Sri-Rajasekhar (Raj) Kothapalli

Label-free Vascular Imaging using Miniaturized Photoaocustic Microscopy

Overview: Vascular diseases are becoming epidemic with increase in aging population, obesity, and type II diabetes. Some common vascular diseases are stroke, vascular malformation, peripheral artery disease (PAD), hemangioma, deep vein thrombosis (DVT), and chronic venous insufficiency (CVI). They affect adults, children and even newborn. Recently, photoacoustic imaging has emerged as the only label-free vascular imaging technique capable of mapping the functional and molecular information of blood vessels with high spatial (~ sub-micron) and temporal resolution (>10 KHz).

Proposed work: In Dr.Kothapalli’s lab the prospective student will design, fabricate and validate a low cost, miniaturized and portable photoacoustic microscope for mapping the vasculature of small animals (e.g., mice). He will integrate lasers and ultrasonic elements to develop a photoacoustic sensor head that will be programmed to map the vasculature. The student will then validate the developed microscope on vascular phantoms as well as mice models of cardiovascular disease (e.g., stroke). A student working in this project should have some experience (and strong motivation to further develop skills) in instrumentation, programming (MatLab and LabView), signal processing, mathematics and engineering.

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  • Application deadline is January 22, 2018

Contact Information

  • Jenna Sieber
    Graduate Program Assistant
    REU Administrative Assistant
    205 Hallowell Building


The Department of Biomedical Engineering administers the undergraduate major in biomedical engineering, and is a part of the university-wide Intercollege Graduate Degree Program, offering both M.S. and Ph.D. degrees in Bioengineering. Our work combines traditional engineering principles with medicine and technology for the betterment of human health and society. 

Department of Biomedical Engineering

205 Hallowell Building

The Pennsylvania State University

University Park, PA 16802-4400

Phone: 814-863-6614