Photo of Sri-Rajasekhar (Raj) Kothapalli

Sri-Rajasekhar (Raj) Kothapalli

Assistant Professor

Affiliation(s):

  • Biomedical Engineering

325 Chemical and Biomedical Engineering Building

szk416@psu.edu

814-865-0459

Personal or Departmental Website

Research Areas:

 
 

 

Education

  • BS, Math, Physics, Chemistry, Nagarjuna University, 1995
  • MS, Nuclear Physics, Andhra University, 1997
  • M Phil, Condensed Matter Physics, University of Hyderabad, 1998
  • M.Eng, Applied Optics, I.I.T Delhi, 2000
  • MS, Applied Physics, University of Massachusetts, Boston, 2004
  • Ph D, Biomedical Engineering, Washington University in St. Louis, 2009
  • Postdoctoral, Radiology, Stanford University, 2013

Publications

Journal Articles

  • Christopher Fadden and Sri-Rajasekhar Kothapalli, 2018, "A Single Simulation Platform for Hybrid Photoacoustic and RF-Acoustic Computed Tomography", APPLIED SCIENCES-BASEL, 8, (9)
  • Dingying Shan, Sri-Rajasekhar Kothapalli, Dino J. Ravnic, Ethan Gerhard, Jimin P. Kim, Jinshan Guo, Chuying Ma, Jiazhi Guo, Li Gui, Lin Sun, Di Lu and Jian Yang, 2018, "Development of Citrate-Based Dual-Imaging Enabled Biodegradable Electroactive Polymers", ADVANCED FUNCTIONAL MATERIALS, 28, (34)
  • Willemieke S. Tummers, Sarah E. Miller, Nutte T. Teraphongphom, Adam Gomez, Idan Steinberg, David M. Huland, Steve Hong, Sri-Rajasekhar Kothapalli, Alifia Hasan, Robert Ertsey, Bert A. Bonsing, Alexander L. Vahrmeijer, Rutger-Jan Swijnenburg, Teri A. Longacre, George A. Fisher, Sanjiv S. Gambhir, George A. Poultsides and Eben L. Rosenthal, 2018, "Intraoperative Pancreatic Cancer Detection using Tumor-Specific Multimodality Molecular Imaging", ANNALS OF SURGICAL ONCOLOGY, 25, (7), pp. 1880-1888
  • Man-Chia Chen, Aldo Pena Perez, Sri-Rajasekhar Kothapalli, Philippe Cathelin, Andreia Cathelin, Sanjiv Sam Gambhir and Boris Murmann, 2017, "A Pixel Pitch-Matched Ultrasound Receiver for 3-D Photoacoustic Imaging With Integrated Delta-Sigma Beamformer in 28-nm UTBB FD-SOI", IEEE JOURNAL OF SOLID-STATE CIRCUITS, 52, (11), pp. 2843-2856
  • Kai Cheng, Sri-Rajasekhar Kothapalli, Hongguang Liu, Ai Leen Koh, Jesse V. Jokerst, Han Jiang, Meng Yang, Jinbo Li, Jelena Levi, Joseph C. Wu, Sanjiv S. Gambhir and Zhen Cheng, 2014, "Construction and Validation of Nano Gold Tripods for Molecular Imaging of Living Subjects", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 136, (9), pp. 3560-3571
  • Anca Dragulescu-Andrasi, Sri-Rajasekhar Kothapalli, Grigory A. Tikhomirov, Jianghong Rao and Sanjiv S. Gambhir, 2013, "Activatable Oligomerizable Imaging Agents for Photoacoustic Imaging of Furin-Like Activity in Living Subjects", Journal of the American Chemical Society, 135, (30), pp. 11015-11022
  • Sarah E. Bohndiek, Sandhya Bodapati, Van De Sompel, Dominique, Sri-Rajasekhar Kothapalli and Sanjiv S. Gambhir, 2013, "Development and Application of Stable Phantoms for the Evaluation of Photoacoustic Imaging Instruments", PLOS ONE, 8, (9)
  • Gary Shambat, Sri-Rajasekhar Kothapalli, J. Provine, Tomas Sarmiento, James Harris, Sanjiv Sam Gambhir and Jelena Vuckovic, 2013, "Single-Cell Photonic Nanocavity Probes", NANO LETTERS, 13, (11), pp. 4999-5005
  • Gary Shambat, Sri Rajasekhar Kothapalli, Aman Khurana, J. Provine, Tomas Sarmiento, Kai Cheng, Zhen Cheng, James Harris, Heike Daldrup-Link, Sanjiv Sam Gambhir and Jelena Vuckovic, 2012, "A photonic crystal cavity-optical fiber tip nanoparticle sensor for biomedical applications", APPLIED PHYSICS LETTERS, 100, (21)
  • Sri-Rajasekhar Kothapalli, Te-Jen Ma, Srikant Vaithilingam, Oemer Oralkan, Butrus T. Khuri-Yakub and Sanjiv Sam Gambhir, 2012, "Deep Tissue Photoacoustic Imaging Using a Miniaturized 2-D Capacitive Micromachined Ultrasonic Transducer Array", IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 59, (5), pp. 1199-1204
