Photo of Pak Kin Wong

Pak Kin Wong

Professor of Biomedical Engineering and Mechanical Engineering
One-Year Master of Science Program Coordinator

Affiliation(s):

  • Biomedical Engineering
  • Mechanical Engineering

516 Chemical and Biomedical Engineering Building

pxw28@psu.edu

814-863-5267

Personal or Departmental Website

Research Areas:

Cell and Molecular Bioengineering; Tissue Engineering and Regenerative Medicine

 
 

 

Education

  • MS, University of California, Los Angeles, 2002
  • Ph D, Mechanical Engineering, University of California, Los Angeles, 2005

Publications

Journal Articles

  • Ninghao Zhu, Mona Ahmed, Joseph Liao and Pak Kin Wong, 2023, "Long Noncoding RNA MALAT1 is Dynamically Regulated in Leader Cells during Collective Cancer Invasion", Proceedings of the National Academy of Sciences of the United States of America, 120
  • Yang Song, Jennifer Soto, Binru Chen, Tyler Hoffman, Weikang Zhao, Weikang Zhao, Ninghao Zhao, Qin Peng, Pak Kin Wong, Longwei Liu, Chau Ly, Yingxiao Wang, AMy Rowat, Siavash Kurdistani and Song Li, 2022, "Transient nuclear deformation primes epigenetic state and promotes cell reprogramming", Nature Materials, 21, pp. 9
  • Sam Vilchez Mercedes, F Bocci, H Levine, J. N. Onuchic, M K Jolly and Pak Kin Wong, 2021, "Decoding leader cells in collective cancer invasion", Nature Reviews Cancer, 21
  • H Li, E Shkolyar, S Conti, AC Pao, JC Liao, TS Wong and Pak Kin Wong, 2020, "SLIPS-LAB—A bioinspired bioanalysis system for metabolic evaluation of urinary stone disease", Science Advances
  • H Li, P Torab and Pak Kin Wong, 2020, "Detection of bacterial infection via a fidget spinner", Nature Biomedical Engineering
  • K E Mach, A M Kaushik, K Hsieh, Pak Kin Wong, T.-H. Wang and J C Liao, 2019, "Optimizing Peptide Nucleic Acid Probes for Hybridization-based Detection and Identification of Bacterial Pathogens", Analyst
  • Y Wan, N Zhu, Y Lu and Pak Kin Wong, 2019, "A DNA Transformer for Visualizing Endogenous RNA Dynamics in Live Cells", Analytical Chemistry
  • Jian Gao, Hui Li, Peter Torab, Kathleen Mach, David Craft, Neal Thomas, Chris Puleo, Joseph Liao, Tza-Huei Wang and Pak Kin Wong, 2019, "Nanotube Assisted Microwave Electroporation for Single Cell Pathogen Identification and Antimicrobial Susceptibility Testing", Nanomedicine: Nanotechnology, Biology, and Medicine
  • Zach S Dean, Nima Jamilpour, Marvin Slepian and Pak Kin Wong, 2019, "Decreasing Wound Edge Stress Enhances Leader Cell Formation during Collective Smooth Muscle Cell Migration", ACS Biomaterials Science and Engineering
  • Nima Jamilpour, Kihwan Nam, Carol Gregorio and Pak Kin Wong, 2019, "Probing Collective Mechanoadaptation in Cardiomyocyte Development by Plasma Lithography Patterned Elastomeric Substrates", ACS Biomaterials Science and Engineering
  • F Bocci, S Tripathi, S Mercedes, J George, Pak Kin Wong, J Casabar, S M Hanash, H Levine, J N Onuchic and M K Jolly, 2019, "NRF2 activates a partial Epithelial-Mesenchymal Transition and is maximally present in a hybrid Epithelial/Mesenchymal phenotype", Integrative Biology
