Greg Shearer

Eicosapentaenoic acid prevents cardiac fibrosis via activation of free fatty acid receptor 4 in a mouse model of hypertensive heart disease; implications for heart failure preserved ejection fraction

Project Description: Heart failure with preserved ejection fraction is an emerging form of heart failure this is characterized by a stiffening wall and impaired relaxation. It is more prevalent in women, it is overtaking the classic mode of declining muscle strength, and there are no effective therapies. Our studies show that an omega-3 fatty acid known as EPA is an effective therapy because it blocks the signals which activate fiber-producing cells, thereby preventing the heart muscle from stiffening. We use both animal models and human populations to investigate this process.

About Dr. Shearer »

Summer Translational Cardiovascular Science Institute (STCSI)

Contact Information

  • Keefe Manning, Ph.D.
    Associate Professor of Biomedical Engineering and Surgery
  • Jim Pawelczyk, Ph.D.
    Associate Professor of Physiology and Kinesiology

REU Faculty Research Projects

  • Application deadline is March 1, 2019


The Department of Biomedical Engineering administers the undergraduate major in biomedical engineering, and is a part of the university-wide Intercollege Graduate Degree Program, offering both M.S. and Ph.D. degrees in Bioengineering. Our work combines traditional engineering principles with medicine and technology for the betterment of human health and society. 

Department of Biomedical Engineering

122 Chemical and Biomedical Engineering Building

The Pennsylvania State University

University Park, PA 16802-4400

Phone: 814-863-6614