Welcome to the Transformative Biomaterials and Biotechnology Lab (TBBL) at The Penn State University. Our research interests are to investigate a methodology for functional biomaterial development and use biomaterials as a tool to solve unmet clinical problems.

Currently, our research projects include: 1) Methodology for new biomaterial development; 2) soft and hard tissue engineering; 3) cancer drug delivery and imaging; 4) stem cell/biomaterial interactions; 5) micro-/nano-medical device fabrication; 6) biosensing.


Upcoming Events

Center for Regenerative Engineering and Translational Ecosystem Symposium

Save the date! The Symposium on Regenerative Engineering and Translational Ecosystem will take place on October 7, 2022 at the Centre Hills Country Club: 153 Country Club Rd, State College, PA 16801.





Congratulation to Yuki Yoshda on receiving Barry Goldwater Scholarship, the most prestigious undergraduate scholarship in natural science, mathematics, and engineering in America.


Undergraduate student, Yuki Yoshida published a first-author journal paper in Engineered Regeneration (https://doi.org/10.1016/j.engreg.2023.03.008)


Congratulation to Mariana Yasmin De Moura Lira Claudino and Emily Savidge for being selected as a member of Equity Scholars Program - a scholarship program to fund student participation in undergraduate research.


Dr. Lance Lian published in Cell Reports Methods on new gene editing tools to improve stem cell editing efficiency.



Congratulation to "Bioactive Materials" journal, the newly released 2021 Impact Factor is 16.874.


In collaboration with Dr. April Armstrong, Chair of the Department of Orthopedics and Rehabilitation, Dr. Yang received a COE Multidisciplinary Seed Grant to work on the next generation of citrate-based biomaterials for bone regeneration.



Dr. Yang received a R01 grant from NINDS to work on epigenetic nerve guidance conduits for peripheral nerve regeneration.

PSU News (08/16/22)


Dr. Yang teamed with Prof. Kytai Nguyen at UT Arlington and Prof. Ralph Mason at UT Southwestern to receive a R01 grant from NHLBI and to work on therapeutic nanoparticles to stimulate angiogenesis for the treatment of peripheral arterial disease.

PSU COE News (08/12/22)


Dr. Yang was elected a Full Member of Sigma Xi, the Scientific Research Honor Society.


Congratulation to the former PhD student, Gloria kim on starting her new job as an Assistant Professor at Mayo Clinic - Scottsdale.


Dr. Yang joined the editorial board of Science Advances as an Associate Editor.


Dr. Yang was named 2021 AAAS Fellow.
; PSU News


Acuitive Technologies Granted FDA 510(k) clearance for CITREFIX Knotless Suture Anchor

Acuitive News


Citrate-based biomaterials join a handful of biodegradable synthetic polymers used in FDA approved implantable medical devices: CITRELOCK Tendon Interference Screw System.

PSU News; Acuitive News


Congratulations to Dr. Yang for being elected to the Fellow of Biomedical Engineering Society.

PSU Engineering News.


Congratulations to former PhD student, Gloria Kim, who recently received a two-year postdoc fellowship totaling $159,807 from The Brody Family Medical Trust Fellowship in Incurable Diseases, awarded by The Philadelphia Foundation. Kim's proposal was titled "Evaluation of Splice Variants as Targets of Cancer Immunotherapy." Kim received her doctoral degree in bioengineering in 2017 and is currently a postdoctoral fellow at the University of Pennsylvania School of Medicine.


Breaking News: The first Impact Factor of Bioactive Materials was released today. The journal achieved an amazing impact factor of 8.724. It ranks the 2nd out of 38 journals in Materials Science, Biomaterials category and the 5th out of 87 journals in Engineering, Biomedical category. Many thanks to all editorial board members, reviewers, and contributing authors.


Congratulation to Dr. Gloria Kim and the team for the paper regarding CAR-T cell-mediated drug delivery for bran cancer treatment accepted by Bioactive Materials.


Congratulation to Dr. Jinshan Guo for his paper regarding "Citrate-based tannin-bridged bone composites for lumbar fusion" accepted by Advanced Functional Materials.


Congratulation to Sarah Knappman for winning a research scholarship from Society for Women Engineers (SWE) to support her research in Fall 2019.


Congratulation to PhD student, Chuying Ma for winning the Harold K. Schilling Dean's Graduate Scholarship. This scholarship recognizes Chuying's outstanding research on stem cells and orthopedic biomaterials.


Congratulation to Sarah Knappman, an undergraduate researcher in Yang lab, to receive David and Shirley Wormley Scholarship.


Dr. Yang was elected to National Academy of Inventors Fellow (NAI Fellow). NAI Press Release. PSU News


Congratulation to Chuying for her metabonegeneic citrate biomaterial paper accepted by PNAS. (News Link)


Dr. Yang was selected to receive Penn State Engineering Alumni Society (PSEAS) Outstanding Research Award.


TBBL welcomes Dr. Su Yan joining our research team.


Congratulation to Sarah Knappman and Yu-Chi Huang for winning 2018 Fall College of Engineering Research Initiative (CERI) scholarship.


TBBL celebrates the graduation of Dingying and Jimin. Congratulation to Dr. Dingying Shan and Dr. Jimin Peter Kim.


Congratulation, Dingying's paper regarding dual-imaging enabled biodegradable electroactive polymers was accepted by "Advanced Functional Materials".


Dr. Yang received a R01 grant from NIH/NIAMS to study citrate metabonegenesis regulation for new orthopedic biomaterial design.


Adv Mater 2014 (click polymer)
Adv Mater 2014 (BPLP-PLA)

PNAS 2009 (BPLP)
ACS Nano2014 (In situ endothelium repair)

Chemical Science 2017 (Fluorescent sensor for cystic fibrosis diagnosis)

Acta Biomaterialia
2017 (Complete story of citrate fluorescence mechanism)

Advanced Functional Materials 2018 (Dual imaging enabled multifunctional elastomers)
Small 2017 (Immune cell-mediated drug delivery)

PNAS 2018 (Citrate Metabonegenic Regulation and Bone Regeneration)

Advanced Science 2019

Adv. Funct. Mater 2020

Small 2022 (Biodegradable Osteopromotive Putty)


Positions Available

Postdoctoal fellow position (Please send your CV to Dr Jian Yang via email: jxy30@psu.edu to inquire the availability of positions.

PhD candidates: We are always seeking highly self-motivated and intelligent PhD students to work on biomaterials, stem cells, and tissue engineering projects. Students who have a strong background in any of the following disciplines: bioengineering, chemical engineering, material science engineering, chemistry, biology are all welcome to apply.

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