Photo of Yong Wang

Yong Wang

Professor of Biomedical Engineering


  • Biomedical Engineering

526 Chemical and Biomedical Engineering Building


Personal or Departmental Website

Research Areas:

Biomaterials and Drug Delivery; Nanomedicine and Drug Delivery

Interest Areas:

Biomaterials, Drug delivery, Tissue regeneration, Biomimetic engineering, Nucleic acid aptamers.




  • BS, Environmental Chemistry, Jilin University, 1995
  • MS, Chemical Engineering, Chinese Academy of Sciences, 1998
  • Ph D, Biomedical Engineering, Duke University, 2004


Journal Articles

  • James Coyne, Nan Zhao, Anuoluwapo Olubode, Mridula Menon and Yong Wang, 2020, "Development of hydrogel-like biomaterials via nanoparticle assembly and solid-hydrogel transformation", Journal of Controlled Release
  • Nan Zhao, James Coyne, Lidya Abune, Peng Shi, Xiaojun Lance Lian, Ge Zhang and Yong Wang, 2020, "Exogenous signaling molecules released from aptamer-functionalized hydrogels promote the survival of mesenchymal stem cell spheroids", ACS Applied Materials \& Interfaces
  • Peng Shi, Xuelin Wang, Brandon Davis, James Coyne, Cheng Dong, Joshua Reynolds and Yong Wang, 2020, "In situ synthesis of aptamer-based polyvalent antibody mimic on the cell surface for enhanced immune-cancer cell interactions", Angewandte Chemie International Edition
  • Chao Li, Ming Xu, James Coyne, Wei-Bei Wang, Micha L Davila, Yong Wang and Na Xiong, 2020, "Psoriasis-associated impairment of CCL27/CCR10-derived regulation leads to IL-17A/IL-22--producing skin T-cell overactivation", Journal of Allergy and Clinical Immunology
  • Peng Shi and Yong Wang, 2020, "Synthetic DNA for cell surface engineering", Angewandte Chemie International Edition
  • Nan Zhao, James Coyne, Ming Xu, Xiaolong Zhang, Akiho Suzuki, Peng Shi, Jinping Lai, Guo-Hua Fong, Na Xiong and Yong Wang, 2019, "Assembly of Bifunctional Aptamer-Fibrinogen Macromer for VEGF Delivery and Skin Wound Healing", Chemistry of Materials
  • Jinping Lai, Lidya Abune, Nan Zhao and Yong Wang, 2019, "Programmed Degradation of Hydrogels with a Double-Locked Domain", Angewandte Chemie International Edition
  • Otto Juhl, IV, Nan Zhao, Anna-Blessing Merife, David Cohen, Michael Friedman, Yue Zhang, Zvi Schwartz, Yong Wang and Henry J Donahue, 2019, "Aptamer-Functionalized Fibrin Hydrogel Improves Vascular Endothelial Growth Factor Release Kinetics and Enhances Angiogenesis and Osteogenesis in Critically Sized Cranial Defects", ACS Biomaterials Science \& Engineering, 5, (11), pp. 6152--6160
  • Peng Shi, Nan Zhao, James Coyne and Yong Wang, 2019, "DNA-templated synthesis of biomimetic cell wall for nanoencapsulation and protection of mammalian cells", Nature Communications, 10, pp. 2223
  • Nan Zhao, Akiho Suzuki, Xiaolong Zhang, Peng Shi, Lidya Abune, James Coyne, Huizhen Jia, Na Xiong, Ge Zhang and Yong Wang, 2019, "Dual Aptamer-Functionalized in Situ Injectable Fibrin Hydrogel for Promotion of Angiogenesis via Codelivery of Vascular Endothelial Growth Factor and Platelet-Derived Growth Factor-BB", ACS Applied Materials \& Interfaces
  • Lidya Abune, Nan Zhao, Jinping Lai, Benjamin Peterson, Spencer Szczesny and Yong Wang, 2019, "Macroporous Hydrogels for Stable Sequestration and Sustained Release of Vascular Endothelial Growth Factor and Basic Fibroblast Growth Factor Using Nucleic Acid Aptamers", ACS Biomaterials Science \& Engineering, 5, (5), pp. 2382--2390
  • Haoyang Chen, Sumit Agrawal, Ajay Dangi, Christopher Wible, Mohamed Osman, Lidya Abune, Huizhen Jia, Randall Rossi, Yong Wang, Kothapalli and Sri-Rajasekhar ., 2019, "Optical-Resolution Photoacoustic Microscopy Using Transparent Ultrasound Transducer", Sensors, 19, pp. 5470
