• BS, Bioengineering, Texas A&M University, 1995
• MS, Bioengineering, Texas A&M University, 1997
• Ph D, Biomedical Engineering, Virginia Commonwealth University, 2001
• Post Doctoral Scholar, Bioengineering, The Pennsylvania State University, 2004

Journal Articles

Cody Kubicki, Emma Raich, Peter Selinskry, Sailahari Ponnaluri, Steven Deutsch, William J Weiss and Keefe B Manning, 2024, "Fluid Dynamic Study of the Penn State Pediatric Total Artificial Heart", ASME Journal of Biomechanical Engineering, 146, (10), pp. 101007

Priyanka Patki, Scott Simon, Francesco Costanzo and Keefe B Manning, 2024, "Current Approaches and Methods to Understand Acute Ischemic Stroke Treatment Using Aspiration Thrombectomy", Cardiovasc Eng Tech

Boyang Su, Hannah Palahnuk, Thaddeus Harbaugh, Elias Rizk, S Will Hazard, Angel Chan, Jonathan Bernstein, Jonathan W Weinsaft and Keefe B Manning, 2024, "Numerical study on the impact of central venous catheter placement on blood flow in the cavo-atrial junction", Ann Biomed Eng, 52, (5), pp. 1378-1392

Connor Watson, Hicham Saaid, Vijay Vedula, Jessica C Cardenas, Peter K Henke, Franck Nicoud, Xiao Yun Yu, Beverley J Hunt and Keefe B Manning, 2024, "Venous Thromboembolism: Review of Clinical Challenges, Biology, Assessment, Treatment, and Modeling", Ann Biomed Eng, 52, (3), pp. 467-486

Connor T Watson, Shane C Ward, Stefano A Rizzo, Alberto Redaelli and Keefe B Manning, 2024, "Influence of Hematocrit Level and Integrin aIIbßIII Function on vWF-Mediated Platelet Adhesion and Shear-Induced Platelet Aggregation in a Sudden Expansion", Cell Mol Bioeng, 17, (1), pp. 49-65

Sailahari V Ponnaluri, Brady L Houtz, Emma C Raich, Bryan C Good, Steven Deutsch, William J Weiss and Keefe B Manning, 2023, "Effect of Hematocrit and Elevated Beat Rate on the 12cc Penn State Pediatric Ventricular Assist Device", ASAIO Journal, 69, (12), pp. 1065-1073

Nicolas Tobin, Menghan Li, Gretchen Hiller, Arash Azimi and Keefe B Manning, 2023, "Clot embolization studies and computational framework for embolization in a canonical tube model", Scientific Reports, 13, pp. 14682

Alberto Mantegazza, Nicolas Tobin, Keefe B Manning and Brent A Craven, 2023, "Examining the universality of the hemolysis power law model from simulations of the FDA nozzle using calibrated model coefficients", Biomech Model Mechanobiol, 22, (2), pp. 433-451

Connor T Watson, Lidya Abune, Hicham Saaid, Yong Wang and Keefe B Manning, 2023, "Performance of a hydrogel coated nitinol with oligonucleotide-modified nanoparticles within turbulent conditions of blood-contacting devices", Cardiovasc Eng Technol, 14, (2), pp. 239-251

Sailahari Ponnaluri, Michael S Sacks and Keefe B Manning, 2023, "The Accelerated Transcatheter Heart Valve Testing Environment: Loading, Motion, and Fluid Dynamics", ASME J Biomech Eng, 145, (3), pp. 031005

Saurabh Bhardwaj, Brent A Craven, Jacob E Sever, Francesco Costanzo, Scott D Simon and Keefe B Manning, 2023, "Modeling Flow in an In Vitro Anatomical Cerebrovascular Model with Experimental Validation", Frontiers of Medical Technology, 5, pp. 1130201

Priyanka Patki, Scott Simon, Keefe B Manning and Francesco Costanzo, 2023, "Computational analysis of effects of clot length on acute ischemic stroke recanalization under different cyclic aspiration loading conditions", Inter J Num Meth Biomed Eng, 39, (2), pp. e3667

