Photo of Scott Medina

Scott Medina

William and Wendy Korb Early Career Professor of Biomedical Engineering
Associate Professor of Biomedical Engineering


  • Biomedical Engineering
  • Center for Acoustics and Vibration

511 Chemical and Biomedical Engineering Building


Personal or Departmental Website

Research Areas:

Cell Signaling and Cancer; Nanomedicine and Drug Delivery; Tissue Engineering and Regenerative Medicine





Journal Articles

  • Atip Lawanprasert^, Janna N Sloand^, Mariangely González Vargas^, Harminder Singh^, Tomer Eldor, Michael A Miller^, Sopida Pimcharoen^, Jian Wang, Scott M Leighow, Justin R Pritchard, Nikolay V Dokholyan and Scott H Medina*, 2023, "Deciphering the mechanistic basis for perfluoroalkyl-protein interactions", ChemBioChem
  • Inhye Kim^, Jacob C Elliott, Atip Lawanprasert^, Grace M Wood, Julianna C Simon and Scott Medina*, 2023, "Real-time, in situ imaging of macrophages via phase-change peptide nanoemulsions", Small
  • Nikki A Crowley* and Scott H Medina*, 2023, "Targeted and transient opening of the blood brain barrier in discrete neurocircuits and brain regions", Neuropsychopharmacology, 48, pp. 2
  • Amy H Guadagno^ and Scott Medina*, 2023, "The manifold role of octapeptide repeats in prion protein assembly", Peptide Science
  • Scott H Medina*, 2022, "Voices in Molecular Pharmaceutics: Meet Dr. Scott Medina, Manipulator of Biomaterial Properties for Precision Therapeutics", Molecular Pharmaceutics, 19, (12), pp. 1
  • Atip Lawanprasert^, Sopida Pimcharoen^, Sarah E Sumner, Girish S Kirimanjeswara, Connor T Watson, Keefe B Manning and Scott H Medina*, 2022, "Heparin-Peptide Nanogranules for Thrombosis-Actuated Anticoagulation.", Small, 18, (46)
  • Macy M Hale and Scott H Medina*, 2022, "Biomaterials-Enabled Antithrombotics: Recent Advances and Emerging Strategies", Molecular Pharmaceutics, 19, (12), pp. 12
  • Atip Lawanprasert^, Andrew W Simonson^, Sarah E Sumner, McKayla J Nicol, Sopida Pimcharoen^, Girish S Kirimanjeswara and Scott H Medina*, 2022, "Inhalable SARS-CoV-2 Mimetic Particles Induce Pleiotropic Antigen Presentation", Biomacromolecules
  • Janna N Sloand^, Tyler E Culp, Nichole M. Wonderling, Enrique D. Gomez and Scott H Medina*, 2021, "Mechanomorphogenic Films Formed via Interfacial Assembly of Fluorinated Amino Acids", Advanced Functional Materials
  • Janna N Sloand^, Eric Rokni, Connor Watson, Michael A Miller^, Keefe B , C and Scott H Medina*, 2021, "Ultrasound-Responsive Nanopeptisomes Enable Synchronous Spatial Imaging and Inhibition of Clot Growth in Deep Vein Thrombosis", Advanced Healthcare Materials
  • Andrew W Simonson^, Todd M Ulstead, Atip Lawanprasert^, Bailey Klein^, Sarah Almarzooqi^, E. Scott Halstead and Scott H Medina*, 2021, "Extracellular Matrix-Inspired Inhalable Aerogels for Rapid Clearance of Pulmonary Tuberculosis", Biomaterials, 273
  • Atip Lawanprasert^, Alda Chau^, Janna N Sloand^, Sean Hannifin^ and Scott Medina*, 2021, "Tuning the Interfacial Properties of Fluorous Colloids Toward Ultrasound Programmable Bioactivity", ACS Applied Materials & Interfaces, 13, (5)
  • Matthew R Aronson^, Scott Medina and Michael J Mitchell, 2021, "Peptide functionalized liposomes for receptor targeted cancer therapy", APL bioengineering, 5, (1), pp. 011501