  • Peng Shi, Nan Zhao, Jinping Lai, James Coyne and Erin Gaddes, 2018, "Polyvalent display of biomolecules on the live cells", Angewandte Chemie Interntional Edition
  • Yong Wang, 2018, "Programmable Hydrogels", Biomaterials, 178, pp. 663-680
  • Pinliang Jiang, Shihui Li, jinping Lai, Hong Zheng, Changjian lin, Peng Shi and Yong Wang, 2017, "Nanoparticle-Programmed Surface for Drug Release and Cell Regulation via Reversible Hybridization Reaction", ACS Appl. Mater. Interfaces, 9(5), pp. 4467-4474
  • Jinping LAI, Pinliang Jiang, Erin Gaddes, Nan Zhao, Lidya Abune and Yong Wang, 2017, "Aptamer-Functionalized Hydrogel for Self-Programmed Protein Release via Sequential Photoreaction and Hybridization", Chemistry of Materials, 29, pp. 5850-5857
  • Nan Zhao, Mark Battig, Ming Xu, Xiuli Wang, Na Xiong and Yong Wang, 2017, "Development of a Dual-Functional Hydrogel Using RGD and Anti-VEGF Aptamer", Macromolecular Bioscience, 17, pp. 1700201
  • Jinping Lai, Shihui Li, Xuechen Shi, James Coyne, Nan Zhao, Fengping Dong, Yingwei Mao and Yong Wang, 2017, "Displacement and Hybridization Reactions for Controlled Protein Release from Synthetic Hydrogel", Chemical Science, 8, pp. 7306-7311
  • James Coyne, Brandon Davis, David Kauffman, Nan Zhao and Yong Wang, 2017, "Polymer microneedle mediated local aptamer delivery for blocking the function of VEGF", ACS Biomaterials Science & Engineering, 3(12), pp. 3395-3403
  • N Chen, X Shi and Yong Wang, 2016, "Molecularly Regulated Reversible DNA Polymerization.", Angewandte Chemie, 55, (23), pp. 6657-6661
  • Wafa Aresh, Ying Liu, Jessica Sine, Anu Puri, Yike Huang, Yong Wang and Mu-Ping Nieh, 2016, "The Morphology of Self-Assembled Lipid-Based Nanoparticles Affects Their Uptake by Cancer Cells", J. Biomed Nanotechnol, 12, pp. 1852-1863
  • Xiaolong Zhang, Mark Battig, Niancao Chen, Erin Gaddes, Katelyn Duncan and Yong Wang, 2016, "Chimeric oligonucleotide-protein hydrogels as an extracellular matrix mimic carrying cells and growth factors", Biomacromolecules, 17, (3), pp. 778-787
  • Erin Gaddes, Debra Lee, Gregory Gydush, Yong Wang, Cheng D andng, , 2015, "Regulation of fibrin-mediated tumor cell adhesion to the endothelium using anti-thrombin aptamer", Experimental Cell Research, 339, (2), pp. 417-426
  • S Li, E R Gaddes, N Chen and Yong Wang, 2015, "Molecular encryption and reconfiguration for remodeling of dynamic hydrogels.", Angewandte Chemie International Edition, 54, (20), pp. 5957-61
  • E R Gaddes, G Gydush, S Li, N Chen, Cheng Dong and Yong Wang, 2015, "Aptamer-based polyvalent ligands for regulated cell attachment on the hydrogel surface.", Biomacromolecules, 16, (4), pp. 1382-1389
  • Tuba Ozdemir, Erin Gaddes, Yong Wang and Cheng Dong, 2015, "Perspectives: Interplay between melanoma regulated fibrin and receptor mediated adhesion under shear flow", Cellular and Molecular Bioengineering, 8, (1), pp. 86-95
  • Shihui Li, Niancao Chen, Erin Gaddes, xiaolong zhang, Cheng Dong and Yong Wang, 2015, "A Drosera-bioinspired hydrogel for catching and killing target cells", Scientific Reports, 5, pp. 14297
  • E Richards, S Li, N Chen, M R Battig and Yong Wang, 2014, "Polymerization of affinity ligands on a surface for enhanced ligand display and cell binding.", Biomacromolecules, 15, (12), pp. 4561-9
  • N Chen, Yuan-Han Huang and Yong Wang, 2014, "Bioinspired affinity DNA polymers on nanoparticles for drug sequestration and detoxification.", Biomaterials, 35, (36), pp. 9709-18
  • Mark Battig, Yike Huang, Niancao Chen and Yong Wang, 2014, "Aptamer-functionalized superporous hydrogels for sequestration and release of growth factors regulated via molecular recognition", Biomaterials, 35, (27), pp. 8040–8048
  • N Chen, S Li, M R Battig and Yong Wang, 2013, "Programmable imaging amplification via nanoparticle-initiated DNA polymerization.", Small, 9, (23), pp. 3944-9