  • Hironobu Yamashita, Yuka Kawasawa, Lauren Shuman, Zongyu Zheng, Truc Tran, Vonn Walter, Joshua Warrick, Guoli Chen, Hikmat Al-Ahmadie, Matthew Kaag, Pak Kin Wong, Jay Raman and David DeGraff, 2019, "Repression of Transcription Factor AP-2 Alpha by PPAR? Reveals a Novel Transcriptional Circuit in Basal-squamous Bladder Cancer", Oncogenesis
  • Hui Li, Peter Torab, Kathleen Mach, Christine Surrette, Matthew England, David Craft, Neal Thomas, Joseph Liao, Chris Puleo and Pak Kin Wong, 2019, "Adaptable microfluidic system for single-cell pathogen classification and antimicrobial susceptibility testing", Proceedings of the National Academy of Sciences of the United States of America
  • Jing Wang, Lin Wang, Nan Sun, Ross Tierney, Hui Li, Margo Corsetti, Leon Williams, Pak Kin Wong and Tak Sing Wong, 2019, "Viscoelastic solid-repellent coatings for extreme water saving and global sanitation", Nature Sustainability
  • Hui Li, Michael Morowitz, Neal Thomas and Pak Kin Wong, 2019, "Rapid Single Cell Microbiological Analysis – Toward Precision Management of Infections and Dysbiosis", SLAS Technology
  • Y Xiao, R Riahi, Peter Torab, Donna Zhang and Pak Kin Wong, 2019, "Collective Cell Migration in 3D Epithelial Wound Healing", ACS NANO
  • Y Sun, D.-H. Kim and Pak Kin Wong, 2018, "Advancing Mechanobiology by Micro/Nanosystems", IEEE Transactions on Nanotechnology
  • M Dodson, M Rojo de la Vega, B Harder, R Castro-Portuguez, S. D. Rodrigues, Pak Kin Wong, E Chappman and D Zhang, 2018, "Low-level arsenic causes proteotoxic stress and not oxidative stress", Toxicology and Applied Pharmacology
  • C Surrette, B. Scherer, A Corwin, G Grossmann, A M Kaushik, K. Ksieh, P Zhang, J C Liao, Pak Kin Wong, T H Wang and C M Puleo, 2018, "Rapid Microbiology Screening in Pharmaceutical Workflows", SLAS Technology
  • Z Wang and Pak Kin Wong, 2018, "Development of DNA Pair Biosensor for Quantization of Nuclear Factor Kappa B", Biosensors
  • G B Kim, Y Cheng, W. Kang, J Guo, R Payne, H Li, Q Wei, J Baker, C Dong, S Zhang, Pak Kin Wong, E B Rizk, J Yan and J Yang, 2018, "The critical chemical and mechanical regulation of folic acid on neural engineering", Biomaterials
  • M Dodson, P Liu, T Jiang, A J Ambrose, G Luo, M Rojo de la Vega, A B Cholanians, Pak Kin Wong, E Chapman and D D Zhang, 2018, "Increased O-GlcNAcylation of SNAP29 Drives Arsenic-Induced Autophagic Dysfunction", Molecular and Cellular Biology
  • Hui Li, Yi Lu and Pak Kin Wong, 2018, "Diffusion-reaction kinetics of microfluidic amperometric biosensors", Lab on a Chip
  • S Wang, Y Xiao, D D Zhang and Pak Kin Wong, 2018, "A Gapmer Aptamer Nanobiosensor for Real-time Monitoring of Transcription and Translation in Single Cells", Biomaterials
  • N Jamilpour, K-H Nam, C Gregorio and Pak Kin Wong, 2018, "Probing Collective Mechanoadaptation in Cardiomyocyte Development by Plasma Lithography Patterned Elastomeric Substrates", ACS Biomaterials Science and Engineering
  • Pak Kin Wong, Shue Wang, Jian Sun, Yuan Xiao, Yi Lu and Donna Zhang, 2017, "Intercellular Tension Negatively Regulates Angiogenic Sprouting of Endothelial Tip Cells via Notch1-Dll4 Signaling", Advanced Biosystems
  • Pak Kin Wong, E Altobelli, R Mohan, K E Mach, M. L. Y. Sin, V Anikst, M Buscarini, V Gau, N Banaei and J Liao, 2017, "Integrated Biosensor Assay for Rapid Uropathogen Identification and Phenotypic Antimicrobial Susceptibility Testing", European Urology Focus