  • Sri-Rajasekhar Kothapalli, Hongguang Liu, Joseph C. Liao, Zhen Cheng and Sanjiv Sam Gambhir, 2012, "Endoscopic imaging of Cerenkov luminescence", BIOMEDICAL OPTICS EXPRESS, 3, (6), pp. 1215-1225
  • T J Ma, Sri-Rajasekhar Kothapalli, S Vaithilingam, O Oralkan, A Kamaya, I O Wygant, X Zhuang, S S Gambhir, R B Jeffrey, Jr and B T Khuri-Yakub, 2010, "3-D Deep Penetration Photoacoustic Imaging with a 2-D CMUT Array.", Proceedings. IEEE Ultrasonics Symposium, 2010, pp. 375-377
  • Xiao Xu, Sri-Rajasekhar Kothapalli, Honglin Liu and Lihong V. Wang, 2010, "Errata: Spectral hole burning for ultrasound-modulated optical tomography of thick tissue", Journal of Biomedical Optics, 15, (6), pp. 069801
  • Jelena Levi, Sri Rajasekhar Kothapalli, Te-Jen Ma, Keith Hartman, Butrus T. Khuri-Yakub and Sanjiv Sam Gambhir, 2010, "Design, Synthesis, and Imaging of an Activatable Photoacoustic Probe", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 132, (32), pp. 11264-11269
  • Chandra S. Yelleswarapu and Sri-Rajasekhar Kothapalli, 2010, "Nonlinear photoacoustics for measuring the nonlinear optical absorption coefficient", OPTICS EXPRESS, 18, (9), pp. 9020-9025
  • Xiao Xu, Sri-Rajasekhar Kothapalli, Honglin Liu and Lihong V. Wang, 2010, "Spectral hole burning for ultrasound-modulated optical tomography of thick tissue", JOURNAL OF BIOMEDICAL OPTICS, 15, (6)
  • Chandra S. Yelleswarapu, Marla Tipping, Sri-Rajasekhar Kothapalli, Alexey Veraksa, Rao and D. V. G. L. N., 2009, "Common-path multimodal optical microscopy", OPTICS LETTERS, 34, (8), pp. 1243-1245
  • Sri-Rajasekhar Kothapalli and Lihong V. Wang, 2009, "Ex vivo blood vessel imaging using ultrasound-modulated optical microscopy", JOURNAL OF BIOMEDICAL OPTICS, 14, (1)
  • Chandra S. Yelleswarapu, Sri-Rajasekhar Kothapalli, Rao and D. V. G. L. N., 2008, "Optical Fourier techniques for medical image processing and phase contrast imaging", OPTICS COMMUNICATIONS, 281, (7), pp. 1876-1888
  • Sri-Rajasekhar Kothapalli and Lihong V. Wang, 2008, "Ultrasound-modulated optical microscopy", JOURNAL OF BIOMEDICAL OPTICS, 13, (5)
  • Sri-Rajasekhar Kothapalli, Sava Sakadzic, Chulhong Kim and Lihong V. Wang, 2007, "Imaging optically scattering objects with ultrasound-modulated optical tomography", OPTICS LETTERS, 32, (16), pp. 2351-2353
  • Chandra S. Yelleswarapu, Pengfei Wu, Sri-Rajasekhar Kothapalli and D. V. Rao, 2006, "Nonlinear Optical Image Processing with Bacteriorhodopsin Polymer Films", Molecular Crystals and Liquid Crystals, 446, (1), pp. 273-294
  • C Yelleswarapu, P Wu, Sri-Rajasekhar Kothapalli, D V Rao, B Kimball, S S Sai, R Gowrishankar and S Sivaramakrishnan, 2006, "All-optical spatial filtering with power limiting materials.", Optics express, 14, (4), pp. 1451-7
  • Chandra S. Yelleswarapu, Sri-Rajasekhar Kothapalli, Francisco J. Aranda, Rao, D. V. G. L. N., Yvonne R. Vaillancourt and Brian R. Kimball, 2006, "Phase contrast imaging using photothermally induced phase transitions in liquid crystals", APPLIED PHYSICS LETTERS, 89, (21)
  • Sri-Rajasekhar Kothapalli, Chandra S. Yelleswarapu, Sriram G. Naraharisetty, Pengfei Wu and D.V.G.L.N. Rao, 2005, "Spectral Phase Based Medical Image Processing1", Academic Radiology, 12, (6), pp. 708-721
  • Sri-Rajasekhar Kothapalli, Pengfei Wu, Chandra S. Yelleswarapu and D. V. Rao, 2005, "Nonlinear optical Fourier filtering technique for medical image processing", Journal of Biomedical Optics, 10, (4), pp. 044028
  • Sri-Rajasekhar Kothapalli, Pengfei Wu, Chandra S. Yelleswarapu and D. V. Rao, 2004, "Medical image processing using transient Fourier holography in bacteriorhodopsin films", Applied Physics Letters, 85, (24), pp. 5836-5838
  • D. Narayana Rao, Chandra Yelleswarapu, Sri-Rajasekhar Kothapalli, D. Rao and Brian Kimball, 2003, "Self-diffraction in bacteriorhodopsin films for low power optical limiting", Optics Express, 11, (22), pp. 2848