  • Andrew W Simonson^, Agustey S Mongia^, Matthew R Aronson^, John Alumasa, Dennis C Chan, Atip Lawanprasert^, Michael D Howe, Adam Bolotsky, Tapas Mal, Christy George, Seyedehaida Ebrahimi, Anthony Baughn, Elizabeth Anne Proctor, Kenneth C Keiler and Scott Medina*, 2021, "Pathogen-specific antimicrobials engineered de novo through membrane-protein biomimicry", Nature Biomedical Engineering, 5, pp. 467-480
  • Janna N Sloand^, Michael A Miller^ and Scott H Medina*, 2020, "Fluorinated Peptide Biomaterials", Peptide Science, pp. e24184
  • Andrew W Simonson^, Matthew R Aronson^ and Scott H Medina*, 2020, "Supramolecular Peptide Assemblies as Antimicrobial Scaffolds", Molecules, 25, (12), pp. 2751
  • Matthew R Aronson^, Erika S Dahl, Jacob Halle^, Andrew W Simonson^, Rose A Gogal, Adam B Glick, Katherine M Aird and Scott H Medina*, 2020, "Re-engineering Antimicrobial Peptides into Oncolytics Targeting Drug-Resistant Ovarian Cancers", Cellular and Molecular Bioengineering, pp. 1-15
  • Janna N Sloand^, Theodore T Nguyen, Scott A Zinck, Erik C Cook, Tawanda J Zimudzi, Scott A Schowalter, Adam B Glick, Julianna C Simon and Scott H Medina*, 2020, "Ultrasound-Guided Cytosolic Protein Delivery via Transient Fluorous Masks", ACS Nano, 14, (4), pp. 4061-4073
  • Atip Lawanprasert^, Caitlin A Guinan, Erica A Langford, Carly E Hawkins, Janna N Sloand^, Howard Fescemeyer, Matthew R Aronson^, Jacob A Halle^, Jim Marden* and Scott H Medina*, 2020, "Discovery of antitumor lectins from rainforest tree root transcriptomes", PLoS One, 15, (2), pp. e0229467
  • Y M Yu, W Song, T Ren, Y Shen, R Chowdhury, P Rajapaksha, T E Culp, L Samineni, L Chao, A Thokkadam, D Carson, Y Dai, A Mukthar, M Zhang, A Parshin, J N Sloand^, Scott H Medina, M Grzelakowski, D Bhattacharya, W A Phillip, E D Gomez, R J Hickey, Y Wei and M Kumar*, 2020, "Rapid Fabrication of Precise, High-Throughput Filters from Membrane Protein Nanosheets", Nature Materials, pp. 1-8
  • Andrew Simonson^, Atip Lawanprasert^, Tyler D Goralski, Kenneth C Keiler and Scott H Medina*, 2019, "Bioresponsive Peptide-Polysaccharide Nanogels – A Versatile Delivery System to Augment the Utility of Bioactive Cargo", Nanomedicine
  • Scott H. Medina*, Brian Bush, Maggaret Cam, Emily Sevcik, Frank W DelRio, Kaustav Nandy and Joel P Schneider*, 2019, "Identification of a Mechanogenetic Link between Substrate Stiffness and Chemotherapeutic Response in Breast Cancer", Biomaterials, 202
  • Anshika Kapur, Scott H Medina, Wentao Wang, Goutam Palui, Xin Ji, Joel P Schneider and Hedi Mattoussi*, 2018, "Enhanced Uptake of Luminescent Quantum Dots by Live Cells Mediated by a Membrane-Active Peptide", ACS Omega, 3, (12)
  • Matthew Aronson^, Andrew W Simonson^, Lindsey M Orchard, Manuel Llinás and Scott H. Medina*, 2018, "Lipopeptisomes: Anticancer Peptide-Assembled Particles for Fusolytic Oncotherapy", Acta Biomaterialia
  • Anshika Kapur, Scott H Medina, Wentao Wang, Goutam Palui, Joel P Schneider and Hedi Mattoussi*, 2018, "Intracellular Delivery of Gold Nanocolloids Promoted by a Chemically Conjugated Anticancer Peptide", ACS Omega, 3, (10)
  • Scott H Medina*, Megan S Michie, Stephen E Miller, Martin J Schnermann and Joel P Schneider*, 2017, "Fluorous Phase-Directed Peptide Assembly Affords Nano-Peptisomes Capable of Ultrasound-Triggered Cellular Delivery", Angewandte Chemie International Ed., 56, (38), pp. 4