  • Jian Gao, Lindsie Jeffries, Kathleen Mach, David Craft, Neal Thomas, Vincent Gau, Joseph Liao and Pak Kin Wong, 2017, "A Multiplex Electrochemical Biosensor for Bloodstream Infection Diagnosis", SLAS Technology
  • Shue Wang, Jian Sun, Donna D Zhang, Pak Kin W andng, , 2016, "A Nanobiosensor for Dynamic Single Cell Analysis during Microvascular Self-Organization", Nanoscale, 8, pp. 8
  • Zach S. Dean, Paul Elias, Nima Jamilpour, Urs Utzinger and Pak Kin Wong, 2016, "Probing 3D collective cancer invasion using double-stranded locked nucleic acid biosensors", Analytical Chemistry
  • Pak Kin Wong, Jian Sun, James Hoying, Pierre Deymier and Donna D Zhang, 2016, "Cellular Architecture Regulates Collective Calcium Signaling and Cell Contractility", Plos Computational Biology, 12, pp. e1004955
  • Pak Kin Wong, Emanuela Altobelli, Ruchika Mohan, Kathleen E. Mach, Mandy Sin, Victoria Anikst, Maurizio Buscarini, Vincent Gau, Niaz Banaei and Joseph Liao, 2016, "Integrated Biosensor Assay for Rapid Uropathogen Identification and Phenotypic Antimicrobial Susceptibility Testing", European Urology Focus
  • Pak Kin Wong, Yuan Xiao, Yi Lu, Michael Hsieh and Joseph Liao, 2016, "A Microfiltration Device for Urogenital Schistosomiasis Diagnostics", PLoS One, 11, pp. e0154640
  • Pak Kin Wong, Qi Tang, Min Liang, Yi Lu, Gerald Wilmink, Donna D Zhang and Hao Xin, 2016, "Microfluidic Devices for Terahertz Spectroscopy of Live Cells Toward Lab-on-a-Chip Applications", Sensors, 16, pp. 476
  • Min Long, de la Vega, Montserrat Rojo, Qing Wen, Manish Bharara, Tao Jiang, Rui Zhang, Shiwen Zhou, Pak Kin Wong, Georg T. Wondrak, Hongting Zheng and Donna D. Zhang, 2016, "An Essential Role of NRF2 in Diabetic Wound Healing", Diabetes, 65, (3), pp. 780-793
  • Yongliang Yang, Nima Jamilpour, Baoyin Yao, Zachary S. Dean, Reza Riahi and Pak Kin Wong, 2016, "Probing Leader Cells in Endothelial Collective Migration by Plasma Lithography Geometric Confinement", Scientific Reports, 6
  • Tao Shen, Tao Jiang, Min Long, Jun Chen, Dong-Mei Ren, Pak Kin Wong, Eli Chapman, Bo Zhou and Donna D. Zhang, 2015, "A Curcumin Derivative That Inhibits Vinyl Carbamate-Induced Lung Carcinogenesis via Activation of the Nrf2 Protective Response", Antioxidants & Redox Signaling, 23, (8), pp. 651-664
  • Yi Lu, Dominique Macias, Zachary S. Dean, Nicole R. Kreger and Pak Kin Wong, 2015, "A UAV-Mounted Whole Cell Biosensor System for Environmental Monitoring Applications", Ieee Transactions on Nanobioscience, 14, (8), pp. 811-817
  • Yi Lu, Tingting Liu, Ariana C. Lamanda, Mandy L. Y. Sin, Vincent Gau, Joseph C. Liao and Pak Kin Wong, 2015, "AC Electrokinetics of Physiological Fluids for Biomedical Applications", Jala, 20, (6), pp. 611-620
  • Jian Sun, Yuan Xiao, Shue Wang, Marvin J. Slepian and Pak Kin Wong, 2015, "Advances in Techniques for Probing Mechanoregulation of Tissue Morphogenesis", Jala, 20, (2), pp. 127-137
  • Kaitlyn R. Ammann, Katrina J. DeCook, Phat L. Tran, Valerie M. Merkle, Pak Kin Wong and Marvin J. Slepian, 2015, "Collective cell migration of smooth muscle and endothelial cells: impact of injury versus non-injury stimuli", Journal of Biological Engineering, 9