Conference Proceedings

  • Ajay Dangi, Sumit Agrawal, Sudhanshu Tiwari, Shubham Jadhav, Christopher Cheng, Susan E Trolier-McKinstry, Rudra Pratap and Sri-Rajasekhar Kothapalli, 2018, "Evaluation of High Frequency Piezoelectric Micromachined Ultrasound Transducers for Photoacoustic Imaging", IEEE
  • Ajay Dangi, Sumit Agrawal, Jedidiah Lieberknecht, Jason Zhang and Sri-Rajasekhar Kothapalli, 2018, "Ring Ultrasound Transducer Based Miniaturized Photoacoustic Imaging System", IEEE
  • Idan Steinberg, David M. Huland, Sanjiv S. Gambhir, Willemieke Tummers and Sri Rajasekhar Kothapalli, 2018, "A model-based acoustic reconstruction algorithm for deep tissue clinical photoacoustic imaging of cancerous tissues labeled with contrast agents (Conference Presentation)", SPIE
  • Man-Chia Chen, Aldo Pena Perez, Sri-Rajasekhar Kothapalli, Philippe Cathelin, Andreia Cathelin, Sanjiv Sam Gambhir and Boris Murmann, 2017, "27.5 A pixel-pitch-matched ultrasound receiver for 3D photoacoustic imaging with integrated delta-sigma beamformer in 28nm UTBB FDSOI", IEEE
  • Man-Chia Chen, Aldo Pena Perez, Sri-Rajasekhar Kothapalli, Philippe Cathelin, Andreia Cathelin, Sanjiv Sam Gambhir and Boris Murmann, 2017, "A Pixel-Pitch-Matched Ultrasound Receiver for 3D Photoacoustic Imaging with Integrated Delta-Sigma Beamformer in 28nm UTBB FDSOI", 2017 IEEE INTERNATIONAL SOLID-STATE CIRCUITS CONFERENCE (ISSCC), pp. 456-456
  • Devulapalli Rao, Sri-Rajasekar Kothapalli, Pengfei Wu and Chandra Yelleswarapu, 2013, "Transient Fourier holography with bacteriorhodopsin films for breast cancer diagnostics", SPIE
  • Sarah E. Bohndiek, Dominique Van de Sompel, Sandhya Bodapati, Sri Rajasekhar Kothapalli and Sanjiv S. Gambhir, 2013, "Stable phantoms for characterization of photoacoustic tomography (PAT) systems", SPIE
  • Sarah E. Bohndiek, Van De Sompel, Dominique, Sandhya Bodapati, Sri Rajasekhar Kothapalli and Sanjiv S. Gambhir, 2013, "Stable phantoms for characterization of photoacoustic tomography (PAT) systems", DESIGN AND PERFORMANCE VALIDATION OF PHANTOMS USED IN CONJUNCTION WITH OPTICAL MEASUREMENT OF TISSUE V, 8583
  • Devulapalli Rao, Sri-Rajasekhar Kothapalli, Pengfei Wu and Chandra Yelleswarapu, 2013, "Transient Fourier holography with Bacteriorhodopsin films for breast cancer diagnostics", BIOINSPIRED, BIOINTEGRATED, BIOENGINEERED PHOTONIC DEVICES, 8598
  • Amin Nikoozadeh, Jung Woo Choe, Sri-Rajasekhar Kothapalli, Azadeh Moini, Sahinaz S. Sanjani, Aya Kamaya, Omer Oralkan, Sanjiv S. Gambhir and Pierre T. Khuri-Yakub, 2012, "Photoacoustic imaging using a 9F microLinear CMUT ICE catheter", IEEE
  • Amin Nikoozadeh, Jung Woo Choe, Sri-Rajasekhar Kothapalli, Azadeh Moini, Sahinaz S. Sanjani, Aya Kamaya, Oemer Oralkan, Sanjiv S. Gambhir and Pierre T. Khuri-Yakub, 2012, "Photoacoustic Imaging Using a 9F MicroLinear CMUT ICE Catheter", 2012 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS), pp. 24-27
  • Chandra S. Yelleswarapu, Sri-Rajasekhar Kothapalli and D. V. Rao, 2011, "Photoacoustic Z-scan for the measurement of third-order nonlinear absorption coefficient", SPIE
  • Te-Jen Ma, Sri Rajasekhar Kothapalli, Srikant Vaithilingam, Omer Oralkan, Aya Kamaya, Ira O. Wygant, Xuefeng Zhuang, Sanjiv S. Gambhir, R. Brooke Jeffrey and Butrus T. Khuri-Yakub, 2010, "3-D Deep penetration photoacoustic imaging with a 2-D CMUT array", IEEE
  • Sri-Rajasekhar Kothapalli and Lihong V. Wang, 2009, "Ultrasound-modulated optical microscopy for ex vivo imaging of scattering biological tissue", PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2009, 7177
  • Sri-Rajasekhar Kothapalli, Sava Sakadzic, Chulhong Kim and Lihong V. Wang, 2008, "Imaging of optical scattering contrast using ultrasound-modulated optical tomography", PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2008: THE NINTH CONFERENCE ON BIOMEDICAL THERMOACOUSTICS, OPTOACOUSTICS, AND ACOUSTIC-OPTICS, 6856
  • Chulhong Kim, Alejandro Garcia-Uribe, Sri-Rajasekhar Kothapalli and Lihong V. Wang, 2008, "Optical phantoms for ultrasound-modulated optical tomography", DESIGN AND PERFORMANCE VALIDATION OF PHANTOMS USED IN CONJUNCTION WITH OPTICAL MEASUREMENTS OF TISSUE, 6870
  • Sava Sakadzic, Sri-Rajasekhar Kothapalli and Lihong V. Wang, 2006, "Towards very high resolution imaging in ultrasound-modulated optical tomography of biological tissues", PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2006, 6086
  • Chandra S. Yelleswarapu, Sri-Rajasekhar Kothapalli, Pengfei Wu and D. V. Rao, 2006, "Photo-controlled absorption in Bacteriorhodopsin films for medical image processing", IEEE