  • K Ishikawa, Scott H Medina, J P Schneider and A J Klar*, 2017, "Glycan Alteration Imparts Cellular Resistance to a Membrane-Lytic Anticancer Peptide", Cell Chemical Biology, 24, (2)
  • Scott H Medina, Stephen E Miller, A I Keim, A P Gorka, M J Schnermann and J P Schneider*, 2016, "An Intrinsically Disordered Peptide Facilitates Non-Endosomal Cell Entry", Angewandte Chemie International Ed., 55, (10), pp. 3369-72
  • Daniel Smith, Gabriel A Brat, Scott H Medina, Dedi Tong, Yong Huang, Johanna Grahammer, Georg J Furtmüller, Byoung C Oh, Katelyn J Nagy-Smith, Piote Walczak, Gerald Brandacher and Joel P Schneider*, 2016, "A Multiphase Transitioning Peptide Hydrogel for Suturing Ultrasmall Vessels", Nature Nanotechnology, 11, (1), pp. 95-102
  • Scott H Medina and Joel P Schneider*, 2015, "Cancer Cell Surface Induced Peptide Folding Allows Intracellular Translocation of Drug", Journal of Controlled Release, 209, pp. 317-26
  • Souvik Biswas, Scott H Medina, Joseph J Barchi and Jr*, 2015, "Synthesis and Cell-Selective Antitumor Properties of Amino Acid Conjugated Tumor-Associated Carbohydrate Antigen-Coated Gold Nanoparticles", Carbohydrate Research, 405, pp. 93-101
  • Christopher M Micklitsch, Scott Medina, Tuna Yucel, Katelyn J Nagy-Smith, Darrin J Pochan and Joel P Schneider*, 2015, "Influence of Hydrophobic Face Amino Acids on the Hydrogelation of ß-Hairpin Peptide Amphiphiles", Macromolecules, 48, (5)
  • Scott H Medina, Sandra Li, O M Howard, Michael Dunlap, Anna Trivett, Joel P Schneider and Joost J Oppenheim*, 2015, "Enhanced Immunostimulatory Effects of DNA-Encapsulated Peptide Hydrogels", Biomaterials, 53, pp. 545-53
  • Christopher M Micklitsch, Scott Medina, Tuna Yucel, Katelyn J Nagy-Smith, Darrin J Pochan and Joel P Schneider, 2015, "Influence of hydrophobic face amino acids on the hydrogelation of beta-hairpin peptide amphiphiles", Macromolecules, 48, (5), pp. 1281--1288
  • Michael C Giano, Zuhaib Ibrahim, Scott H Medina, Karim A Sarhane, Joani M Christensen, Yuji Yamada, Gerald Brandacher and J P Schneider*, 2014, "Injectable Bioadhesive Hydrogels with Innate Antibacterial Properties", Nature Communications, 5, pp. 4095
  • Charity J Wallace, Scott H Medina and Mohamed E ElSayed*, 2014, "Effect of Rhamnolipids on Permeability Across Caco-2 Cell Monolayers", Pharmaceutical Research, 31, (4), pp. 887-94
  • Scott H Medina, Gopinath Tiruchinapally, Maxim V Chevliakov, Yasemin Y Durmaz, Rachel N Stender, William D Ensminger, Donna S Shewach and Mohamed E Elsayed*, 2013, "Targeting Hepatic Cancer Cells with Pegylated Dendrimers Displaying N-Acetylgalactosamine and SP94 Peptide Ligands", Advanced Healthcare Materials, 2, (10), pp. 1337-50
  • Scott H Medina, Maxim V Chevliakov, Gopinath Tiruchinapally, Yasemin Y Durmaz, Sibu P Kuruvilla and Mohamed E Elsayed*, 2013, "Enzyme-Activated Nanoconjugates for Tunable Release of Doxorubicin in Hepatic Cancer Cells", Biomaterials, 34, (19), pp. 4655-66
  • Scott H Medina, Venkatesh Tekumalla, Maxim V Chevliakov, Donna S Shewach, William D Ensminger and Mohamed E El-Sayed*, 2011, "N-Acetylgalactosamine-Functionalized Dendrimers as Hepatic Cancer Cell-Targeted Carriers", Biomaterials, 32, (17), pp. 4118-29
  • Scott H Medina* and Mohamed E El-Sayed*, 2009, "Dendrimers as Carriers for Delivery of Chemotherapeutic Agents", Chemical Reviews, 109, (7), pp. 3141-57

