Photo of Scott Medina

Scott Medina

Assistant Professor of Biomedical Engineering


  • Biomedical Engineering

511 Chemical and Biomedical Engineering Building


Personal or Departmental Website

Research Areas:

Cell Signaling and Cancer; Nanomedicine and Drug Delivery; Tissue Engineering and Regenerative Medicine




  • BS, Civil Engineering, The Pennsylvania State University, 2006
  • MS, Biomedical Engineering, University of Michigan, 2008
  • Ph D, Biomedical Engineering, University of Michigan, 2012


Book, Chapters

  • Scott H Medina* and Joel P Schneider*, 2017, Chemical Ligations in the Design of Hydrogel Materials, Wiley Publishing


  • Y M Yu, W Song, T Ren, Y Shen, R Chowdhury, P Rajapaksha, T E Culp, L Samineni, L Chao, A Thokkadam, D Carson, Y Dai, A Mukthar, M Zhang, A Parshin, J N Sloand^, Scott H Medina, M Grzelakowski, D Bhattacharya, W A Phillip, E D Gomez, R J Hickey, Y Wei and M Kumar*, 2020, "Rapid Fabrication of Precise, High-Throughput Filters from Membrane Protein Nanosheets", Nature Materials
  • Andrew Simonson^, Atip Lawanprasert^, Tyler D Goralski, Kenneth C Keiler and Scott H Medina*, 2019, "Bioresponsive Peptide-Polysaccharide Nanogels – A Versatile Delivery System to Augment the Utility of Bioactive Cargo", Nanomedicine
  • Scott H. Medina*, Brian Bush, Maggaret Cam, Emily Sevcik, Frank W DelRio, Kaustav Nandy and Joel P Schneider*, 2019, "Identification of a Mechanogenetic Link between Substrate Stiffness and Chemotherapeutic Response in Breast Cancer", Biomaterials, 202
  • Anshika Kapur, Scott H Medina, Wentao Wang, Goutam Palui, Xin Ji, Joel P Schneider and Hedi Mattoussi*, 2018, "Enhanced Uptake of Luminescent Quantum Dots by Live Cells Mediated by a Membrane-Active Peptide", ACS Omega, 3, (12)
  • Matthew Aronson^, Andrew W Simonson^, Lindsey M Orchard, Manuel Llinás and Scott H. Medina*, 2018, "Lipopeptisomes: Anticancer Peptide-Assembled Particles for Fusolytic Oncotherapy", Acta Biomaterialia
  • Anshika Kapur, Scott H Medina, Wentao Wang, Goutam Palui, Joel P Schneider and Hedi Mattoussi*, 2018, "Intracellular Delivery of Gold Nanocolloids Promoted by a Chemically Conjugated Anticancer Peptide", ACS Omega, 3, (10)
  • Scott H Medina*, Megan S Michie, Stephen E Miller, Martin J Schnermann and Joel P Schneider*, 2017, "Fluorous Phase-Directed Peptide Assembly Affords Nano-Peptisomes Capable of Ultrasound-Triggered Cellular Delivery", Angewandte Chemie International Ed., 56, (38)
  • K Ishikawa, Scott H Medina, J P Schneider and A J Klar*, 2017, "Glycan Alteration Imparts Cellular Resistance to a Membrane-Lytic Anticancer Peptide.", Cell Chemical Biology, 24, (2)
  • Scott H Medina, Stephen E Miller, A I Keim, A P Gorka, M J Schnermann and J P Schneider*, 2016, "An Intrinsically Disordered Peptide Facilitates Non-Endosomal Cell Entry.", Angewandte Chemie International Ed., 55, (10), pp. 3369-72
  • Daniel Smith, Gabriel A Brat, Scott H Medina, Dedi Tong, Yong Huang, Johanna Grahammer, Georg J Furtmüller, Byoung C Oh, Katelyn J Nagy-Smith, Piote Walczak, Gerald Brandacher and Joel P Schneider*, 2016, "A Multiphase Transitioning Peptide Hydrogel for Suturing Ultrasmall Vessels.", Nature Nanotechnology, 11, (1), pp. 95-102
  • Scott H Medina and Joel P Schneider*, 2015, "Cancer Cell Surface Induced Peptide Folding Allows Intracellular Translocation of Drug.", Journal of Controlled Release, 209, pp. 317-26
  • Souvik Biswas, Scott H Medina, Joseph J Barchi and Jr*, 2015, "Synthesis and Cell-Selective Antitumor Properties of Amino Acid Conjugated Tumor-Associated Carbohydrate Antigen-Coated Gold Nanoparticles", Carbohydrate Research, 405, pp. 93-101
  • Christopher M Micklitsch, Scott Medina, Tuna Yucel, Katelyn J Nagy-Smith, Darrin J Pochan and Joel P Schneider*, 2015, "Influence of Hydrophobic Face Amino Acids on the Hydrogelation of ß-Hairpin Peptide Amphiphiles", Macromolecules, 48, (5)
  • Scott H Medina, Sandra Li, O M Howard, Michael Dunlap, Anna Trivett, Joel P Schneider and Joost J Oppenheim*, 2015, "Enhanced Immunostimulatory Effects of DNA-Encapsulated Peptide Hydrogels", Biomaterials, 53, pp. 545-53
  • Michael C Giano, Zuhaib Ibrahim, Scott H Medina, Karim A Sarhane, Joani M Christensen, Yuji Yamada, Gerald Brandacher and J P Schneider*, 2014, "Injectable Bioadhesive Hydrogels with Innate Antibacterial Properties", Nature Communications, 5, pp. 4095
  • Charity J Wallace, Scott H Medina and Mohamed E ElSayed*, 2014, "Effect of Rhamnolipids on Permeability Across Caco-2 Cell Monolayers.", Pharmaceutical Research, 31, (4), pp. 887-94
  • Scott H Medina, Gopinath Tiruchinapally, Maxim V Chevliakov, Yasemin Y Durmaz, Rachel N Stender, William D Ensminger, Donna S Shewach and Mohamed E Elsayed*, 2013, "Targeting Hepatic Cancer Cells with Pegylated Dendrimers Displaying N-Acetylgalactosamine and SP94 Peptide Ligands", Advanced Healthcare Materials, 2, (10), pp. 1337-50
  • Scott H Medina, Maxim V Chevliakov, Gopinath Tiruchinapally, Yasemin Y Durmaz, Sibu P Kuruvilla and Mohamed E Elsayed*, 2013, "Enzyme-Activated Nanoconjugates for Tunable Release of Doxorubicin in Hepatic Cancer Cells", Biomaterials, 34, (19), pp. 4655-66
  • Scott H Medina, Venkatesh Tekumalla, Maxim V Chevliakov, Donna S Shewach, William D Ensminger and Mohamed E El-Sayed*, 2011, "N-Acetylgalactosamine-Functionalized Dendrimers as Hepatic Cancer Cell-Targeted Carriers", Biomaterials, 32, (17), pp. 4118-29
  • Scott H Medina* and Mohamed E El-Sayed*, 2009, "Dendrimers as Carriers for Delivery of Chemotherapeutic Agents", Chemical Reviews, 109, (7), pp. 3141-57

