Nanyin Zhang

Investigating the influence of physiological fluctuation on resting-state fMRI (Translational Neuroimaging and Systems Neuroscience Lab)

Project Description: The quantification of resting-state functional connectivity (RSFC) measured by resting-state functional magnetic resonance imaging (rsfMRI) is vulnerable to heart rate changes. To mitigate this physiological confounder, a common practice is to regress out the heart beat signal recorded simultaneously with rsfMRI data. However, how effective this method is, particularly in animal models, has not been fully evaluated. Here we propose a study that manipulates the heart rate during rsfMRI scan using glycopyrrolate or atenolol. We will estimate how robust RSFC quantification is in a large range of heart rate changes with the conventional data preprocessing approach. Successful completion of this study can provide important evidence to confirm the reliability of RSFC.

Group Research Website »

Summer Translational Cardiovascular Science Institute (STCSI)

Contact Information

  • Keefe Manning, Ph.D.
    Associate Professor of Biomedical Engineering and Surgery
  • Jim Pawelczyk, Ph.D.
    Associate Professor of Physiology and Kinesiology

REU Faculty Research Projects

  • Application deadline is March 1, 2019


The Department of Biomedical Engineering administers the undergraduate major in biomedical engineering, and is a part of the university-wide Intercollege Graduate Degree Program, offering both M.S. and Ph.D. degrees in Bioengineering. Our work combines traditional engineering principles with medicine and technology for the betterment of human health and society. 

Department of Biomedical Engineering

122 Chemical and Biomedical Engineering Building

The Pennsylvania State University

University Park, PA 16802-4400

Phone: 814-863-6614