Photo of Manish Kumar

Manish Kumar

Associate Professor


  • Chemical Engineering
  • Biomedical Engineering
  • Civil and Environmental Engineering

413 Chemical and Biomedical Engineering Building


Personal or Departmental Website

Research Areas:

Biotechnology and Synthetic Biology; Environmental Engineering; Separations and Transport

Interest Areas:

Membranes, Biomimetic membranes, membrane proteins, desalination, self assembly electron microscopy




  • B. Tech, Chemical Engineering, National Institute of Technology, Trichy, 1998
  • MS, Environmental Engineering, University of Illinois at Urbana Champaign, 2000
  • Ph D, Environmental Engineering, University of Illinois at Urbana Champaign, 2010


Book, Chapters

  • Manish Kumar, Michelle M Payne, Sean K Poust and Julie L Zilles, 2012, Polymer-based biomimetic membranes for desalination, Springer Netherlands, pp. 43–62

Parts of Book

  • Manish Kumar, Y. Shen and P. Saboe, 2013, Biological and biomimetic membranes, Wiley Interscience
  • Manish Kumar, S. Adham and W. Pearce, 2007, An Integrated Approach to Pretreatment Evaluation for Seawater Reverse Osmosis using Bench and Pilot Scale Testing, AWWA, Denver, CO
  • Manish Kumar, S. Adham and W. Pearce, 2006, Evaluation of New Generation RO membranes for Brackish Groundwater Desalination