  • Kathleen E. Mach, Ruchika Mohan, Shailja Patel, Pak Kin Wong, Michael Hsieh and Joseph C. Liao, 2015, "Development of a Biosensor-Based Rapid Urine Test for Detection of Urogenital Schistosomiasis", Plos Neglected Tropical Diseases, 9, (7)
  • Christopher T. Pappas, Rachel M. Mayfield, Christine Henderson, Nima Jamilpour, Cathleen Cover, Zachary Hernandez, Kirk R. Hutchinson, Miensheng Chu, Ki-Hwan Nam, Jose M. Valdez, Pak Kin Wong, Henk L. Granzier and Carol C. Gregorio, 2015, "Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality", Proceedings of the National Academy of Sciences of the United States of America, 112, (44), pp. 13573-13578
  • Reza Riahi, Jian Sun, Shue Wang, Min Long, Donna D. Zhang and Pak Kin Wong, 2015, "Notch1-Dll4 signalling and mechanical force regulate leader cell formation during collective cell migration", Nature Communications, 6
  • Tongde Wu, Bryan G. Harder, Pak Kin Wong, Julie E. Lang and Donna D. Zhang, 2015, "Oxidative stress, mammospheres and Nrf2-new implication for breast cancer therapy?", Molecular Carcinogenesis, 54, (11), pp. 1494-1502
  • Tao Jiang, Bryan Harder, de la Vega, Montserrat Rojo, Pak Kin Wong, Eli Chapman and Donna D. Zhang, 2015, "p62 links autophagy and Nrf2 signaling", Free Radical Biology and Medicine, 88, pp. 199-204
  • Shue Wang, Reza Riahi, Na Li, Donna D. Zhang and Pak Kin Wong, 2015, "Single Cell Nanobiosensors for Dynamic Gene Expression Profiling in Native Tissue Microenvironments", Advanced Materials, 27, (39), pp. 6034-6038
  • Zachary S. Dean, Reza Riahi and Pak Kin Wong, 2015, "Spatiotemporal dynamics of microRNA during epithelial collective cell migration", Biomaterials, 37, pp. 156-163
  • Meichei Wang Kadlec, David You, Joseph C. Liao and Pak Kin Wong, 2014, "A Cell Phone-Based Microphotometric System for Rapid Antimicrobial Susceptibility Testing", Jala, 19, (3), pp. 258-266
  • R. Riahi, Y. L. Yang, H. Kim, L. Jiang, Pak Kin Wong and Y. Zohar, 2014, "A microfluidic model for organ-specific extravasation of circulating tumor cells", Biomicrofluidics, 8, (2)
  • Mandy L. Y. Sin, Kathleen E. Mach, Pak Kin Wong and Joseph C. Liao, 2014, "Advances and challenges in biosensor-based diagnosis of infectious diseases", Expert Review of Molecular Diagnostics, 14, (2), pp. 225-244
  • Tingting Liu, Mandy L. Y. Sin, Jeff D. Pyne, Vincent Gau, Joseph C. Liao and Pak Kin Wong, 2014, "Electrokinetic stringency control in self-assembled monolayer-based biosensors for multiplex urinary tract infection diagnosis", Nanomedicine-Nanotechnology Biology and Medicine, 10, (1), pp. 159-166
  • Jian Sun, Nima Jamilpour, Fei-Yue Wang and Pak Kin Wong, 2014, "Geometric control of capillary architecture via cell-matrix mechanical interactions", Biomaterials, 35, (10), pp. 3273-3280
  • Tongde Wu, Fei Zhao, Beixue Gao, Can Tan, Naoko Yagishita, Toshihiro Nakajima, Pak Kin Wong, Eli Chapman, Deyu Fang and Donna D. Zhang, 2014, "Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis", Genes & Development, 28, (7), pp. 708-722
  • Reza Riahi, Shue Wang, Min Long, Na Li, Pei-Yu Chiou, Donna D. Zhang and Pak Kin Wong, 2014, "Mapping Photothermally Induced Gene Expression in Living Cells and Tissues by Nanorod-Locked Nucleic Acid Complexes", Acs Nano, 8, (4), pp. 3597-3605
