Photo of Patrick Drew

Patrick Drew

Associate Professor

Affiliation(s):

  • Engineering Science and Mechanics
  • Biomedical Engineering

W317 Millennium Science Complex

pjd17@psu.edu

814-863-1473

Personal or Departmental Website

Research Areas:

Brain Science and Neural Engineering

Interest Areas:

Neuroscience, neurovascular coupling.

 
 

 

Education

  • BS, Biology, California Institute of Technology, 1999
  • Ph D, Neuroscience, Brandeis University, 2004

Publications

Book, Chapters

  • A Shih, P Drew and D Kleinfeld, 2014, Imaging vasodynamics in the awake mouse brain with two-photon microscopy, Springer Science + Business Media, NY, pp. 55-73
  • J Driscoll, A Shih, Patrick Drew, I Valmianski, G Cauwenberg ands, D , 2011, Two-photon imaging of blood flow in rat cortex., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 927-938

Journal Articles

  • Patrick Drew, A T Winder and Qiming Zhang, 2019, "Twitches, Blinks, and Fidgets: Important Generators of Ongoing Neural Activity.", The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 25, (4), pp. 298-313
  • Patrick Drew, 2019, "Vascular and neural basis of the BOLD signal.", Current opinion in neurobiology, 58, pp. 61-69
  • J N Norwood, Q Zhang, D Card, A Craine, Timothy M Ryan and Patrick Drew, 2019, "Anatomical basis and physiological role of cerebrospinal fluid transport through the murine cribriform plate.", eLife
  • Matthew Adams, A T Winder, P Blinder and Patrick Drew, 2018, "The pial vasculature of the mouse develops according to a sensory-independent program.", Scientific reports, 8, (1), pp. 9860
  • Paddy Ssentongo, Anna E. Robuccio, Godfrey Thuku, Derek G Sim, Ali Nabi, Fatemeh Bahari, Balaji Shanmugasundaram, Myles W. Billard, Andrew Geronimo, Kurt W. Short, Patrick Drew, Jennifer Baccon, Steven L. Weinstein, Frank G. Gilliam, Jose A. Stoute, Vernon M Chinchilli, Andrew F Read, Bruce Gluckman and Steven Schiff, 2017, "A Murine Model to Study Epilepsy and SUDEP Induced by Malaria Infection", SCIENTIFIC REPORTS, 7
  • Yu-Rong Gao, Yuncong Ma, Qingguang Zhang, Aaron T. Winder, Zhifeng Liang, Lilith Antinori, Patrick Drew and Nanyin Zhang, 2017, "Time to wake up: Studying neurovascular coupling and brain-wide circuit function in the un-anesthetized animal", NEUROIMAGE, 153, pp. 382-398
  • Aaron T. Winder, Christina Echagarruga, Qingguang Zhang and Patrick Drew, 2017, "Weak correlations between hemodynamic signals and ongoing neural activity during the resting state", Nature Neuroscience, 20, (12), pp. 1761-1769
  • Y R Gao and Patrick Drew, 2016, "Effects of Voluntary Locomotion and Calcitonin Gene-Related Peptide on the Dynamics of Single Dural Vessels in Awake Mice.", The Journal of neuroscience : the official journal of the Society for Neuroscience, 36, (8), pp. 2503-16
  • B X Huo, S E Greene and Patrick Drew, 2015, "Venous cerebral blood volume increase during voluntary locomotion reflects cardiovascular changes.", NeuroImage, 118, pp. 301-12
  • Y R Gao, S E Greene and Patrick Drew, 2015, "Mechanical restriction of intracortical vessel dilation by brain tissue sculpts the hemodynamic response.", NeuroImage, 115, pp. 162-76
  • M J Shirey, J B Smith, S E Greene, B X Huo and Patrick Drew, 2015, "Brief anesthesia, but not voluntary locomotion, significantly alters cortical temperature.", Journal of neurophysiology, 114, (1), pp. 309-22
  • A Y Shih, C Rühlmann, P Blinder, A Devor, Patrick Drew, B Friedman, P M Knutsen, P D Lyden, C Matéo, L Mellander, N Nishimura, C B Schaffer, P S Tsai and D Kleinfeld, 2015, "Robust and fragile aspects of cortical blood flow in relation to the underlying angioarchitecture.", Microcirculation (New York, N.Y. : 1994), 22, (3), pp. 204-18
  • Bing-Xing Huo, Yu-Rong Gao and Patrick Drew, 2015, "Quantitative separation of arterial and venous cerebral blood volume increases during voluntary locomotion.", NeuroImage, 105, pp. 369-79
  • A Letourneur, V Chen, G Waterman and Patrick Drew, 2014, "A method for longitudinal, transcranial imaging of blood flow and remodeling of the cerebral vasculature in postnatal mice", Physiological Reports, 2, (12), pp. 10
  • Yu-Rong Gao and Patrick Drew, 2014, "Determination of vessel cross-sectional area by thresholding in Radon space.", Journal of Cerebral Blood Flow and Metabolism, 34, pp. 1180-1187
  • Bing-Xing Huo, Jared B Smith and Patrick Drew, 2014, "Neurovascular Coupling and Decoupling in the Cortex during Voluntary Locomotion.", Journal of Neuroscience, 34, (33), pp. 10975-81
  • Jonathan D Driscoll, Andy Y Shih, Patrick Drew, Gert Cauwenberghs and David Kleinfeld, 2013, "Two-photon imaging of blood flow in the rat cortex.", Cold Spring Harb Protoc, 8, pp. 759-67
  • Andy Y Shih, Celine Mateo, Patrick Drew, Philbert S Tsai and David Kleinfeld, 2012, "A polished and reinforced thinned-skull window for long-term imaging of the mouse brain.", JoVE, 61
  • A Y Shih, J D Driscoll, P J Drew, N Nishimura, C B Schaffer and D Kleinfeld, 2012, "Two-photon microscopy as a tool to study blood flow and neurovascular coupling in the rodent brain", J Cereb Blood Flow Metab, 32, (7), pp. 277-309
  • David Kleinfeld, Pablo Blinder, Patrick Drew, Jonathan D Driscoll, Arnaud Muller, Philbert S Tsai and Andy Y Shih, 2011, "A guide to delineate the logic of neurovascular signaling in the brain.", Frontiers in Neuroenergetics, 3, (1)
  • Patrick Drew, Andy Y Shih and David Kleinfeld, 2011, "Fluctuating and sensory-induced vasodynamics in rodent cortex extend arteriole capacity.", Proceedings of the National Acadamy of Sciences, 108, (20), pp. 8473-8478
  • Patrick Drew, Andy Y Shih, Jonathan D Driscoll, Per Magne Knutsen, Pablo Blinder, Dimitrios Davalos, Katerina Akassoglou, Philbert S Tsai and David Kleinfeld, 2010, "Chronic optical access through a polished and reinforced thinned skull.", Nature Methods, 7, (12), pp. 981-984
  • Patrick Drew, Pablo Blinder, Gert Cauwenberghs, Andy Y Shih and David Kleinfeld, 2010, "Rapid determination of particle velocity from space-time images using the Radon transform.", Journal of Computational Neuroscience, 29, (1-2), pp. 5-11
  • Andy Y Shih, Beth Friedman, Patrick Drew, Philbert S Tsai, Patrick D Lyden and David Kleinfeld, 2009, "Active dilation of penetrating arterioles restores red blood cell flux to penumbral neocortex after focal stroke.", Journal of Cerebral Blood Flow and Metabolism, 29, (4), pp. 738-51
  • Philbert S Tsai, John P Kaufhold, Pablo Blinder, Beth Friedman, Patrick Drew, Harvey J Karten, Patrick D Lyden and David Kleinfeld, 2009, "Correlations of neuronal and microvascular densities in murine cortex revealed by direct counting and colocalization of nuclei and vessels.", Journal of Neuroscience, 29, (46), pp. 14553-70
  • Lu Li, Kevin J Bender, Patrick Drew, Shantanu P Jadhav, Emily Sylwestrak and Daniel E Feldman, 2009, "Endocannabinoid signaling is required for development and critical period plasticity of the whisker map in somatosensory cortex.", Neuron, 64, (4)
  • Patrick Drew and Daniel E Feldman, 2009, "Intrinsic signal imaging of deprivation-induced contraction of whisker representations in rat somatosensory cortex.", Cerebral Cortex, 19, (2), pp. 331-48
  • Patrick Drew, Jeff H Duyn, Eugene Golanov and David Kleinfeld, 2008, "Finding coherence in spontaneous oscillations.", Nature Neuroscience, 11, (9)
  • Jason Wolfe, Dan N Hill, Sohrab Pahlavan, Patrick Drew, David Kleinfeld and Daniel E Feldman, 2008, "Texture coding in the rat whisker system: slip-stick versus differential resonance.", PLOS Biology, 6, (8), pp. e215
  • Patrick Drew and Daniel E Feldman, 2007, "Representation of moving wavefronts of whisker deflection in rat somatosensory cortex.", Journal of Neurophysiology, 98, (3), pp. 1566-80
  • P J Drew and L F Abbott, 2006, "Extending the effects of spike-timing-dependent plasticity to behavioral timescales", Proceedings of the National Acadamy of Sciences, 103, (23), pp. 8876-81
  • P J Drew and L F Abbott, 2006, "Models and properties of power-law adaptation in neural systems", Journal of Neurophysiology, 96, (2), pp. 826-81
  • S Fusi, P J Drew and LF Abbott, 2005, "Cascade models of synaptically stored memories", Neuron, 45, (2), pp. 2697-706
  • P J Drew and L F Abbott, 2003, "Model of song selectivity and sequence generation in area HVc of the songbird", Joournal of Neurophysiology, 89, (5), pp. 2697-2706
  • Patrick Drew, R Sayres, K Watanabe and S Shimojo, 2001, "Pupillary response to chromatic flicker", Experimental Brain Research, (136)