Other

  • Leong, Stanley P. L., Sri-Rajasekhar Kothapalli and Sanjiv Sam Gambhir, 2016, "Can multispectral optoacoustic tomography replace sentinel lymph biopsy in melanoma?", ANNALS OF TRANSLATIONAL MEDICINE, 4, (24)
  • Xiao Xu, Sri-Rajasekhar Kothapalli, Honglin Liu and Lihong V. Wang, 2010, "Spectral hole burning for ultrasound-modulated optical tomography of thick tissue (vol 15, 066018, 2010)", JOURNAL OF BIOMEDICAL OPTICS, 15, (6)

Research Projects

  • July 2017 - June 2020, "Transrectal Ultrasound and Photoacoustic Imaging of Prostate and Molecular Imaging Approaches," (Sponsor: National Institute of Biomedical Imaging and Bioengineering).

Honors and Awards

  • NIH Pathway to Indepedence Grant Award K99/R00, National Institute of Health, May 2014 - August 2020

Service

Service to Penn State:

Service to External Organizations:

 


 

About

The Department of Biomedical Engineering administers the undergraduate major in biomedical engineering, and is a part of the university-wide Intercollege Graduate Degree Program, offering both M.S. and Ph.D. degrees in Bioengineering. Our work combines traditional engineering principles with medicine and technology for the betterment of human health and society. 

Department of Biomedical Engineering

122 Chemical and Biomedical Engineering Building

The Pennsylvania State University

University Park, PA 16802-4400

Phone: 814-863-6614