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Fellow of Royal Society of Chemistry

Dr. Wong is admitted as a Fellow of the Royal Society of Chemistry. FRSC status applies to individuals who have made an outstanding contribution to the advancement of the chemical sciences.  This is the third fellow honor Dr. Wong received, in addition to the SLAS and AIMBE recently.


Gates Foundation Grand Challenges

SBL awarded by the Gates Foundation Grand Challenge program. In this project, we will perform high-throughput screening for novel contraceptive agents using microfluidics. This project is a collaboration with Prof. Francisco Diaz in the Department of Animal Science. Congrats!


Best Poster Award in American Urological Association

Yuan Xiao and Yi Li won the "Best of Session Poster" award at the 2016 American Urological Association (AUA) Annual Convention in San Diego, CA.  May 2016


CM Ho Best Paper Award in Micro/Nano Fluidics

Luyi's work on "Long-Range Electrokinetic Fluid Motion for Rapid Pathogen Identification and Antimicrobial Susceptibility Testing" received the CM HO Best Paper Award in Micro/Nano Fluidics in the IEEE NEMS 2016 conference.  April 2016


SBL has moved to Penn State!

SBL is now a part of the Pennsylvania State University.  Dr. Wong joined Penn State through the Dean’s Frontier Faculty search at the College of Engineering.  Dr. Wong is a Professor in Biomedical Engineering, Mechanical Engineering and Surgery in the College of Medicine.  


Reza’s work is published in Nature Communications

Reza's work on the regulation of leader cell formation via Notch1-Dll4 signaling is accepted to Nature Communications. In this work, Reza, along with Sun Jian and Shue, demonstrated the formation of leader cell is dynamically regulated by intercellular stress and Notch1-Dll4 lateral inhibition. Great job everyone!   


Dr. Wong is a keynote speaker in Optofluidics 2015

Dr. Wong will be a keynote speaker in Optofluidics 2015, Taipei. The aim of Optofluidics2015 conference is to provide a forum to promote scientific exchange and to foster closer networks and collaborative ties between leading international optics and micro/nanofluidics researchers across various disciplines.


Reza and Shue’s work is selected as a JALA10 2015

Reza and Shue's single cell biosensor is selected as one of the JALA10- a top 10 technological breakthrough innovation in 2015. Reza and Shue demonstrate single-cell gene expression analysis in the native tissue environment using a gold nanorod-locked nucleic acid probe (GNR-LNA). The technology opens new opportunities in studying tissue morphogenesis and elucidating cancer heterogeneity in native tumor microenvironments. Great job, congratulations everyone!



News archive




Systematic Bioengineering Laboratory

The systematic bioengineering laboratory at Penn State University develops advanced biomanufacturing strategies for translational applications, such as mechanoregulation of collective cell migration in tissue regeneration and cancer metastasis, as well as molecular and microfluidic systems for clinical diagnostics. 




Featured Publications

R. Riahi, J. Sun, S. Wang, M. Long, D. D. Zhang, and P. K. Wong, “Notch1-Dll4 signaling and mechanical force regulate leader cell formation during collective cell migration” Nature Communications 6, 6556, 2015. Link


Z. Dean, R. Riahi, P. K. Wong, “Spatiotemporal dynamics of microRNA during epithelial collective cell migration” Biomaterials 37, 156-163, 2015. Link


R. Riahi, S. Wang, M. Long, N. Li, P.-Y. Chiou, D. D. Zhang, and P. K. Wong, “Mapping Photothermally Induced Gene Expression in Living Cells and Tissues by Nanorod-Locked Nucleic Acid Complexes” ACS Nano 8, 3597-3605, 2014.  Link


T. Liu, M. L. Y. Sin, J. D. Pyne, V. Gau, J. C. Liao, and P. K. Wong, “Electrokinetic Stringency Control in Self-Assembled Monolayer-based Biosensors for Multiplex Urinary Tract Infection Diagnosis”, Nanomedicine: Nanotechnology, Biology, and Medicine 10, 159-166, 2014. Link


Y. Lu, J. Gao, D. D. Zhang, V. Gau, J. C. Liao, and P. K. Wong, “Single cell antimicrobial susceptibility testing by confined microchannels and electrokinetic loading”, Analytical Chemistry 85, 3971-3976, 2013. Link


M. L. Y. Sin, T. Liu, J. D. Pyne, V. Gau, J. C. Liao, and P. K. Wong, “In situ electrokinetic enhancement for self-assembled monolayer based electrochemical biosensing”, Analytical Chemistry 84, 2702-2707, 2012. Link


M. Junkin, S. L. Leung, S. Whitman, C. C. Gregorio, and P. K. Wong, "Cellular Self-Organization via Autocatalytic Alignment Feedback", Journal of Cell Science 124, 4213-4220, 2011.  Link


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