Research Projects

  • May 2019 - April 2020, "Ultrasound-enabled strategies for synchronous imaging and therapy of venous blood clots," (Sponsor: College of Engineering).

Honors and Awards

  • NSF CAREER, National Science Foundation, May 2019 - April 2024
  • Outstanding Undergraduate Teaching Award, Penn State University, Dept. of Biomedical Engineering, May 2019 - May 2019
  • Early Career Investigator in Biological Chemistry, American Chemical Society, August 2019 - August 2019
  • Graduate Student - Best Presentation Award, Materials Research Society, November 2018 - November 2018
  • Invited Speaker, American Chemical Society, August 2017
  • Session Organizer, American Chemical Society, August 2017 - August 2017
  • Young Innovators of Cellular and Molecular Bioengineering, Cellular and Molecular Bioengineering - Biomedical Engineering Society, October 2020


Service to Penn State:

  • Participation in Recruitment and Retention Activities, Member, Graduate Recruitment, Graduate Recruitment Committee, Graduate Recruitment Committee, November 2016 - February 2017

Service to External Organizations:




The Department of Biomedical Engineering administers the undergraduate major in biomedical engineering, and is a part of the university-wide Intercollege Graduate Degree Program, offering both M.S. and Ph.D. degrees in Bioengineering. Our work combines traditional engineering principles with medicine and technology for the betterment of human health and society. 

Department of Biomedical Engineering

122 Chemical and Biomedical Engineering Building

The Pennsylvania State University

University Park, PA 16802-4400

Phone: 814-863-6614