

Phone: 814-863-6614