Journal Articles

Lily Foley, Sonika Kohli, Shuchang Tian, Logan C Eisaman, Harshita Ganga, Gabrielle Hamner, Matthew R Aronson, Jordan E Bisanz and Scott H Medina*, 2026, "Core-shell commensal biocapsules for in situ gut microbiome engineering", Bioactive Materials, 65, pp. 796-808

Michael A Miller, Nicole Vo, Ivan Sokirniy, Justin Pritchard, Benjamin S Freedman and Scott H Medina*, 2026, "Ultrasound-Actuated Gene Editing in Human Kidney Organoids", Advanced Science, pp. e20402

Diptomit Biswas and Scott H Medina*, 2026, "Antimycobacterial Peptides: From Natural Product Discovery to AI Guided Design", Biochemistry, 65, (10), pp. 1628–1651

Fellype Diorgennes Cordeiro Gomes, Diptomit Biswas, Logan C Eisaman, Mary Cristina Ferreira Alves, Severino Alves Junior* and Scott H Medina*, 2026, "Antibacterial silver nanoparticle decorated gallium metal-organic frameworks for odontogenic infections", Scientific Reports, (16), pp. 16235

Inhye Kim, Keith Griffith, Dakota F Brockway, Nicole A Crowley and Scott Medina*, 2026, "Ultrasound actuated neuropeptide delivery across cerebrovascular interfaces using phase-change peptide nanoemulsions", Journal of Colloid and Interface Science, 705, pp. 139466

Hugh D Glossop, Gebremichal Gebretsadik, Sabiha Sultana, Diptomit Biswas, Nathan Schacht, Yue Yan, Hanna Y Gebremichael, Anthony D Baughn and Scott H Medina*, 2025, "Retro-inversion imparts antimycobacterial specificity to host defense peptides", Nature Communications, (17), pp. 469

Harminder Singh, Diptomit Biswas, Ji Ho Park, Mary E Landmesser, Dino J Ravnic and Scott H Medina*, 2025, "Non-invasive ultrasonic debridement of implant biofilms via hydrogen-sulfide releasing peptide nanoemulsions", Biomaterials, 321, pp. 123337

Inhye Kim and Scott H Medina*, 2025, "Ultrasonic disruption of circulating amyloid ß aggregates via phase-change peptide nanoemulsions", Biomaterials, 318, pp. 123146

Diptomit Biswas, Sara Benson, Aidan Matunis, Gebremichal Gebretsadik, Adam Wertz, Ben J StPierre, Nathan Schacht, Yue Yan, Hanna Y Gebremichael, Pak Kin Wong, Anthony D Baughn and Scott H Medina*, 2025, "Lead Informed Artificial Intelligence Mining of Antitubercular Host Defense Peptides", Biomacromolecules, 26, (5), pp. 3167-3179

Fellype Diorgennes Cordeiro Gomes, Mary C Ferreira Alves, Severino A Junior and Scott H Medina*, 2025, "Bactericidal Metal-Organic Gallium Frameworks – Synthesis to Application", Molecular Pharmaceutics, 22, (2), pp. 638-646

Atip Lawanprasert, Harminder Singh, Sopida Pimcharoen, Mariangely González Vargas, Arshiya Dewan, Girish S Kirimanjeswara and Scott H Medina*, 2024, "Heat Stable and Intrinsically Sterile Liquid Protein Formulations", Nature Communications, 15, pp. 10897

Inhye Kim, Jacob C Elliott, Atip Lawanprasert, Anthony M Koehle III, Grace M Wood, Rita Castro, Julianna C Simon and Scott Medina*, 2024, "Twinkling Peptide Nanoemulsions Enable Precision Ultrasound Detection of Atherosclerotic Plaques", Advanced Functional Materials, 35, (8), pp. 2415609

Harminder Singh, Atip Lawanprasert, Utkarsh Utkarsh, Sopida Pimcharoen, Arshiya Dewan, Dane Rahoi, Girish S Kirimanjeswara and Scott H Medina*, 2024, "Decoupling Fluorous Protein Coatings Yield Heat-Stable and Intrinsically Sterile Bioformulations.", ACS Applied Materials & Interfaces, 16, (30), pp. 38893–3890

Michael A Miller and Scott H Medina*, 2024, "Life at the interface: Engineering bio-nanomaterials through interfacial molecular self-assembly.", WIREs Nanomedicine and Nanobiotechnology, 16, (3), pp. e1966

Michael A Miller and Scott H Medina*, 2024, "Synthetic Colonic Mucus Enables the Development of Modular Microbiome Organoids.", Advanced Functional Materials, 34, (38), pp. 2402514