Journal Articles

  • Jun-Seob Kim, Allen B Schantz, Sooyeon Song, Manish Kumar and Thomas Wood, 2018, "GhoT of the GhoT/GhoS toxin/antitoxin system damages lipid membranes by forming transient pores", Biochemical and Biophysical Research Communications
  • Hasin Feroz, HyeYoung Kwon, Jing Peng, Hyeonji Oh, Bryan Ferlez, Carol S Baker, John H Golbeck, Guillermo C Bazan, Andrew Zydney and Manish Kumar, 2018, "Improving extraction and post-purification concentration of membrane proteins", Analyst
  • Patrick O Saboe, Emelia Conte, Megan Farell, Guillermo C Bazan and Manish Kumar, 2017, "Biomimetic and bioinspired approaches for wiring enzymes to electrode interfaces", Energy & Environmental Science, 10, (1), pp. 14-42
  • Hasin Feroz, Michelle Bai, HyeYoung Kwon, John Brezovec, Jing Peng and Manish Kumar, 2017, "Can Fibrous Mats Outperform Current Ultrafiltration and Microfiltration Membranes?", Industrial & Engineering Chemistry Research, 56, (37), pp. 10438-10447
  • Boya Xiong, Zachary Miller, Selina Roman-White, Travis Tasker, Benjamin Farina, Bethany Piechowicz, William D Burgos, Prachi Joshi, Liang Zhu, Christopher Gorski, Andrew Zydney and Manish Kumar, 2017, "Chemical Degradation of Polyacrylamide during Hydraulic Fracturing", Environmental science & technology, 52, (1), pp. 327-336
  • Malgorzata Kowalik, Allen B Schantz, Abdullah Naqi, Yuexiao Shen, Ian Sines, Janna K Maranas and Manish Kumar, 2017, "Chemically specific coarse-grained models to investigate the structure of biomimetic membranes", RSC Advances, 7, (86), pp. 54756-54771
  • DJ Follmer, EW Gomez, Sarah E Zappe and Manish Kumar, 2017, "Evaluation of a Research Experiences for Undergraduates Program in ChE indicates benefit from a collaborative model", Chemical Engineering Education, 51, (3), pp. 145-150
  • Tingwei Ren, Mustafa Erbakan, Yuexiao Shen, Eduardo Barbieri, Patrick Saboe, Hasin Feroz, Hengjing Yan, Samantha McCuskey, Joseph F Hall, Schantz and A Benjamin, 2017, "Membrane Protein Insertion into and Compatibility with Biomimetic Membranes", Advanced Biosystems, (10.1002/adbi.201700053)
  • Boya Xiong, Bethany Piechowicz, Ziyuhan Wang, Rose Marinaro, Emma Clement, Taylor Carlin, Adam Uliana, Manish Kumar and Stephanie B Velegol, 2017, "Moringa oleifera f-sand Filters for Sustainable Water Purification", Environmental Science & Technology Letters, 5, (1), pp. 38-42
  • Allen Schantz, Patrick Saboe, Ian Sines, Hee-Young Lee, Kyle Jeffrey Magnuson Bishop, Janna K Maranas, Paul Butler and Manish Kumar, 2017, "PEE–PEO Block Copolymer Exchange Rate between Mixed Micelles Is Detergent and Temperature Activated", Macromolecules, (10.1021/acs.macromol.6b01973)
  • Rajarshi Guha, Boya Xiong, Michael Geitner, Tevin Moore, Thomas Wood, Darrell Velegol and Manish Kumar, 2017, "Reactive micromixing eliminates fouling and concentration polarization in reverse osmosis membranes", Journal of Membrane Science, 542, pp. 8-17
  • Patrick O Saboe, Chiara Rapisarda, Shreyas Kaptan, Yu-Shan Hsiao, Samantha R Summers, R De Zorzi, Danijela Dukovski, Jiaheng Yu, Bert L de Groot and Manish Kumar, 2017, "Role of Pore-Lining Residues in Defining the Rate of Water Conduction by Aquaporin-0", Biophysical Journal, 112, (5), pp. 953-965
  • D.J. Follmer, S.E. Zappe, E.W. Gomez and Manish Kumar, 2017, "Student outcomes from undergraduate research programs: comparing models of research experiences for undergraduates (REUs)", SPUR: Scholarship and Practice of Undergraduate Research, 1, (1), pp. 20-27
  • Sung Hyun Cho, Pallinti Purushotham, Chao Fang, Cassandra Maranas, Sara M Díaz-Moreno, Vincent Bulone, Jochen Zimmer, Manish Kumar and B. Tracy Nixon, 2017, "Synthesis and self-assembly of cellulose microfibrils from reconstituted cellulose synthase", Plant physiology, pp. pp. 00619.2017
  • Y Chen, B Stemple, Manish Kumar and N Wei, 2016, "Cell surface display fungal laccase as a renewable biocatalyst for degradation of persistent micropollutants", Environmental Science and Technology
  • H Feroz, C Vanderwelden, B Ikwuagwu, B Ferlez, CS Baker, DJ Lugar, M Grzelakowski, JH Golbeck, Andrew Zydney and Manish Kumar, 2016, "Concentrating membrane proteins using ultrafiltration without concentrating detergents", Biotechnology and Bioengineering
  • P O Saboe, E Conte, S Chan, H Feroz, B Ferlez, M Farell, M F Poyton, I T Sines, H Yan, G Bazan, J H Golbeck and Manish Kumar, 2016, "Biomimetic wiring and stabilization of photosynthetic membrane proteins with block copolymer interfaces", Journal of Materials Chemistry A, (4(40)), pp. 15457-15463
  • P Purushotham, S H Cho, S M Diaz-Moreno, Manish Kumar, B T Nixon, V Bulone and J Zimmer, 2016, "A single plant cellulose synthase isoform is sufficient for cellulose microfibril formation in vitro", Proceedings of the National Academy of Sciences
  • J Du, V Vepachedu, S H Cho, Manish Kumar and B T Nixon, 2016, "Structure of the cellulose synthase complex of Gluconacetobacter hansenii at 23.4 Å resolution", PLOS One, 1.5, (e0155886)