Sailahari Ponnaluri, Prasanna Hariharan, Luke H Herbertson, Keefe B Manning, Richard A Malinauskas and Brent A Craven, 2023, "Results of the interlaboratory computational fluid dynamics study of the FDA benchmark blood pump", Ann Biomed Eng, 51, (1), pp. 253-269

Bryan C Good, Sailahari Ponnaluri, William J Weiss and Keefe B Manning, 2022, "Computational modeling of the Penn State Fontan circulation assist device", ASAIO Journal, 68, (12), pp. 1513-1522

A Lawanprasert, S Pimchareon, S E Sumner, C T Watson, Keefe B Manning, G S Kirimanjeswara and S H Medina, 2022, "Heparin-peptide nanogranules for thrombosis-actuated anticoagulation", Small, 18, (46), pp. e2203751

Nicolas Tobin and Keefe B Manning, 2022, "Toward modeling thrombosis and thromboembolism in laminar and turbulent flow regimes", Inter J Num Meth Biomed Eng, 38, (10), pp. e3638

Nicolas Tobin, Bryan C Good, Jonathan D Plasencia, Mark Fogel, William J Weiss and Keefe B Manning, 2022, "Computational Investigation of Anastomosis Options of a Right-Heart Pump to Patient Specific Pulmonary Arteries", Ann Biomed Eng, 50, (8), pp. 929-940

Sailahari Ponnaluri, Emma Christensen, Bryan C Good, Cody Kubicki, Steven Deutsch, Joshua Peter Cysyk, William J Weiss and Keefe B Manning, 2022, "Experimental Hemodynamics Within the Penn State Fontan Circulatory Assist Device", Journal of Biomechanical Engineering, 144, (7), pp. 071004

Keefe B Manning, Fran Nicoud and Susan M Shea, 2021, "Mathematical and computational modelling of device-induced thrombosis", Curr Opin Biomed Eng, pp. 100349

Oyekola Oyekole, Scott D Simon, Keefe B Manning and Francesco Costanzo, 2021, "Modeling Acute Ischemic Stroke Recanalization through Cyclic Aspiration", Journal of Biomechanics, 128, pp. 110721

Sailahari V Ponnaluri, Steven Deutsch, Michael S Sacks and Keefe B Manning, 2021, "Transcatheter Heart Valve Downstream Fluid Dynamics in an Accelerated Evaluation Environment", Ann Biomed Eng, 49, (9), pp. 2170-2182

Janna N Sloand, Eric Z Rokni, Connor T Watson, Keefe B Manning, Julianna Simon and Scott Medina, 2021, "Ultrasound-Responsive Nanopeptisomes Enable Synchronous Spatial Imaging and Inhibition of Clot Growth in Deep Vein Thrombosis", Adv Healthcare Materials, e2100520

Joshua M Riley, Nichole S Price, Hicham M Saaid, Bryan C Good, Kenneth I Aycock, Brent A Craven and Keefe B Manning, 2021, "In Vitro Clot Trapping Efficiency of the FDA Generic Inferior Vena Cava Filter in a Patient-Averaged Anatomical Model: An Experimental Fluid-Structure Interaction Benchmark", Cardiovascular Engineering and Technology, 12, (3), pp. 339-352

Choon-Sik Jhun, Raymond K Newswanger, Joshua Peter Cysyk, Sailahari Ponnaluri, Bryan C Good, Keefe B Manning and Gerson Rosenberg, 2021, "Dynamics of Blood Flows in Aortic Stenosis: Mild, Moderate, and Severe", ASAIO Journal, 67, (6), pp. 666-674

Ling Yang, Thomas Neuberger and Keefe B Manning, 2021, "In Vitro Real-Time Magnetic Resonance Imaging for Quantification of Thrombosis", MAGMA, 34, (2), pp. 285-295