Atip Lawanprasert, Janna N Sloand, Mariangely González Vargas, Harminder Singh, Tomer Eldor, Michael A Miller, Sopida Pimcharoen, Jian Wang, Scott M Leighow, Justin R Pritchard, Nikolay V Dokholyan and Scott H Medina*, 2023, "Deciphering the mechanistic basis for perfluoroalkyl-protein interactions", ChemBioChem, 24, (13), pp. e202300159

Inhye Kim, Jacob C Elliott, Atip Lawanprasert, Grace M Wood, Julianna C Simon and Scott Medina*, 2023, "Real-time, in situ imaging of macrophages via phase-change peptide nanoemulsions", Small, 46, pp. e2301673

Nikki A Crowley* and Scott H Medina*, 2023, "Targeted and transient opening of the blood brain barrier in discrete neurocircuits and brain regions", Neuropsychopharmacology, 48, (1), pp. 253-254

Amy H Guadagno and Scott Medina*, 2023, "The manifold role of octapeptide repeats in prion protein assembly", Peptide Science, 115, (2), pp. e24303

Scott H Medina*, 2022, "Voices in Molecular Pharmaceutics: Meet Dr. Scott Medina, Manipulator of Biomaterial Properties for Precision Therapeutics", Molecular Pharmaceutics, 19, (12), pp. 4392

Atip Lawanprasert, Sopida Pimcharoen, Sarah E Sumner, Girish S Kirimanjeswara, Connor T Watson, Keefe B Manning and Scott H Medina*, 2022, "Heparin-Peptide Nanogranules for Thrombosis-Actuated Anticoagulation.", Small, 18, (46), pp. e2203751

Macy M Hale and Scott H Medina*, 2022, "Biomaterials-Enabled Antithrombotics: Recent Advances and Emerging Strategies", Molecular Pharmaceutics, 19, (12), pp. 4453-446

Atip Lawanprasert, Andrew W Simonson, Sarah E Sumner, McKayla J Nicol, Sopida Pimcharoen, Girish S Kirimanjeswara and Scott H Medina*, 2022, "Inhalable SARS-CoV-2 Mimetic Particles Induce Pleiotropic Antigen Presentation", Biomacromolecules, 23, (3), pp. 1158-1168.

Janna N Sloand, Tyler E Culp, Nichole M. Wonderling, Enrique D. Gomez and Scott H Medina*, 2021, "Mechanomorphogenic Films Formed via Interfacial Assembly of Fluorinated Amino Acids", Advanced Functional Materials, 31, (40), pp. 2104223

Janna N Sloand, Eric Rokni, Connor Watson, Michael A Miller, Keefe B and Scott H Medina*, 2021, "Ultrasound-Responsive Nanopeptisomes Enable Synchronous Spatial Imaging and Inhibition of Clot Growth in Deep Vein Thrombosis", Advanced Healthcare Materials, 10, (16), pp. e2100520

Andrew W Simonson, Todd M Ulstead, Atip Lawanprasert, Bailey Klein, Sarah Almarzooqi, E. Scott Halstead and Scott H Medina*, 2021, "Extracellular Matrix-Inspired Inhalable Aerogels for Rapid Clearance of Pulmonary Tuberculosis", Biomaterials, 273, pp. 120848

Atip Lawanprasert, Alda Chau, Janna N Sloand, Sean Hannifin and Scott Medina*, 2021, "Tuning the Interfacial Properties of Fluorous Colloids Toward Ultrasound Programmable Bioactivity", ACS Applied Materials & Interfaces, 13, (5), pp. 5989-5998

Matthew R Aronson, Scott Medina and Michael J Mitchell, 2021, "Peptide functionalized liposomes for receptor targeted cancer therapy", APL bioengineering, 5, (1), pp. 011501

Andrew W Simonson, Agustey S Mongia, Matthew R Aronson, John Alumasa, Dennis C Chan, Atip Lawanprasert, Michael D Howe, Adam Bolotsky, Tapas Mal, Christy George, Seyedehaida Ebrahimi, Anthony Baughn, Elizabeth Anne Proctor, Kenneth C Keiler and Scott Medina*, 2021, "Pathogen-specific antimicrobials engineered de novo through membrane-protein biomimicry", Nature Biomedical Engineering, 5, (5), pp. 467-480

Janna N Sloand, Michael A Miller and Scott H Medina*, 2020, "Fluorinated Peptide Biomaterials", Peptide Science, 113, (2), pp. e24184

Andrew W Simonson, Matthew R Aronson and Scott H Medina*, 2020, "Supramolecular Peptide Assemblies as Antimicrobial Scaffolds", Molecules, 25, (12), pp. 2751