  • Darrell Velegol, A Garg, R Guha, A Kar and Manish Kumar, 2016, "Origins of Concentration Gradients for Diffusiophoresis", Soft Matter, (2.21), pp. 4686-4703
  • E Licsandru, I Kocsis, Y Shen, S Murail, Y M Legrand, A van der Lee, D Tsai, M Baaden, Manish Kumar and M Barboiu, 2016, "Salt-excluding artificial water channels exhibiting enhanced dipolar water and proton translocation", Journal of the American Chemical Society, (138(16)), pp. 5403-5409
  • T L Wood, R Guha, M Geitner, Manish Kumar and T K Wood, 2016, "Living biofouling-resistant membranes as a model for the beneficial use of engineered biofilms", Proceedings of the National Academy of Sciences, (113.20), pp. E2802-E2811
  • B Xiong, Andrew Zydney and Manish Kumar, 2016, "Fouling of microfiltration membranes by flowback and produced waters from the Marcellus shale gas play", Water Research, pp. 162-170
  • Harrison Cassady, Emily Cimino, Manish Kumar and Michael A Hickner, 2016, "Specific ion effects on the permselectivity of sulfonated poly (ether sulfone) cation exchange membranes", Journal of Membrane Science, (508), pp. 146-152
  • Manish Kumar, Yue-xiao Shen and T Culp, 2016, "The Sustainability of Desalination"
  • Y Shen, W Si, M Erbakan, K Decker, R Zorzi, P Saboe, Y Kang, S Maid, P Butler, T Walz, A Aksimentiev, J Hou and Manish Kumar, 2015, "Highly Permeable artificial water channels that self-assemble into two-dimensional arrays", Proceedings of the National Academy of Sciences, 112, (32), pp. 9810-9815
  • S H Cho, J Du, I Sines, V G Poosarla, K Kafle, Y B Park, S H Kim, A W Roberts, Manish Kumar and B T Nixon, 2015, "In vitro synthesis of cellulose microfibrils by membrane protein from protoplasts of the non-vascular plant Physcomitrella patens", Biochemical Journal, 470, (2), pp. 195-205
  • M Erbakan, B Curtis, B T Nixon, Manish Kumar and Wayne R Curtis, 2015, "Advancing Rhodobacter sphaeroides as a platform for expression of functional membrane proteins", Protein Expression and Purification, 115, pp. 109-117
  • R Guha, X Shang, Andrew Zydney, Darrell Velegol and Manish Kumar, 2015, "Diffusiophoresis Contributes Significantly to Colloidal Fouling in Low Salinity Reverse Osmosis Systems", Journal of Membrane Science, 479, pp. 67-76
  • B Xiong, T Richard and Manish Kumar, 2015, "Integrated Acidogenic Digestion and Carboxylic Acid Separation by Nanofiltration Membranes for the Lignocellulosic Carboxylate Platform", Journal of Membrane Science, 489, pp. 275-283
  • Mariusz Grzelakowski, Meron F Cherenet, Yue-xiao Shen and Manish Kumar, 2015, "A framework for accurate evaluation of the promise of aquaporin based biomimetic membranes", Journal of Membrane Science, 479, pp. 223-231
  • K. Shebek, A. B. Schantz, S. Velegol and Manish Kumar, 2015, "The flocculating cationic polypeptide from Moringa oleifera seeds damages bacterial cell membranes by causing membrane fusion", Langmuir, 31, pp. 4496-4502
  • Steven S Klara, Patrick O Saboe, Ian T Sines, Mahnoush Babaei, Po-Lin Chiu, Rita DeZorzi, Kaushik Dayal, Thomas Walz, Manish Kumar and Meagan S Mauter, 2015, "Magnetically Directed Two-Dimensional Crystallization of OmpF Membrane Proteins in Block Copolymers", Journal of the American Chemical Society, (138(1)), pp. 28-31
  • P. Saboe, C. Lubner, N. McCool, N. Vargas-Barbosa, H. Yan, S. Chan, B. Ferlez, G. C. Bazan, J. Golbeck and Manish Kumar, 2014, "Two-dimensional Protein Crystals for Solar Energy Conversion", Advanced Materials, 26, (41), pp. 7064-7069
  • Y. Shen, P. Saboe, I. Sines, M. Erbakan and Manish Kumar, 2014, "Biomimetic membranes: A review", J Membr. Sci., 454, pp. 359-381
  • A. Kar, R. Guha, N. S. Dani, Darrell Velegol and Manish Kumar, 2014, "Particle deposition on Microporous Membranes can be Enhanced or Reduced by Salt Gradients", Langmuir, 30, pp. 793-799
  • Y. Kaufman, S. Grinberg, C. Linder, E. Heldman, J. Gilron, Y. Shen, Manish Kumar, R. Lammertink and V. Freger, 2014, "Towards Supported Bolaamphiphile Membranes for Water Filtration: Roles of Lipid Substrate", Journal of Membrane Science, 457, pp. 50-61
  • Mustafa Erbakan, Yue-xiao Shen, Mariusz Grzelakowski, Peter J Butler, Manish Kumar and Wayne R Curtis, 2014, "Molecular Cloning, Overexpression and Characterization of a Novel Water Channel Protein from Rhodobacter sphaeroides", PloS one, 9, (1), pp. e86830
  • Justin M Hutchison, Sean K Poust, Manish Kumar, Donald M Cropek, Irene E MacAllister, Clint M Arnett and Julie L Zilles, 2013, "Perchlorate Reduction Using Free and Encapsulated Azospira oryzae Enzymes", Environmental science & technology, 47, (17), pp. 9934–9941
  • Manish Kumar, J. Habel, Y. Shen, W. Meier and T. Walz, 2012, "High-density reconstitution of functional membrane proteins into vesicular and planar block copolymer membranes", Journal of the American Chemical Society, 134, pp. 18631-18637