  • K Fu, S Li, X Jiang, Yong Wang and B G Willis, 2013, "DNA gold nanoparticle nanocomposite films for chemiresistive vapor sensing.", Langmuir : the ACS journal of surfaces and colloids, 29, (46), pp. 14335-43
  • Xiaolong Zhang, M R Battig and Yong Wang, 2013, "Programmable hydrogels for the controlled release of therapeutic nucleic acid aptamers via reversible DNA hybridization.", Chemical communications (Cambridge, England), 49, (83), pp. 9600-2
  • Z Zhang, S Li, N Chen, Cheng Yang and Yong Wang, 2013, "Programmable display of DNA-protein chimeras for controlling cell-hydrogel interactions via reversible intermolecular hybridization.", Biomacromolecules, 14, (4), pp. 1174-80
  • S Li, N Chen, Zhihua Zhang and Yong Wang, 2013, "Endonuclease-responsive aptamer-functionalized hydrogel coating for sequential catch and release of cancer cells.", Biomaterials, 34, (2), pp. 460-9
  • Zhaoyang Zhang, N Chen, S Li, M R Battig and Yong Wang, 2012, "Programmable hydrogels for controlled cell catch and release using hybridized aptamers and complementary sequences.", Journal of the American Chemical Society, 134, (38), pp. 15716-9
  • M R Battig, B Soontornworajit and Yong Wang, 2012, "Programmable release of multiple protein drugs from aptamer-functionalized hydrogels via nucleic acid hybridization.", Journal of the American Chemical Society, 134, (30), pp. 12410-3
  • Xiaolong Zhang, B Soontornworajit, Zhaoyang Zhang, N Chen and Yong Wang, 2012, "Enhanced loading and controlled release of antibiotics using nucleic acids as an antibiotic-binding effector in hydrogels.", Biomacromolecules, 13, (7), pp. 2202-10
  • N Chen, Zhihua Zhang, B Soontornworajit, J Zhou and Yong Wang, 2012, "Cell adhesion on an artificial extracellular matrix using aptamer-functionalized PEG hydrogels.", Biomaterials, 33, (5), pp. 1353-62
  • L Li, K Crosby, Marianne Sawicki, LL Shaw and Yong Wang, 2012, "Effects of Surface Roughness of Hydroxyapatite on Cell Attachment and Proliferation", J Biotechnol Biomater, 2, (150), pp. 2
  • B Soontornworajit, J Zhou, M P Snipes, M R Battig and Yong Wang, 2011, "Affinity hydrogels for controlled protein release using nucleic acid aptamers and complementary oligonucleotides.", Biomaterials, 32, (28), pp. 6839-49
  • Weiqiang Cao, J Zhou, Andrea R Mann, Yong Wang and Lei Zhu, 2011, "Folate-functionalized unimolecular micelles based on a degradable amphiphilic dendrimer-like star polymer for cancer cell-targeted drug delivery.", Biomacromolecules, 12, (7), pp. 2697-707
  • B Soontornworajit and Yong Wang, 2011, "Nucleic acid aptamers for clinical diagnosis: cell detection and molecular imaging.", Analytical and bioanalytical chemistry, 399, (4), pp. 1591-9
  • J Zhou, B Soontornworajit, M P Snipes and Yong Wang, 2011, "Structural prediction and binding analysis of hybridized aptamers.", Journal of molecular recognition : JMR, 24, (1), pp. 119-26
  • Tai-Hsi Fan, Boonchoy Soontornworajit, Mehdi Karzar-Jeddi, Xiaolong Zhang and Yong Wang, 2011, "An aptamer-functionalized hydrogel for controlled protein release: A modeling study", Soft Matter, 7, (19), pp. 9326–9334
  • Wenwu Cao, J Zhou, Yong Wang and Lei Zhu, 2010, "Synthesis and in vitro cancer cell targeting of folate-functionalized biodegradable amphiphilic dendrimer-like star polymers.", Biomacromolecules, 11, (12), pp. 3680-7
  • J Zhou, M R Battig and Yong Wang, 2010, "Aptamer-based molecular recognition for biosensor development.", Analytical and bioanalytical chemistry, 398, (6), pp. 2471-80
  • B Soontornworajit, J Zhou, Zhaoyang Zhang and Yong Wang, 2010, "Aptamer-functionalized in situ injectable hydrogel for controlled protein release.", Biomacromolecules, 11, (10), pp. 2724-30