Conference Proceedings

  • Andrew Simonson, Agustey Mongia, Matthew Aronson, Tyler Goralski, Kenneth C Keiler and Scott Medina, 2019, "Tryptophan-zippered'Trojan horse'peptides with anti-tuberculosis specific activity", 258
  • Janna Sloand, Erik Cook, Tawanda Zimudzi, Scott Zinck, Julianna Simon, Scott A Showalter and Scott Medina, 2019, "Ultrasound-sensitive fluorous nanoemulsions enable image-guided cytosolic protein delivery", 258
  • Anshika Kapur, Wentao Wang, Juan Diaz Hernandez, Scott Medina, Joel P Schneider and Hedi Mattoussi, 2018, "Anti-microbial peptide facilitated cytosolic delivery of metallic gold nanomaterials", 10507, pp. 105070R
  • Scott Medina, 2017, "Evolution of stimuli-responsive peptide nanocarriers from hydrogel materials", 254
  • Anshika Kapur, Malak Safi, Tatiana Domitrovic, Scott Medina, Goutam Palui, John E Johnson, Joel Schneider and Hedi Mattoussi, 2017, "Peptide mediated intracellular delivery of semiconductor quantum dots", 10078, pp. 100780S
  • Hedi Mattoussi, Anshika Kapur, Goutam Palui, Wentao Wang, Scott Medina and Joel Schneider, 2016, "Cytosolic internalization of luminescent quantum dots", 252
  • Scott Medina, Stephen Miller and Joel Schneider, 2016, "Evolution of cancer-targeting peptides from hydrogel materials", 251
  • C Sinthuvanich, Scott Medina and John Schneider, 2013, "Cancer-cell Localization and Anticancer Activity of the SVS-1 Peptide", 100, (3), pp. 255--255


  • Scott Medina, 2012, "Development of Targeted, Enzyme-Activated, Dendrimer-Drug Nano-Conjugates for Hepatic Cancer Therapy."

Research Projects

  • May 2019 - April 2020, "Ultrasound-enabled strategies for synchronous imaging and therapy of venous blood clots," (Sponsor: The Pennsylvania State University - College of Engineering).

Honors and Awards

  • William and Wendy Korb Early Career Professorship, PSU - College of Engineering, July 2023 - July 2026
  • NSF CAREER, National Science Foundation, May 2019 - April 2024
  • DARPA Young Faculty Award, DARPA, August 2021 - July 2024
  • Rising Star Award, Small (Journal), July 2023 - July 2023
  • Rising Star Award, Cellular and Molecular Bioengineering Special Interest Group, Biomedical Engineering Society, January 2021
  • Young Innovators of Cellular and Molecular Bioengineering, Cellular and Molecular Bioengineering - Biomedical Engineering Society, October 2020
  • Young Innovator Award, Controlled Release Society, June 2020
  • Early Career Investigator in Biological Chemistry, American Chemical Society, August 2019
  • Outstanding Undergraduate Teaching Award, Penn State University, Dept. of Biomedical Engineering, May 2019
  • Graduate Student - Best Presentation Award, Materials Research Society, November 2018
  • Invited Speaker, American Chemical Society, August 2017
  • Session Organizer, American Chemical Society, August 2017


Service to Penn State:

  • Participation in Recruitment and Retention Activities, Member, Graduate Recruitment, Graduate Recruitment Committee, Graduate Recruitment Committee, November 2016 - February 2017

Service to External Organizations:




The Department of Biomedical Engineering administers the bachelor of science, master of science, and doctorate degree programs in biomedical engineering. Our work combines traditional engineering principles with medicine and technology for the betterment of human health and society. 

Department of Biomedical Engineering

122 Chemical and Biomedical Engineering Building

The Pennsylvania State University

University Park, PA 16802-4400

Phone: 814-863-6614