Matthew R Aronson, Erika S Dahl, Jacob Halle, Andrew W Simonson, Rose A Gogal, Adam B Glick, Katherine M Aird and Scott H Medina*, 2020, "Re-engineering Antimicrobial Peptides into Oncolytics Targeting Drug-Resistant Ovarian Cancers", Cellular and Molecular Bioengineering, 13, (5), pp. 447-461

Janna N Sloand, Theodore T Nguyen, Scott A Zinck, Erik C Cook, Tawanda J Zimudzi, Scott A Schowalter, Adam B Glick, Julianna C Simon and Scott H Medina*, 2020, "Ultrasound-Guided Cytosolic Protein Delivery via Transient Fluorous Masks", ACS Nano, 14, (4), pp. 4061-4073

Atip Lawanprasert, Caitlin A Guinan, Erica A Langford, Carly E Hawkins, Janna N Sloand, Howard Fescemeyer, Matthew R Aronson, Jacob A Halle, Jim Marden* and Scott H Medina*, 2020, "Discovery of antitumor lectins from rainforest tree root transcriptomes", PLoS One, 15, (2), pp. e0229467

Y M Yu, W Song, T Ren, Y Shen, R Chowdhury, P Rajapaksha, T E Culp, L Samineni, L Chao, A Thokkadam, D Carson, Y Dai, A Mukthar, M Zhang, A Parshin, J N Sloand, Scott H Medina, M Grzelakowski, D Bhattacharya, W A Phillip, E D Gomez, R J Hickey, Y Wei and M Kumar*, 2020, "Rapid Fabrication of Precise, High-Throughput Filters from Membrane Protein Nanosheets", Nature Materials, 19, (3), pp. 347-354

Andrew Simonson, Atip Lawanprasert, Tyler D Goralski, Kenneth C Keiler and Scott H Medina*, 2019, "Bioresponsive Peptide-Polysaccharide Nanogels – A Versatile Delivery System to Augment the Utility of Bioactive Cargo", Nanomedicine, 17, pp. 391-400

Scott H. Medina*, Brian Bush, Maggaret Cam, Emily Sevcik, Frank W DelRio, Kaustav Nandy and Joel P Schneider*, 2019, "Identification of a Mechanogenetic Link between Substrate Stiffness and Chemotherapeutic Response in Breast Cancer", Biomaterials, 202, pp. 1-11

Anshika Kapur, Scott H Medina, Wentao Wang, Goutam Palui, Xin Ji, Joel P Schneider and Hedi Mattoussi*, 2018, "Enhanced Uptake of Luminescent Quantum Dots by Live Cells Mediated by a Membrane-Active Peptide", ACS Omega, 3, (12), pp. 17164-17172

Matthew Aronson, Andrew W Simonson, Lindsey M Orchard, Manuel Llinás and Scott H. Medina*, 2018, "Lipopeptisomes: Anticancer Peptide-Assembled Particles for Fusolytic Oncotherapy", Acta Biomaterialia, 80, pp. 269-277

Anshika Kapur, Scott H Medina, Wentao Wang, Goutam Palui, Joel P Schneider and Hedi Mattoussi*, 2018, "Intracellular Delivery of Gold Nanocolloids Promoted by a Chemically Conjugated Anticancer Peptide", ACS Omega, 3, (10), pp. 12754-12762

Scott H Medina*, Megan S Michie, Stephen E Miller, Martin J Schnermann and Joel P Schneider*, 2017, "Fluorous Phase-Directed Peptide Assembly Affords Nano-Peptisomes Capable of Ultrasound-Triggered Cellular Delivery", Angewandte Chemie International Ed., 56, (38), pp. 11404-11408

K Ishikawa, Scott H Medina, J P Schneider and A J Klar*, 2017, "Glycan Alteration Imparts Cellular Resistance to a Membrane-Lytic Anticancer Peptide", Cell Chemical Biology, 24, (2), pp. 149-158

Scott H Medina, Stephen E Miller, A I Keim, A P Gorka, M J Schnermann and J P Schneider*, 2016, "An Intrinsically Disordered Peptide Facilitates Non-Endosomal Cell Entry", Angewandte Chemie International Ed., 55, (10), pp. 3369-3372

Daniel Smith, Gabriel A Brat, Scott H Medina, Dedi Tong, Yong Huang, Johanna Grahammer, Georg J Furtmüller, Byoung C Oh, Katelyn J Nagy-Smith, Piote Walczak, Gerald Brandacher and Joel P Schneider*, 2016, "A Multiphase Transitioning Peptide Hydrogel for Suturing Ultrasmall Vessels", Nature Nanotechnology, 11, (1), pp. 95-102