Ling Yang, Nicolas Tobin and Keefe B Manning, 2021, "Refining a Numerical Model for Device-Induced Thrombosis and Investigating the Effects of Non-Newtonian Blood Models", Journal of Biomechanics, 120, pp. 110393

Bryan C Good, Francesco Costanzo, Scott D Simon and Keefe B Manning, 2020, "Hydrodynamics in Acute Ischemic Stroke Catheters under Static and Cyclic Aspiration Conditions", Cardiovascular Engineering and Technology

Bryan C Good and Keefe B Manning, 2020, "Computational Modeling of the Food and Drug Administration’s Benchmark Centrifugal Blood Pump", Artificial Organs, 44, (7), pp. E263-E276

Nicholas Tobin and Keefe B Manning, 2020, "Large-Eddy Simulations of Flow in the FDA Benchmark Nozzle Geometry to Predict Hemolysis", Cardiovascular Engineering and Technology, 11, (3), pp. 254-267

Gerson Rosenberg, Christopher A Siedlecki, Choon-Sik Jhun, William J Weiss, Keefe B Manning, Steven Deutsch and William Pierce, 2018, "Acquired Von Willebrand Syndrome (AVWS) and Blood Pump Design", Artificial Organs, 42, (12), pp. 1119-1124

Prasanna Hariharan, Kenneth I Aycock, M Buesen, Steven W Day, Bryan C Good, Luke H Herbertson, Ulrich Steinseifer, Keefe B Manning, Brent A Craven and Richard A Malinauskus, 2018, "Inter-Laboratory Characterization of the Velocity Field in the FDA Blood Pump Model Using Particle Image Velocimetry (PIV)", Cardiovasc Eng Technol, 9, (4), pp. 623-640

Maureen B Gallagher, Kenneth I Aycock, Brent A Craven and Keefe B Manning, 2018, "Steady Flow in a Patient-Averaged Inferior Vena Cava-Part I: Particle Image Velocimetry Measurements at Rest and Exercise Conditions", Cardiovasc Eng Technol, 9, (4), pp. 641-653

Brent A Craven, Kenneth I Aycock and Keefe B Manning, 2018, "Steady Flow in a Patient-Averaged Inferior Vena Cava-Part II: Computational Fluid Dynamics Verification and Validation", Cardiovasc Eng Technol, 9, (4), pp. 654-673

Choon-Sik Jhun, Megan Stauffer, John D Reibson, Eric E Yeager, Raymond K Newswanger, Joshua O Taylor, Keefe B Manning, William J Weiss and Gerson Rosenberg, 2018, "Determination of Reynolds Shear Stress Level for Hemolysis", ASAIO Journal, 64, (1), pp. 63-69

Elisabetta Tedaldi, Chiara Montanari, Kenneth I Aycock, Francesco Sturla, Alberto Redaelli and Keefe B Manning, 2018, "An experimental and computational study of the inferior vena cava hemodynamics under respiratory-induced collapse of the infrarenal IVC", Med Eng Phys, 54, pp. 44-55

Grant W Rowlands, Bryan C Good, Steven Deutsch and Keefe B Manning, 2018, "Characterizing the HeartMate II Left Ventricular Assist Device Outflow Using Particle Image Velocimetry", Journal of Biomechanical Engineering, 140, (7), pp. 071008

Kenneth I Aycock, Robert L Campbell, Frank C Lynch, Keefe B Manning and Brent A Craven, 2018, "Computational Predictions of the Embolus-Trapping Performance of an IVC Filter in Patient-Specific and Idealized IVC Geometries", Biomech Model Mechanobiol, 16, (6), pp. 1957-1969

Richard A Malinauskus, Prasanna Hariharan, Steven Day, Luke H Herbertson, Martin Buesen, Ulrich Steinseifer, Kenneth I Aycock, Bryan C Good, Steven Deutsch, Keefe B Manning and Brent A Craven, 2017, "FDA benchmark medical device flow models for CFD validation", ASAIO J, 63, (2), pp. 150-160