  • Fabian Itel, Samer Al-Samir, Fredrik Öberg, Mohamed Chami, Manish Kumar, Claudiu T Supuran, Peter MT Deen, Wolfgang Meier, Kristina Hedfalk and Gerolf Gros, 2012, "CO2 permeability of cell membranes is regulated by membrane cholesterol and protein gas channels", The FASEB Journal, 26, (12), pp. 5182–5191
  • Sania Ibragimova, Michelle Marincel, Manish Kumar, Helen Nguyen, Claus Helix-Nielsen and Julie Zilles, 2011, "Establishing Conditions for Compartmentalized and Lamellar Biomimetic Supported Biomimetic Membranes", Biophysical Journal, 100, (3), pp. 499a
  • David A Ladner, Arun Subramani, Manish Kumar, Samer S Adham and Mark M Clark, 2010, "Bench-scale evaluation of seawater desalination by reverse osmosis", Desalination, 250, (2), pp. 490–499
  • Manish Kumar, 2010, "Biomimetic membranes as new materials for applications in environmental engineering and biology"
  • Mariusz Grzelakowski, Ozana Onaca, Per Rigler, Manish Kumar and Wolfgang Meier, 2009, "Immobilized Protein–Polymer Nanoreactors", Small, 5, (22), pp. 2545–2548
  • Mohammad Badruzzaman, Joan Oppenheimer, Samer Adham and Manish Kumar, 2009, "Innovative beneficial reuse of reverse osmosis concentrate using bipolar membrane electrodialysis and electrochlorination processes", Journal of Membrane Science, 326, (2), pp. 392–399
  • Manish Kumar, Mohammad Badruzzaman, Samer Adham and Joan Oppenheimer, 2007, "Beneficial phosphate recovery from reverse osmosis (RO) concentrate of an integrated membrane system using polymeric ligand exchanger (PLE)", Water research, 41, (10), pp. 2211–2219
  • Samer Adham, Joan Oppenheimer, Manish Kumar, Larry Webb and Richard Kottenstette, 2007, "Beneficial Reuse of RO Concentrate: Innovative Approaches", 2007 Membrane Technology Conference & Exposition Proceedings
  • Manish Kumar, Samer Adham, James DeCarolis and William Pearce, 2007, "Comparative seawater RO pretreatment evaluation using bench-and pilot-scale testing", Journal (American Water Works Association), pp. 168–178
  • Li Liu, Samer Adham, Joan Oppenheimer and Manish Kumar, 2007, "Dewatering reverse osmosis concentrate using forward osmosis", 2007 Membrane Technology Conference & Exposition Proceedings
  • Manish Kumar, Mariusz Grzelakowski, Julie Zilles, Mark Clark and Wolfgang Meier, 2007, "Highly permeable polymeric membranes based on the incorporation of the functional water channel protein Aquaporin Z", Proceedings of the National Academy of Sciences, 104, (52), pp. 20719
  • Manish Kumar, Samer Adham and James DeCarolis, 2007, "Reverse osmosis integrity monitoring", Desalination, 214, (1), pp. 138–149
  • Manish Kumar, S. Adham and W. Pearce, 2006, "Development of a protocol for evaluation of new generation RO membranes", Journal of the American Water Works Association, 98, (4), pp. 122-132
  • Manish Kumar, Samer Adham and William Pearce, 2006, "Developing a protocol to evaluate new-generation membranes for desalinating brackish groundwater", Journal (American Water Works Association), pp. 122–132
  • Samer Adham, Joan Oppenheimer and Manish Kumar, 2006, "Innovative Approaches to RO Concentrate Management: Beneficial Reuse and Concentrate Minimization", Proceedings of the Water Environment Federation, 2006, (8), pp. 4334–4344
  • Manish Kumar, Samer S Adham and William R Pearce, 2006, "Investigation of seawater reverse osmosis fouling and its relationship to pretreatment type", Environmental science & technology, 40, (6), pp. 2037–2044
  • J. DeCarolis, Manish Kumar, S. Adham, W. Pearce and L. Wasserman, 2005, "Double Filtered for Freshness: An Integrated membrane System could expand water reuse options without excessive maintenance", Water Environment and Technology, pp. 41-47
  • S Adham, A Burbano, K Chiu and Manish Kumar, 2005, "Development of a NF/RO Knowledgebase, California Energy Commission", Public Interest Energy Research Program Report
  • James DeCarolis, Samer Adham, Manish Kumar, Bill Pearce and Larry Wasserman, 2005, "Integrity and performance evaluation of new generation desalting membranes during municipal wastewater reclamation", Proceedings of the Water Environment Federation, 2005, (12), pp. 3518–3529
  • S Adham, Manish Kumar and WH Pearce, 2005, "Model developed for brackish and reclaimed water", Desalination & Water Reuse, 15, (3), pp. 38–46
  • Manish Kumar, Samer Adham and William H Pearce, 2004, "Development of a Cost Model for Brackish and Reclaimed Water Membrane Desalination Costs", 2004 AWWA Annual Conference Proceedings
  • Samer Adham, Manish Kumar and William H Pearce, 2004, "Development of a model for brackish and reclaimed water membrane desalination costs", Proceedings of the International Conference on Desalination Costing, Limassol, Cyprus
  • Manish Kumar, James DeCarolis, Samer Adham, Larry Wasserman, Steve Lagos and William H Pearce, 2004, "Integrated membrane systems for wastewater reuse", Proceedings of the Water Environment Federation, 2004, (11), pp. 111–132
  • W Pearce, Manish Kumar and S Adham, 2003, "Evaluation of new generation low pressure brackish water reverse osmosis membranes", 2003 AWWA Annual Conference, pp. 2003