  • J Zhou, B Soontornworajit and Yong Wang, 2010, "A temperature-responsive antibody-like nanostructure.", Biomacromolecules, 11, (8), pp. 2087-93
  • B Soontornworajit, J Zhou, M T Shaw, T H Fan and Yong Wang, 2010, "Hydrogel functionalization with DNA aptamers for sustained PDGF-BB release.", Chemical communications (Cambridge, England), 46, (11), pp. 1857-9
  • Boonchoy Soontornworajit, Jing Zhou and Yong Wang, 2010, "A hybrid particle–hydrogel composite for oligonucleotide-mediated pulsatile protein release", Soft Matter, 6, (17), pp. 4255–4261
  • J Zhou, B Soontornworajit, J Martin, B A Sullenger, E Gilboa and Yong Wang, 2009, "A hybrid DNA aptamer-dendrimer nanomaterial for targeted cell labeling.", Macromolecular bioscience, 9, (9), pp. 831-5
  • J Zhou, B Soontornworajit, M P Snipes and Yong Wang, 2009, "Development of a novel pretargeting system with bifunctional nucleic acid molecules.", Biochemical and biophysical research communications, 386, (3), pp. 521-5
  • Yong Wang, 2009, "Engineering strategies for drug delivery [Introduction to the special issue]", IEEE Engineering in Medicine and Biology Magazine, 28, (1), pp. 10–11
  • Jing Zhou, Ren-He Xu and Yong Wang, 2009, "Nanoporous membrane-encapsulated feeder cells for culture of human embryonic stem cells", International Journal of Functional Informatics and Personalised Medicine, 2, (1), pp. 77–88
  • Cheng-Mao Lin, Yong Wang, P Challa, D L Epstein and F Yuan, 2007, "Transscleral diffusion of ethacrynic acid and sodium fluorescein.", Molecular vision, 13, pp. 243-51
  • J O McNamara, 2nd, E R Andrechek, Yong Wang, K D Viles, R E Rempel, E Gilboa, B A Sullenger and P H Giangrande, 2006, "Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras.", Nature biotechnology, 24, (8), pp. 1005-15
  • Yong Wang, H Wang, C Y Li and F Yuan, 2006, "Effects of rate, volume, and dose of intratumoral infusion on virus dissemination in local gene delivery.", Molecular cancer therapeutics, 5, (2), pp. 362-6
  • Yong Wang and F Yuan, 2006, "Delivery of viral vectors to tumor cells: extracellular transport, systemic distribution, and strategies for improvement.", Annals of biomedical engineering, 34, (1), pp. 114-27
  • Yong Wang, S Liu, C Y Li and F Yuan, 2005, "A novel method for viral gene delivery in solid tumors.", Cancer research, 65, (17), pp. 7541-5
  • Yong Wang, Zifeng Yang, S Liu, T Kon, A Krol, C Y Li and F Yuan, 2005, "Characterisation of systemic dissemination of nonreplicating adenoviral vectors from tumours in local gene delivery.", British Journal of Cancer, 92, (8), pp. 1414-20
  • Yong Wang, Qing Chen and Yuan Fan, 2005, "Alginate encapsulation is a highly reproducible method for tumor cell implantation in dorsal skinfold chamber", Biotechniques, 39, (6), pp. 834–838
  • Yong Wang, P Challa, D L Epstein and F Yuan, 2004, "Controlled release of ethacrynic acid from poly(lactide-co-glycolide) films for glaucoma treatment.", Biomaterials, 25, (18), pp. 4279-85
  • Yong Wang, J K Hu, A Krol, Y P Li, C Y Li and F Yuan, 2003, "Systemic dissemination of viral vectors during intratumoral injection.", Molecular cancer therapeutics, 2, (11), pp. 1233-42
  • Yong Wang, Yang He, Qun Liu, Jinyun Li and Xiaojun Ma, 2000, "Deacetylation of chitosan films", Chemical Journal on Internet, pp. 02b051ne
  • Y He, Y B Xie, Y Wang, Q Liu and X J Ma, 2000, "Improved Mathematical Model of APA Microcapsules", 21, (2), pp. 278-282
  • Yong Wang, Mingchun Li and Xiaojun Ma, 1999, "Influence of Reaction Time on the Preparation of Alginate/Chitosan Microcapsule", Chemical Journal on Internet, pp. c99060
  • Yong Wang, Yubing Xie and Xiaojun Ma, 1999, "Progress in Studies on Chitosan/Alginate Microcapsule", Progress in Biotechnology, 19, (2), pp. 13-20