Kenneth I Aycock, Robert L Campbell, Keefe B Manning and Brent A Craven, 2017, "A Coupled CFD/6DoF Approach for Predicting Embolus Transport and the Embolus-Trapping Efficiency of IVC Filters", Biomech Model Mechanobiol, 16, pp. 851-869

Joshua O Taylor, Ling Yang, Steven Deutsch, Keefe B Mann andng, , 2017, "Development of a platelet adhesion transport equation for a computational thrombosis model", J Biomech, 50, pp. 114-120

Bryan C Good, William J Weiss, Steven Deutsch and Keefe B Manning, 2017, "Asynchronous Pumping of a Pulsatile Ventricular Assist Device in a Pediatric Anastomosis Model", World Journal for Pediatric and Congenital Heart Surgery, 8, (4), pp. 511-519

Alessandro Caimi, Francesco Sturla, Bryan C Good, Marco Vidotto, Rachele De Ponti, Filippo Piatti, Keefe B Manning and Alberto Redaelli, 2017, "Toward the virtual benchmarking of pneumatic ventricular assist devices: application of a novel FSI-based strategy to the Penn State 12 cc device", J Biomech Eng, 139, (8), pp. 4036936

Kenneth I Aycock, Robert L Campbell, Frank Lynch, Keefe B Manning, Brent A Cra anden, , 2016, "The Importance of Hemorheology and Patient Anatomy on the Hemodynamics in the Inferior Vena Cava", Annals of Biomedical Engineering, 44, (12), pp. 3568-3582

Bryan C Good, Steven Deutsch and Keefe B Manning, 2016, "Erratum to: Continuous and pulsatile pediatric ventricular assist device hemodynamics with a viscoelastic blood model", Cardiovascular Engineering and Technology, 7, (3), pp. 305-307

Joshua O Taylor, Bryan C Good, Anthony V Paterno, Prasana Hariharan, Steven Deutsch, Richard A Malinauskas and Keefe B Manning, 2016, "Analysis of transitional and turbulent flow through the FDA benchmark nozzle model using laser Doppler velocimetry", Cardiovasc Eng Technol, 7, (3), pp. 191-209

B C Good, S Deutsch and Keefe B Manning, 2016, "Hemodynamics in a pediatric ascending aorta using viscoelastic pediatric blood model", Annals of Biomedical Engineering, 44, (4), pp. 1019-1035

B C Good, S Deutsch and Keefe B Manning, 2016, "Continuous and pulsatile pediatric ventricular assist device hemodynamics with a viscoelastic blood model", Cardiovasc Eng Technol, 7, (1), pp. 23-43

J O Taylor, R S Meyer, S Deutsch and Keefe B Manning, 2016, "Development of a computational model for macroscopic predictions of device-induced thrombosis", Biomech Model Mechanobiol, 15, pp. 1713–1731

A R de Biasi, Keefe B Manning and A Salemi, 2015, "Time to cool off on a hot topic? Let's not forget about evidence when discussing heat-induced pump thrombogenesis.", The Journal of Heart and Lung Transplantation : The Official Publication of the International Society for Heart Transplantation, 34, (4), pp. 623-4

A R de Biasi, Keefe B Manning and A Salemi, 2015, "Science for surgeons: understanding pump thrombogenesis in continuous-flow left ventricular assist devices.", The Journal of Thoracic and Cardiovascular Surgery, 149, (3), pp. 667-73

N Masoumi, N Annabi, A Assmann, B L Larson, J Hjortnaes, N Alemdar, M Kharaziha, Keefe B Manning, J E Mayer, Jr and A Khademhosseini, 2014, "Tri-layered elastomeric scaffolds for engineering heart valve leaflets.", Biomaterials, 35, (27), pp. 7774-85

K I Aycock, Robert L Campbell, Keefe B Manning, S P Sastry, Suzanne M Shontz, F C Lynch and B A Craven, 2014, "A computational method for predicting inferior vena cava filter performance on a patient-specific basis.", Journal of Biomechanical Engineering, 136, (8)