Conference Proceedings

  • M Escotet, Mustafa Erbakan, Manish Kumar and WR Curtis, 2013, "Use of Fluorescent Protein Fusions to Optimize Membrane Protein Expression in Anaerobic Photoheterotrophic Rhodobacter", AICHE conference
  • Manish Kumar, Wolfgang Meier and Julie Zilles, 2011, "Aquaporin based triblock copolymer membranes for water purification", Polymer Preprints, 52, (2), pp. 1060
  • JF De Carolis, P Gagliardo, Manish Kumar and S Adham, 2002, "Integration of low pressure membranes into an existing conventional water treatment facility", 223, pp. U513–U513

Technical Reports

  • Elizabeth M Dees, David Roger Moore, Li Li and Manish Kumar, 2017, "Model-Based Extracted Water Desalination System for Carbon Sequestration"


  • DJ Follmer, SE Zappe, Esther Gomez and Manish Kumar, 2016, "Student outcomes from undergraduate research programs: Comparing research experiences for undergraduates models", Council on undergraduate Research Quarterly


  • Manish Kumar, 2010, "Biomimetic membranes as new materials for applications in environmental engineering and biology"

Research Projects

Honors and Awards


Service to Penn State:

Service to External Organizations:




The Department of Biomedical Engineering administers the undergraduate major in biomedical engineering, and is a part of the university-wide Intercollege Graduate Degree Program, offering both M.S. and Ph.D. degrees in Bioengineering. Our work combines traditional engineering principles with medicine and technology for the betterment of human health and society. 

Department of Biomedical Engineering

122 Chemical and Biomedical Engineering Building

The Pennsylvania State University

University Park, PA 16802-4400

Phone: 814-863-6614