Conference Proceedings

  • v Swaminathan, S Gannavaram, S Li, H Hu, J Yeom, Y Wang and L Zhu, 2013, "Microfluidic platform with hierarchical micro/nanostructures and SELEX nucleic acid aptamer coating for isolation of circulating tumor cells"
  • Y. Wang, CY Li and F Yuan, 2004, "Systemic virus dissemination during local gene delivery in solid tumors and its control with an alginate solution", 26, pp. 3524-3526
  • Yong Wang, JK Hu, A Krol, YP Li, CY Li and F Yuan, 2002, "Reducing systemic toxicity in local tumor gene therapy using an alginate solution", 1, pp. 565
  • CW Lin, Yong Wang and F Yuan, 2002, "Transscleral diffusion of ethacrynic acid and sodium fluorescein", 1, pp. 515
  • Y Wang, YB Xie, J Li, C Chi, B Han and XJ Ma, 1998, "Study on preparing the alginate/chitosan microcapsule", pp. 402-405


  • S. Li and Yong Wang, 2015, "A sustainable material for capturing and killing circulating tumor cells"
  • E. R. Gaddes, G Gydush and Yong Wang, 2015, "Aptamer-mediated capture and release of circulating tumor cells in dynamic conditions"
  • Y Wang, 2014, "Aptamer-functionalized non-fouling hydrogels for regulating cell-material interactions"
  • Y Wang, 2014, "Programmable hydrogels for drug delivery and regenerative medicine"
  • D Paglia, M Battig, H Drissi, Y Wang and M Moss, 2014, "rhPDGF-BB release from aptamer-functionalized superporous PEG hydrogels: a scaffold for matrix formation and potential disc repair"
  • M Battig, N. Chen and Yong Wang, 2013, "Superporous extracellular matrix mimics for on-demand release of growth factors based on nucleic acid aptamers and superporous hydrogels"
  • K N Boch, M Battig and Yong Wang, 2012, "Electro-responsive affinity hydrogels for controlled protein release"
  • Y Wang, Boonchoy Soontornworajit, M R Battig and N Chen, 2012, "Development of artificial extracellular matrix for sequential triggered release of multiple growth factors using aptamer and hydrogel"
  • N Chen and Yong Wang, 2012, "Development of artificial extracellular matrix for cell adhesion using aptamer and hydrogel"
  • Yong Wang, M R Battig, Boonchoy Soontornworajit and N Chen, 2012, "Aptamer-functionalized hydrogels for mimicking extracellular matrices"
  • s Li, N. Chen, Z Zhang and Y Wang, 2012, "Aptamer functionalized hydrogel coating for cell capture and release"
  • M R Battig, Boonchoy Soontornworajit, and Y. Wang, 2011, "Affinity Hydrogel for Controlled Protein Release: Tuning the Binding Capability of Aptamers"
  • N Chen and Y. Wang, 2011, "Hydrogel Functionalization with Nucleic Acid Aptamers for Cell Adhesion"
  • Z. Zhang, N. Chen, L Li and Y. Wang, 2011, "Aptamer-functionalized surface for cell separation"
  • T H Fan, Boonchoy Soontornworajit, M Karzar-Jeddi and Y Wang, 2011, "Modeling of Sustained Protein Release from Aptamer-Modified Hydrogels"
  • Boonchoy Soontornworajit, J. Zhou, M R Battig, Y Wang and, 2011, "Affinity Hydrogels for Controlling Protein Release via Intermolecular Hybridization"