J O Taylor, K P Witmer, Thomas Neuberger, B A Craven, Richard S Meyer, S Deutsch and Keefe B Manning, 2014, "In vitro MRI experiments of thrombus growth and computational simulations of the associated thrombus surface shear stresses in a backward-facing step geometry", Journal of Biomechanical Engineering, 136, (7)

N Masoumi, B L Larson, N Annabi, M Kharaziha, B Zamanian, K S Shapero, A T Cubberley, G Camci-Unal, Keefe B Manning, J E Mayer, Jr and A Khademhosseini, 2014, "Electrospun PGS:PCL microfibers align human valvular interstitial cells and provide tunable scaffold anisotropy.", Advanced Healthcare Materials, 3, (6), pp. 929-39

S R Topper, M A Navitsky, Richard B Medvitz, Eric G Paterson, Christopher A Siedlecki, Margaret J Slattery, S Deutsch, Gerson Rosenberg and Keefe B Manning, 2014, "The use of fluid mechanics to predict regions of microscopic thrombus formation in pulsatile VADs", Cardiovascular Engineering and Technology, 5, (1), pp. 54-69

M. A. Navitsky, J O Taylor, A B Smith, M J Slattery, S Deutsch, C A Siedlecki and Keefe B Manning, 2014, "Platelet adhesion to polyurethane urea under pulsatile flow conditions.", Artificial Organs, 38, (12), pp. 1047-1053

M A Navitsky, S Deutsch and Keefe B Manning, 2013, "A thrombus susceptibility comparison of two pulsatile Penn State 50 cc left ventricular assist device designs.", Annals of Biomedical Engineering, 41, (1), pp. 4-16

N. Masoumi, B. P. Larson, N. Annabi, M. Kharaziha, B. Zamanian, K. S. Shapero, A. T. Cubberley, G. Camci-Unal, Keefe B Manning, J. E. Mayer Jr. and A. Khademhosseini, 2013, "Electrospun PGS: Microfibers align human valvular interstitial cells and provide tunable scaffold anisotropy", Advanced Healthcare Materials, pp. 1-36

S. F.C. Stewart, P. Hariharan, E. G. Paterson, G. W. Burgreen, V. Reddy, S. W. Day, M. Giarra, Keefe B Manning, S. Deutsch, M. R. Berman, M. R. Myers and R. A. Malinauskas, 2013, "Results of FDA’s first interlaboratory computational study of a nozzle with a sudden contraction and conical diffuser", Cardiovascular Engineering and Technology, 4, (4), pp. 374-391

M Schönberger, S Deutsch and Keefe B Manning, 2012, "The influence of device position on the flow within the Penn State 12 cc pediatric ventricular assist device.", ASAIO Journal (American Society for Artificial Internal Organs, 58, (5), pp. 481-93

T C Long, J J Pearson, A C Hankinson, S Deutsch and Keefe B Manning, 2012, "An in vitro fluid dynamic study of pediatric cannulae: the value of animal studies to predict human flow.", Journal of Biomechanical Engineering, 134, (4), pp. 044501

F. C. Stewart, E. G. Paterson, G. W. Burgreen, P. Hariharan, M. Giarra, V. Reddy, S. W. Day, Keefe B Manning, S. Deutsch, M. R. Berman, M. R. Myers and R. A. Malinauskas, 2012, "Assessment of CFD performance in simulations of an idealized medical device results of FDAs first computational interlaboratory study", Cardiovascular Engineering and Technology, 3, (2), pp. 139-160

J C Nanna, M A Navitsky, S R Topper, S Deutsch and Keefe B Manning, 2011, "A fluid dynamics study in a 50?cc pulsatile ventricular assist device: influence of heart rate variability.", Journal of Biomechanical Engineering, 133, (10), pp. 101002

J C Nanna, J A Wivholm, S Deutsch and Keefe B Manning, 2011, "Flow field study comparing design iterations of a 50 cc left ventricular assist device.", ASAIO Journal (American Society for Artificial Internal Organs : 1992), 57, (5), pp. 349-57

C M Zapanta, H S Borovetz, M J Lysaght and Keefe B Manning, 2011, "How to teach artificial organs.", ASAIO (American Society for Artificial Internal Organs) Journal, 57, (5), pp. 466-9

L H Herbertson, S Deutsch and Keefe B Manning, 2011, "Near valve flows and potential blood damage during closure of a bileaflet mechanical heart valve.", Journal of Biomechanical Engineering, 133, (9), pp. 094507

B N Roszelle, S Deutsch, William J Weiss and Keefe B Manning, 2011, "Flow visualization of a pediatric ventricular assist device during stroke volume reductions related to weaning.", Annals of Biomedical Engineering, 39, (7), pp. 2046-58

P Hariharan, M Giarra, V Reddy, S W Day, Keefe B Manning, S Deutsch, S F Stewart, M R Myers, M R Berman, G W Burgreen, Eric G Paterson and R A Malinauskas, 2011, "Multilaboratory particle image velocimetry analysis of the FDA benchmark nozzle model to support validation of computational fluid dynamics simulations.", Journal of Biomechanical Engineering, 133, (4), pp. 041002

B. N. Roszelle, M. G. Fickes, S. Deutsch and Keefe B Manning, 2011, "Flow visualization of the Penn State pulsatile pediatric ventricular assist device cannulae and change in outlet valve placement", Cardiovascular Engineering and Technology, 2, (4), pp. 244-252

B N Roszelle, S Deutsch and Keefe B Manning, 2010, "A parametric study of valve orientation on the flow patterns of the Penn State pulsatile pediatric ventricular assist device.", ASAIO Journal (American Society for Artificial Internal Organs : 1992), 56, (4), pp. 356-63

B T Cooper, B N Roszelle, T C Long, S Deutsch and Keefe B Manning, 2010, "The influence of operational protocol on the fluid dynamics in the 12 cc Penn state pulsatile pediatric ventricular assist device: the effect of end-diastolic delay.", Artificial Organs, 34, (4), pp. E122-33

D Bluestein, K B Chandran and Keefe B Manning, 2010, "Towards non-thrombogenic performance of blood recirculating devices.", Annals of Biomedical Engineering, 38, (3), pp. 1236-56

V Govindarajan, H S Udaykumar, L H Herbertson, S Deutsch, Keefe B Manning and K B Chandran, 2010, "Two-dimensional FSI simulation of closing dynamics of a tilting disc mechanical heart valve.", Journal of Medical Devices, 4, (1), pp. 11001

N Yang, S Deutsch, Eric G Paterson and Keefe B Manning, 2010, "Hemodynamics of an end-to-side anastomotic graft for a pulsatile pediatric ventricular assist device.", Journal of Biomechanical Engineering, 132, (3), pp. 031009

N Yang, S Deutsch, Eric G Paterson and Keefe B Manning, 2010, "Comparative study of continuous and pulsatile left ventricular assist devices on the hemodynamics of a pediatric end-to-side anastomotic graft.", Cardiovascular Engineering and Technology, 1, (1)

B N Roszelle, S Deutsch and Keefe B Manning, 2010, "Flow visualization of three-dimensionality inside the 12 cc Penn State pulsatile pediatric ventricular assist device.", Annals of Biomedical Engineering, 38, (2), pp. 439-55

N Yang, S Deutsch, Eric G Paterson and Keefe B Manning, 2009, "Numerical study of blood flow at the end-to-side anastomosis of a left ventricular assist device for adult patients.", Journal of Biomechanical Engineering, 131, (11), pp. 111005

Richard B Medvitz, V Reddy, S Deutsch, Keefe B Manning and Eric G Paterson, 2009, "Validation of a CFD methodology for positive displacement LVAD analysis using PIV data.", Journal of Biomechanical Engineering, 131, (11), pp. 111009

V Govindarajan, H S Udaykumar, L H Herbertson, S Deutsch, Keefe B Manning and K B Chandran, 2009, "Impact of design parameters on bileaflet mechanical heart valve flow dynamics.", The Journal of Heart Valve Disease, 18, (5), pp. 535-45

G. Pantalos, Z. J. Wu, G. Giriharan, S. Patel, J. Rinaldi, S. Stewart, P. Hariharan, Q. Lu, M. Berman, B. Lukic, S. Deutsch, P. Cahalan, E. Leonard, Keefe B Manning, J. Antaki, D. Paden, R. Malinauskas, W. Smith, L. Mockros, T. Snyder, G. Johnson and T. Baldwin, 2009, "Use of computer and in vitro modeling techniques during the development of pediatric circulatory support devices", American Society of Artificial Internal Organs Journal, 55, (1)

G. Pantalos, Z. J. Wu, G. Giriharan, S. Patel, J. Rinaldi, S. Stewart, P. Hariharan, Q. Lu, M. Berman, B. Lukic, S. Deutsch, P. Cahalan, E. Leonard, Keefe B Manning, J. Antaki, D. Paden, R. Malinauskas, W. Smith, L. Mockros, T. Snyder, G. Johnson and T. Baldwin, 2009, "Use of computer and in vitro modeling techniques during the development of pediatric circulatory support devices", American Society of Artificial Internal Organs Journal , Erratum, 55, (3)

L H Herbertson, S Deutsch and Keefe B Manning, 2008, "Modifying a tilting disk mechanical heart valve design to improve closing dynamics.", Journal of Biomechanical Engineering, 130, (5), pp. 054503

B T Cooper, B N Roszelle, T C Long, S Deutsch and Keefe B Manning, 2008, "The 12 cc Penn State pulsatile pediatric ventricular assist device: fluid dynamics associated with valve selection.", Journal of Biomechanical Engineering, 130, (4), pp. 041019

Keefe B Manning, L H Herbertson, Arnold A Fontaine and S Deutsch, 2008, "A detailed fluid mechanics study of tilting disk mechanical heart valve closure and the implications to blood damage.", Journal of Biomechanical Engineering, 130, (4), pp. 041001

Keefe B Manning, B. D. Wivholm, N. Yang, A. A. Fontaine and S. Deutsch, 2008, "Flow behavior within the Penn State 12cc pulsatile pediatric ventricular assist device: An experimental study of the initial design", Artificial Organs, 32, pp. 442-452

B N Rozelle, B T Cooper, T C Long, S Deutsch and Keefe B Manning, 2008, "The 12 cc Penn State pulsatile pediatric ventricular assist device: flow field observations at a reduced beat rate with application to weaning.", ASAIO Journal (American Society for Artificial Internal Organs : 1992), 54, (3), pp. 325-31

Richard B Medvitz, J W Kreider, Keefe B Manning, Arnold A Fontaine, S Deutsch and Eric G Paterson, 2007, "Development and validation of a computational fluid dynamics methodology for simulation of pulsatile left ventricular assist devices.", ASAIO Journal (American Society for Artificial Internal Organs : 1992), 53, (2), pp. 122-31

L H Herbertson, V Reddy, Keefe B Manning, J P Welz, Arnold A Fontaine and S Deutsch, 2006, "Wavelet transforms in the analysis of mechanical heart valve cavitation.", Journal of Biomechanical Engineering, 128, (2), pp. 217-22

J W Kreider, Keefe B Manning, L A Oley, Arnold A Fontaine and S Deutsch, 2006, "The 50cc Penn State left ventricular assist device: a parametric study of valve orientation flow dynamics.", ASAIO Journal (American Society for Artificial Internal Organs : 1992), 52, (2), pp. 123-31

S. Deutsch, J. M. Tarbell, Keefe B Manning, G. Rosenberg and A. A. Fontaine, 2006, "Experimental Fluid Mechanics of Pulsatile Artificial Blood Pumps", Annual Review of Fluid Mechanics, 38, pp. 65-86

L H Herbertson, Keefe B Manning, V Reddy, Arnold A Fontaine, J M Tarbell and S Deutsch, 2005, "The effect of dissolved carbon dioxide on cavitation intensity in mechanical heart valves.", Journal of Heart Disease, 14, (6), pp. 835-42