Conference Proceedings

  • Kurt W. Short, Ephraim W. Church, Akshal S. Patel, Kevin M. Cockroft and Patrick Drew, 2016, "Absence of Cortical Microvessel Spasm During Large Vessel Spasm Following Experimental Subarachnoid Hemorrhage", STROKE, 47

Abstracts

  • Qingguang Zhang, Kyle Gheres and Patrick Drew, 2017, "Noradrenergic modulation of neurovascular coupling in awake behaving mice"
  • Qingguang Zhang, Kyle Gheres and Patrick Drew, 2017, "Neuronal and non-neuronal factors mediate behavioral-state dependent development of functional hyperemia in the somatosensory cortex of juvenile mice"
  • Priankshesh Patki, Bruce Gluckman, Francesco Costanzo and Patrick Drew, 2017, "Mixture theory based analysis of the glymphatic system"

Research Projects

Honors and Awards

Service

Service to Penn State:

Service to External Organizations:

 


 

About

The Department of Biomedical Engineering administers the undergraduate major in biomedical engineering, and is a part of the university-wide Intercollege Graduate Degree Program, offering both M.S. and Ph.D. degrees in Bioengineering. Our work combines traditional engineering principles with medicine and technology for the betterment of human health and society. 

Department of Biomedical Engineering

122 Chemical and Biomedical Engineering Building

The Pennsylvania State University

University Park, PA 16802-4400

Phone: 814-863-6614