Scott H Medina and Joel P Schneider*, 2015, "Cancer Cell Surface Induced Peptide Folding Allows Intracellular Translocation of Drug", Journal of Controlled Release, 209, pp. 317-326

Souvik Biswas, Scott H Medina, Joseph J Barchi and Jr*, 2015, "Synthesis and Cell-Selective Antitumor Properties of Amino Acid Conjugated Tumor-Associated Carbohydrate Antigen-Coated Gold Nanoparticles", Carbohydrate Research, 405, pp. 93-101

Scott H Medina, Sandra Li, O M Howard, Michael Dunlap, Anna Trivett, Joel P Schneider and Joost J Oppenheim*, 2015, "Enhanced Immunostimulatory Effects of DNA-Encapsulated Peptide Hydrogels", Biomaterials, 53, pp. 545-553

Christopher M Micklitsch, Scott Medina, Tuna Yucel, Katelyn J Nagy-Smith, Darrin J Pochan and Joel P Schneider, 2015, "Influence of hydrophobic face amino acids on the hydrogelation of beta-hairpin peptide amphiphiles", Macromolecules, 48, (5), pp. 1281-1288

Michael C Giano, Zuhaib Ibrahim, Scott H Medina, Karim A Sarhane, Joani M Christensen, Yuji Yamada, Gerald Brandacher and J P Schneider*, 2014, "Injectable Bioadhesive Hydrogels with Innate Antibacterial Properties", Nature Communications, 5, pp. 4095

Charity J Wallace, Scott H Medina and Mohamed E ElSayed*, 2014, "Effect of Rhamnolipids on Permeability Across Caco-2 Cell Monolayers", Pharmaceutical Research, 31, (4), pp. 887-894

Scott H Medina, Gopinath Tiruchinapally, Maxim V Chevliakov, Yasemin Y Durmaz, Rachel N Stender, William D Ensminger, Donna S Shewach and Mohamed E Elsayed*, 2013, "Targeting Hepatic Cancer Cells with Pegylated Dendrimers Displaying N-Acetylgalactosamine and SP94 Peptide Ligands", Advanced Healthcare Materials, 2, (10), pp. 1337-1350

Scott H Medina, Maxim V Chevliakov, Gopinath Tiruchinapally, Yasemin Y Durmaz, Sibu P Kuruvilla and Mohamed E Elsayed*, 2013, "Enzyme-Activated Nanoconjugates for Tunable Release of Doxorubicin in Hepatic Cancer Cells", Biomaterials, 34, (19), pp. 4655-4666

Scott H Medina, Venkatesh Tekumalla, Maxim V Chevliakov, Donna S Shewach, William D Ensminger and Mohamed E El-Sayed*, 2011, "N-Acetylgalactosamine-Functionalized Dendrimers as Hepatic Cancer Cell-Targeted Carriers", Biomaterials, 32, (17), pp. 4118-4129

Scott H Medina* and Mohamed E El-Sayed*, 2009, "Dendrimers as Carriers for Delivery of Chemotherapeutic Agents", Chemical Reviews, 109, (7), pp. 3141-3157

• May 2019 - April 2020, "Ultrasound-enabled strategies for synchronous imaging and therapy of venous blood clots," (Sponsor: The Pennsylvania State University - College of Engineering).

• Dorothy and J. Lloyd Huck Chair in Nano Bioengineering, Huck Institutes of the Life Sciences, June 2025 - May 2028

• William and Wendy Korb Early Career Professorship, PSU - College of Engineering, July 2023 - July 2026

• Penn State Excellence in Advising Award, Undergraduate Student Government’s Academic Assembly, April 2026

• Huck Leadership Fellow, Huck Institutes of the Life Sciences, June 2024 - June 2025

• DARPA Young Faculty Award, DARPA, August 2021 - July 2024

• NSF CAREER, National Science Foundation, May 2019 - April 2024

• Rising Star Award, Small (Journal), July 2023

• Rising Star Award, Cellular and Molecular Bioengineering Special Interest Group, Biomedical Engineering Society, January 2021

• Young Innovators of Cellular and Molecular Bioengineering, Cellular and Molecular Bioengineering - Biomedical Engineering Society, October 2020

• Young Innovator Award, Controlled Release Society, June 2020

• Early Career Investigator in Biological Chemistry, American Chemical Society, August 2019

• Outstanding Undergraduate Teaching Award, Penn State University, Dept. of Biomedical Engineering, May 2019

• Graduate Student - Best Presentation Award, Materials Research Society, November 2018

• Session Organizer, American Chemical Society, August 2017

Service to Penn State:

• Participation in Recruitment and Retention Activities, Member, Graduate Recruitment, Graduate Recruitment Committee, Graduate Recruitment Committee, November 2016 - February 2017

Service to External Organizations: