Photo of Siyang Zheng

Siyang Zheng

Associate Professor


  • Biomedical Engineering
  • School of Electrical Engineering and Computer Science
  • Electrical Engineering

N238 Millennium Science Complex


Personal or Departmental Website

Research Areas:

BioMEMS and Nanotechnology





Parts of Book

  • Siyang Zheng, K. Shaikh and J. Xie, 2010, Fluid Control Pumps and Valves. Microflow Cytometer, Pan Stanford Publishing, Hackensack, NJ, USA
  • H. Lin, Siyang Zheng, M. Balic, R. J. Cote, Y.-C. Tai and R. H. Datar, 2009, Microfabricated Devices for Detection of Circulating Tumor Cells in Cancer Patient Blood Samples, Artech House, Norwood, MA, USA

Journal Articles

  • Gong Cheng, Xiao-Hui Han, Si-Jie Hao, Merisa Nisic and Siyang Zheng, 2018, "In situ caging of biomolecules in graphene hybrids for light modulated bioactivity", ACS Applied Materials & Interfaces, 10, (4), pp. 3361-3371
  • Yin-Ting Yeh, Zhong Lin, Siyang Zheng and Mauricio Terrones Maldonado, 2018, "A carbon nanotube integrated microfluidic device for blood plasma extraction", Scientific Reports, 8, (1), pp. 13623
  • Sijie Hao, Laura Ha, Gong Cheng, Yuan Wan, Yiqiu Xia, Donna M. Sosnoski, Andrea M Mastro and Siyang Zheng, 2018, "A Spontaneous 3D Bone-On-a-Chip for Bone Metastasis Study of Breast Cancer Cells", Small, 14, (12), pp. 1702787
  • Yuan Wan, Lixue Wang, Chuandong Zhu, Qin Zheng, Guoxiang Wang, Jinlong Tong, Yuan Fang, Yiqiu Xia, Gong Cheng, Xia He and Siyang Zheng, 2018, "Aptamer-conjugated extracellular nanovesicles for targeted drug delivery", Cancer Research, 78, (3), pp. 798-808
  • Yuan Wan, Mackenzie Maurer, Hong-Zhang He, Yi-Qiu Xia, Si-Jie Hao, Wen-Long Zhang, Nelson S. Yee and Siyang Zheng, 2018, "Enrichment of extracellular vesicles using lipid nanoprobes functionalized nanostructured silica", under review
  • Yin-Ting Yeh, Y. Tang, Zhenwu Lin, Kazunori Fujisawa, Y. Lei, Y. Zhou, C. Rotella, A. L. Elias, Siyang Zheng, Yingwei Mao, Zhiwen Liu, Huaguang Lu and Mauricio Terrones Maldonado, 2018, "Light-emitting transition metal dichalcogenide monolayers under cellular digestion", Advanced Materials, 30, (8), pp. 1703321
  • Wenjie Li, Z. Wang, S. Hao, Liyong Sun, M. Nisic, G. Cheng, C. Zhu, Y. Wan, L. Ha and Siyang Zheng, 2018, "Mitochondria-based aircraft carrier enhances in vivo imaging of carbon quantum dots and delivery of anticancer drug", Nanoscale, 10, (8), pp. 3744-3752
  • Yuan Wan, Biao Liu, Haozhi Lei, Biao Zhang, Yuheng Wang, Haitao Huang, Shaomu Chen, Yu Feng, Lin Zhu, Yuanyuan Gu, Qun Zhang, Haitao Ma and Siyang Zheng, 2018, "Nanoscale extracellular vesicle-derived DNA is superior to circulating cell free DNA for mutation detection in early-stage non-small cell lung cancer. (in press)", Annals of Oncology, 29, (12), pp. 2379-2383
  • Yiqiu Xia, Yuan Wan, Sijie Hao, Merisa Nisic, Ramdane A. Harouaka, Yizhu Chen, Xin Zou and Siyang Zheng, 2018, "Nucleus of circulating tumor cell determines its translocation through biomimetic microconstrictions and its physical enrichment by microfiltration", Small, 14, (44), pp. e1802899
  • Wen-Qing Li, Li-Ping Sun, Yiqiu Xia, Sijie Hao, Gong Cheng, Zhigang Wang, Yuan Wan, Chuandong Zhu, Hongzhang He and Siyang Zheng, 2018, "Preoccupation of Empty Carriers Decreases Endo-/Lysosome Escape and Reduces the Protein Delivery Efficiency of Mesoporous Silica Nanoparticles", ACS Applied Materials & Interfaces, 10, (6), pp. 5340-5347
  • Gong Cheng, Wenqing Li, Laura Ha, Xiaohui Han, Sijie Hao, Yuan Wan, Zhigang Wang, Fengping Dong, Xin Zou, Yingwei Mao and Siyang Zheng, 2018, "Self-assembly of extracellular vesicle-like metal–organic framework nanoparticles for protection and intracellular delivery of biofunctional proteins", Journal of the American Chemical Society, 140, (23), pp. 7282-7291
  • Si-Jie Hao, Yuan Wan, Yi-Qiu Xia, Xin Zou and Siyang Zheng, 2018, "Size-based separation methods of circulating tumor cells", Advanced Drug Delivery Reviews, 125, pp. 3-20
  • Yuan Wan, Gong Cheng, Xin Liu, Si-Jie Hao, Merisa Nisic, Chuan-Dong Zhu, Yi-Qiu Xia, Wen-Qing Li, Zhi-Gang Wang, Wen-Long Zhang, Shawn J Rice, Aswathy Sebastian, Istvan Albert, Chandra P Belani and Si-Yang Zheng, 2017, "Rapid isolation of extracellular vesicles via lipid nanoprobes", Nature Biomedical Engineering
  • Yiqiu Xia, Yi Tang, Xu Yu, Yuan Wan, Yizhu Chen, Huaguang Lu and Siyang Zheng, 2017, "Label-free virus capture and release by a microfluidic device integrated with porous silicon nanowire forest", Journal
  • Y. T. Yeh, R. A. Harouaka and Siyang Zheng, 2017, "Evaluating a novel dimensional reduction approach for mechanical fractionation of cells using a tandem flexible micro spring array (tFMSA)", Journal, 17, (4), pp. 691-701
  • Gong Cheng, Si-Jie Hao, Yuan Wan, Ding-Ying Shan, Jian Yang and Si-Yang Zheng, 2017, "Self-assembly of Smart Multifunctional Hybrid Compartments with Programmable Bioactivity", Journal
  • Xu Yu, Yiqiu Xia, Yi Tang, Wen-Long Zhang, Yin-Ting Yeh, Huaguang Lu and Si-Yang Zheng, 2017, "A Nanostructured Microfluidic Immunoassay Platform for Highly Sensitive Infectious Pathogen Detection", Small, 13, (24)
  • Ming-Da Zhou, Muhammad Akbar, Andrew J Myrick, Yiqiu Xia, Waleed J. Khan, Xiang Gao, Thomas C Baker and Si-Yang Zheng, 2017, "Chopper-modulated gas chromatography electroantennography enabled using high-temperature MEMS flow control device", MICROSYSTEMS & NANOENGINEERING, 3
  • Wen-Qing Li, Zhigang Wang, Sijie Hao, Hongzhang He, Yuan Wan, Chuandong Zhu, Li-Ping Sun, Gong Cheng and Si-Yang Zheng, 2017, "Mitochondria-Targeting Polydopamine Nanoparticles To Deliver Doxorubicin for Overcoming Drug Resistance", ACS APPLIED MATERIALS & INTERFACES, 9, (20), pp. 16794-16803
  • Jinshan Guo, Wei Wang, Jianqing Hu, Denghui Xie, Ethan Gerhard, Merisa Nisic, Dingying Shan, Guoying Qian, Siyang Zheng and Jian Yang, 2016, "Synthesis and characterization of anti-bacterial and anti-fungal citrate-based mussel-inspired bioadhesives", Biomaterials
  • Yin-Ting Yeh, Yi Tang, Aswathy Sebastian, Archi Dasgupta, Nestor Perea-Lopez, Istvan Albert, Huaguang Lu, Mauricio Terrones and Si-Yang Zheng, 2016, "Tunable and label-free virus enrichment for ultrasensitive virus detection using carbon nanotube arrays", Science Advances
  • Chenji Zhang, Gong Cheng, Perry Edwards, Ming-Da Zhou, Si-Yang Zheng and Zhiwen Liu, 2016, "G-Fresnel smartphone spectrometer", Lab on a Chip
  • E. M. Matthew, L. Zhou, Zifeng Yang, D. T. Dicker, S. L. Holder, B. Lim, R. Harouaka, Siyang Zheng, J. J. Drabick, N. E. Lamparella, C. I. Truica and W. S. El-Deiry, 2016, "A multiplexed marker-based algorithm for diagnosis of carcinoma of unknown primary using circulating tumor cells", 7, (4), pp. 3662-76
  • G. Cheng, Zhiren Wang, S. Denagamage and Siyang Zheng, 2016, "Graphene-Templated Synthesis of Magnetic Metal Organic Framework Nanocomposites for Selective Enrichment of Biomolecules", 8, (16), pp. 10234-42
  • Yanyuan Ma, S. Hao, Shuwen Wang, Y. Zhao, B. Lim, M. Lei, David J Spector, W. S. El-Deiry, Siyang Zheng and Jun Zhu, 2015, "A Combinatory Strategy for Detection of Live CTCs Using Microfiltration and a New Telomerase-Selective Adenovirus", Mol Cancer Ther, 14, (3), pp. 835-43
  • J. T. Kaifi, M. Kunkel, Arunangshu das, R. A. Harouaka, D. T. Dicker, G. Li, Jun Zhu, Gary A Clawson, Zifeng Yang, M. F. Reed, N. J. Gusani, E. T. Kimchi, K. F. Staveley-O’Carroll, Siyang Zheng and W. S. El-Deiry, 2015, "Circulating tumor cell isolation during resection of colorectal cancer lung and liver metastases: a prospective trial with different detection techniques", 16, (5), pp. 699-708
  • Y. Tang, Huaguang Lu, A. Sebastian, Y. T. Yeh, Craig A Praul, Istvan Albert and Siyang Zheng, 2015, "Genomic characterization of a turkey reovirus field strain by Next-Generation Sequencing", 32, pp. 313-21
  • X. Yu, Zhihua Zhang and Siyang Zheng, 2015, "Highly sensitive DNA detection using cascade amplification strategy based on hybridization chain reaction and enzyme-induced metallization", 66, (0), pp. 520-6
  • G. Cheng, S. J. Hao, X. Yu and Siyang Zheng, 2015, "Nanostructured microfluidic digestion system for rapid high-performance proteolysis", 15, (3), pp. 650-4
  • X. Yu, G. Cheng, M. D. Zhou and Siyang Zheng, 2015, "On-demand one-step synthesis of monodisperse functional polymeric microspheres with droplet microfluidics", 31, (13), pp. 3982-92
  • Ramdane Harouaka, Zhigang Kang, Si-Yang Zheng and Liang Cao, 2014, "Circulating tumor cells: Advances in isolation and analysis, and challenges for clinical applications", 141, (2), pp. 209-221
  • G. Cheng and Siyang Zheng, 2014, "Construction of a high-performance magnetic enzyme nanosystem for rapid tryptic digestion", 4, pp. 6947
  • R. A. Harouaka, M. D. Zhou, Y. T. Yeh, W. J. Khan, Arunangshu das, Xin Liu, C. C. Christ, D. T. Dicker, T. S. Baney, J. T. Kaifi, C. P. Belani, C. I. Truica, W. S. El-Deiry, J. P. Allerton and Siyang Zheng, 2014, "Flexible micro spring array device for high-throughput enrichment of viable circulating tumor cells", 60, (2), pp. 323-33
  • M. D. Zhou, S. Hao, A. J. Williams, R. A. Harouaka, B. Schrand, S. Rawal, Z. Ao, R. Brennaman, E. Gilboa, B. Lu, Shuwen Wang, Jun Zhu, R. Datar, R. Cote, Y. C. Tai and Siyang Zheng, 2014, "Separable Bilayer Microfiltration Device for Viable Label-free Enrichment of Circulating Tumour Cells", 4, pp. 7392
  • R. A. Harouaka, M. Nisic and Siyang Zheng, 2013, "Circulating tumor cell enrichment based on physical properties", 18, pp. 455-468
  • J.-N. Gallant, E. M. Matthew, H. Cheng, R. Harouaka*, N. E. Lamparella, M. Kunkel, Z. Yang, H. A. Harvey, L. V. Cream, S. M. Kumar, G. P. Robertson, Siyang Zheng, J. J. Drabick, C. I. Truica and W. S. El-Deiry, 2013, "Predicting therapy response in live tumor cells isolated with the flexible micro spring array device", 12, pp. 2132-2143
  • B. Ramaswamy*, Y. T. Yeh* and S.-Y. Zheng, 2013, "Microfluidic device and system for point-of-care blood coagulation measurement based on electrical impedance sensing", 180, pp. 21-27
  • Ramdane A. Harouaka, Merisa Nisic and Si-Yang Zheng, 2013, "Circulating Tumor Cell Enrichment Based on Physical Properties", Journal of Laboratory Automation, 18, (6), pp. 455 - 468
  • Bharath Ramaswamy, Yin-Ting Tim Yeh and Si-Yang Zheng, 2013, "Microfluidic device and system for point-of-care blood coagulation measurement based on electrical impedance sensing", Sensors and Actuators B: Chemical, 180, (0), pp. 21-27
  • Jean-Nicolas Gallant, Elizabeth M. Matthew, Hairong Cheng, Ramdane Harouaka, Nicholas E. Lamparella, Miriam Kunkel, Zhaohai Yang, Harold A. Harvey, Leah V. Cream, Suresh Kumar, Gavin P Robertson, Siyang Zheng, Joseph J. Drabick, Cristina I. Truica and Wafik S. El-Deiry, 2013, "Predicting therapy response in live tumor cells isolated with the flexible micro spring array device", Cell Cycle, 12, (13), pp. 2132-2143
  • M.-D. Zhou, C. Yang, Z. Liu, J. P. Cysyk and Siyang Zheng, 2012, "An implantable Fabry-Pérot pressure sensor fabricated on left ventricular assist device for heart failure", 14, pp. 235-245
  • Ming-Da Zhou, Chuan Yang, Zhiwen Liu, Joshua Peter Cysyk and Si-Yang Zheng, 2012, "An implantable Fabry-Pérot pressure sensor fabricated on left ventricular assist device for heart failure", Biomedical Microdevices, 14, (1), pp. 235-245
  • Gary A Clawson, Eric Kimchi, Susan D. Patrick, Ping Xin, Ramdane Harouaka, Siyang Zheng, Arthur Steven Berg, Todd Schell, Kevin F. Staveley-O’Carroll, Rogerio I. Neves, Paul J. Mosca and Diane Thiboutot, 2012, "Circulating Tumor Cells in Melanoma Patients", 7, (7), pp. e41052
  • Chuan Yang, Kebin Shi, Mingda Zhou, Siyang Zheng, Shizhuo Yin and Zhiwen Liu, 2012, "Z-microscopy for parallel axial imaging with micro mirror array", 101, (23), pp. 231111-5
  • Siyang Zheng, H. K. Lin, B. Lu, A. Williams, R. H. Datar, R. J. Cote and Y.-C. Tai, 2011, "3D microfilter device for viable circulating tumor cell (CTC) enrichment from blood", 13, pp. 203-213
  • H. K. Lin, Siyang Zheng, A. J. Williams, M. Balic, S. Groshen, H. I. Scher, M. Fleisher, W. Stadler, R. H. Datar, Y.-C. Tai and R. J. Cote, 2011, "Portable filter-based microdevice for detection and characterization of circulating tumor cells", 16, pp. 5011-5018
  • Henry Lin, Marija Balic, Siyang Zheng, Ram Datar and Richard J. Cote, 2011, "Disseminated and circulating tumor cells: Role in effective cancer management", 77, (1), pp. 1-11
  • B. Lu, Siyang Zheng, B. Q. Quach and Y.-C. Tai, 2010, "The autofluorescence study of parylene materials for µTAS applications", 10, (14), pp. 1826-1834
  • Siyang Zheng, J. C.-H. Lin, H. L. Kasdan and Y. C. Tai, 2008, "Leukocyte Counting and Differentiation from Undiluted Whole Blood Samples", 132, pp. 558-576
  • Siyang Zheng, M. Liu and Y. C. Tai, 2008, "Micro coulter counters with platinum black electroplated electrodes for human blood cell sensing", 10, (2), pp. 221-31
  • Siyang Zheng, Mandheerej S. Nandra, Chi-Yuan Shih, Wei Li and Yu-Chong Tai, 2008, "Resonance impedance sensing of human blood cells", 145–146, (0), pp. 29-36
  • Siyang Zheng, Hangsheng Lin, Jude Liu, M. Balic, R. Datar, R. J. Cote and Y. C. Tai, 2007, "Membrane microfilter device for selective capture, electrolysis and genomic analysis of human circulating tumor cells", 1162, (2), pp. 154-61

Research Projects

Honors and Awards


Service to Penn State:

Service to External Organizations:




The Department of Biomedical Engineering administers the undergraduate major in biomedical engineering, and is a part of the university-wide Intercollege Graduate Degree Program, offering both M.S. and Ph.D. degrees in Bioengineering. Our work combines traditional engineering principles with medicine and technology for the betterment of human health and society. 

Department of Biomedical Engineering

122 Chemical and Biomedical Engineering Building

The Pennsylvania State University

University Park, PA 16802-4400

Phone: 814-863-6614