  • W Cao, J Zhou, B Soontornworajit, Y Wang and L Zhu, 2010, "Synthesis of folate functionalized biodegradable amphiphilic dendrimer-like star polymer for targeted cancer cells"
  • Boonchoy Soontornworajit, J Zhou and Y Wang, 2010, "Pulsatile growth factor release from novel aptamer-functionalized composites"
  • B Soontornworajit, J Zhou and Y Wang, 2010, "Aptamer-decorated hydrogels for sustained protein release"
  • J Zhou, Boonchoy Soontornworajit and Y Wang, 2010, "A novel artificial antibody for reversible cell recognition"
  • B Soontornworajit, J Zhou and Y Wang, 2010, "Aptamer-functionalized biomaterials for pulsatile proteins release"
  • B Soontornworajit, J Zhou, Y Wang and T H Fan, 2010, "Sustained protein release from novel aptamer-functionalized hydrogels"
  • B Soontornworajit, M Karzar-Jeddi, Y Wang and T H Fan, 2010, "Modeling of sustained protein release from an aptamer-functionalized hydrogel"
  • J Zhou, B Soontornworajit and Y Wang, 2010, "A temperature-responsive synthetic antibody for reversible cell labeling"
  • B Soontornworajit, J Zhou and Y Wang, 2010, "Controlled protein release from aptamer-decorated hydrogels"
  • J Zhou, B Soontornworajit and Y Wang, 2010, "Antibody-like nanomaterials for cell recognition"
  • J Zhou,, B Soontornworajit and Y Wang, 2009, "Determining the essential nucleotides of an aptamer by using molecular guides"
  • J Zhou, B Soontornworajit and Y Wang, 2009, "Artificial antibody for cancer cell labeling"
  • J Zhou, B Soontornworajit and Y Wang, 2009, "Using molecular guides to identify the essential nanostructures of nucleic acid aptamers"
  • J Zhou, B Soontornworajit and Y Wang, 2009, "A DNA aptamer-based nanomaterial for targeted cell labeling"
  • J Zhou, B Soontornworajit and Y Wang, 2009, "Using nucleic acid aptamers to develop artificial antibodies for drug delivery"
  • F Yuan and Y Wang, 2005, "Systemic dissemination of viral vectors during and after intratumoral infusion"
  • Y Wang, CY Li and F Yuan, 2003, "Adenovirus dissemination in convection-enhanced delivery and its control with a polymeric vehicle"
  • F Yuan and Y Wang, 2002, "Controlled release of ethacrynic acid from PLGA films for glaucoma treatment"

Research Projects

Honors and Awards

  • Outstanding Research Award, The Penn State Engineering Alumni Society, September 2019 - 2019
  • Invitational Fellow, Japan Society for the Promotion of Sciences, October 2019 - December 2019


Service to Penn State:

Service to External Organizations:




The Department of Biomedical Engineering administers the undergraduate major in biomedical engineering, and is a part of the university-wide Intercollege Graduate Degree Program, offering both M.S. and Ph.D. degrees in Bioengineering. Our work combines traditional engineering principles with medicine and technology for the betterment of human health and society. 

Department of Biomedical Engineering

122 Chemical and Biomedical Engineering Building

The Pennsylvania State University

University Park, PA 16802-4400

Phone: 814-863-6614