Jennifer Long, Akif Undar, Keefe B Manning and S Deutsch, 2005, "Viscoelasticity of pediatric blood and its implications for the testing of a pulsatile pediatric blood pump.", ASAIO Journal (American Society for Artificial Internal Organs : 1992), 51, (5), pp. 563-6

K Sohn, Keefe B Manning, Arnold A Fontaine, J M Tarbell and S Deutsch, 2005, "Acoustic and visual characteristics of cavitation induced by mechanical heart valves.", The Journal of Heart Valve Disease, 14, (4), pp. 551-8

L A Oley, Keefe B Manning, Arnold A Fontaine and S Deutsch, 2005, "Off-design considerations of the 50cc Penn State Ventricular Assist Device.", Artificial Organs, 29, (5), pp. 378-86

Keefe B Manning, T M Przybysz, Arnold A Fontaine, J M Tarbell and S Deutsch, 2005, "Near field flow characteristics of the Bjork-Shiley Monostrut valve in a modified single shot valve chamber.", ASAIO Journal (American Society for Artificial Internal Organs : 1992), 51, (2), pp. 133-8

L. A. Oley, Keefe B Manning, A. A. Fontaine and S. Deutsch, 2005, "Off design considerations of the 50cc Penn State ventricular assist device", Artificial Organs, 29, pp. 378-386

P Hochareon, Keefe B Manning, Arnold A Fontaine, J M Tarbell and S Deutsch, 2004, "Correlation of in vivo clot deposition with the flow characteristics in the 50 cc penn state artificial heart: a preliminary study.", ASAIO journal (American Society for Artificial Internal Organs : 1992), 50, (6), pp. 537-42

P Hochareon, Keefe B Manning, Arnold A Fontaine, J M Tarbell and S Deutsch, 2004, "A fluid dynamic analysis of the 50 cc Penn State Artificial Heart under physiological operating conditions using particle image velocimetry.", Journal of Biomechanical Engineering, 126, (5), pp. 585-93

P Hochareon, Keefe B Manning, Arnold A Fontaine, J M Tarbell and S Deutsch, 2004, "Wall shear-rate estimation within the 50cc Penn State artificial heart using particle image velocimetry.", Journal of Biomechanical Engineering, 126, (4), pp. 430-7

P Hochareon, Keefe B Manning, Arnold A Fontaine, S Deutsch and J M Tarbell, 2003, "Diaphragm motion affects flow patterns in an artificial heart.", Artificial Organs, 27, (12), pp. 1102-9

P Johansen, Keefe B Manning, J M Tarbell, Arnold A Fontaine, S Deutsch and H Nygaard, 2003, "A new method for evaluation of cavitation near mechanical heart valves.", Journal of Biomechanical Engineering, 125, (5), pp. 663-70

Keefe B Manning, V Kini, Arnold A Fontaine, S Deutsch and J M Tarbell, 2003, "Regurgitant flow field characteristics of the St. Jude bileaflet mechanical heart valve under physiologic pulsatile flow using particle image velocimetry.", Artificial Organs, 27, (9), pp. 840-6

Keefe B Manning and G E Miller, 2002, "Flow through an outlet cannula of a rotary ventricular assist device.", Artificial Organs, 26, (8), pp. 714-23

Keefe B Manning and G E Miller, 1999, "Shaft/shaft-seal interface characteristics of a multiple disk centrifugal blood pump.", Artificial Organs, 23, (6), pp. 552-8

Bryan C Good, Scott D Simon, Keefe B Manning and Francesco Costanzo, , "Development of a Computational Model for Acute Ischemic Stroke Recanalization Through Cyclic Aspiration", Biomechanics and Modeling in Mechanobiology

• Fellow, American Institute for Medical and Biological Engineering, 2021

• Fellow, American Society of Mechanical Engineers, 2020

• Fellow, Biomedical Engineering Society, October 2023

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