  • Shasha Tao, Shue Wang, Seyed Javad Moghaddam, Aikseng Ooi, Eli Chapman, Pak Kin Wong and Donna D. Zhang, 2014, "Oncogenic KRAS Confers Chemoresistance by Upregulating NRF2", Cancer Research, 74, (24), pp. 7430-7441
  • Ki-Hwan Nam, Nima Jamilpour, Etienne Mfoumou, Fei-Yue Wang, Donna D. Zhang and Pak Kin Wong, 2014, "Probing Mechanoregulation of Neuronal Differentiation by Plasma Lithography Patterned Elastomeric Substrates", Scientific Reports, 4
  • Tingting Liu, Yi Lu, Vincent Gau, Joseph C. Liao and Pak Kin Wong, 2014, "Rapid Antimicrobial Susceptibility Testing with Electrokinetics Enhanced Biosensors for Diagnosis of Acute Bacterial Infections", Annals of Biomedical Engineering, 42, (11), pp. 2314-2321
  • Reza Riahi, Min Long, Yongliang Yang, Zachary Dean, Donna D. Zhang, Marvin J. Slepian and Pak Kin Wong, 2014, "Single cell gene expression analysis in injury-induced collective cell migration", Integrative Biology, 6, (2), pp. 192-202
  • M. W. Kadlec, D. You, Jingang Liao and Pak Kin Wong, 2013, "A Cell Phone-Based Microphotometric System for Rapid Antimicrobial Susceptibility Testing", J Lab Autom
  • Mengxing Ouyang, Ruchika Mohan, Yi Lu, Tingting Liu, Kathleen E. Mach, Mandy L. Y. Sin, Mason McComb, Janhvi Joshi, Vincent Gau, Pak Kin Wong and Joseph C. Liao, 2013, "An AC electrokinetics facilitated biosensor cassette for rapid pathogen identification", Analyst, 138, (13), pp. 3660-3666
  • R Riahi, Z Dean, TH Wu, MA Teitell, PY Chiou, DD Zhang and PK Wong, 2013, "Detection of mRNA in living cells by double-stranded locked nucleic acid probes", Analyst, 138, (17), pp. 4777-4785
  • M.L.Y. Sin, V. Gau, J.C. Liao and P.K. Wong, 2013, "Integrated microfluidic systems for molecular diagnostics: a universal electrode platform for rapid diagnosis of urinary tract infections", IEEE Nanotechnology Magazine, 7, (1), pp. 31-7
  • Fei-Yue Wang and Pak Kin Wong, 2013, "Intelligent Systems and Technology for Integrative and Predictive Medicine: An ACP Approach", Acm Transactions on Intelligent Systems and Technology, 4, (2)
  • Michael Junkin, Yi Lu, Juexuan Long, Pierre A. Deymier, James B. Hoying and Pak Kin Wong, 2013, "Mechanically induced intercellular calcium communication in confined endothelial structures", Biomaterials, 34, (8), pp. 2049-2056
  • Yong Lu, J Gao, DD Zhang, V Gau, JC Liao and PK Wong, 2013, "Single Cell Antimicrobial Susceptibility Testing by Confined Microchannels and Electrokinetic Loading", Analytical Chemistry, 85, (8), pp. 3971-3976
  • Shasha Tao, Yi Zheng, Alexandria Lau, Melba C. Jaramillo, Binh T. Chau, R. Clark Lantz, Pak Kin Wong, Georg T. Wondrak and Donna D. Zhang, 2013, "Tanshinone I Activates the Nrf2-Dependent Antioxidant Response and Protects Against As(III)-Induced Lung Inflammation In Vitro and In Vivo", Antioxidants & Redox Signaling, 19, (14), pp. 1647-1661
  • M.L.Y. Sin, V. Gau, J.C. Liao and P.K. Wong, 2012, "A universal electrode approach for automated electrochemical detection of bacterial 16S rRNA", 2012 IEEE 6th International Conference on Nano/Molecular Medicine and Engineering (NANOMED 2012). Proceedings, pp. 96-100
  • Reza Riahi, Yongliang Yang, Donna D. Zhang and Pak Kin Wong, 2012, "Advances in Wound-Healing Assays for Probing Collective Cell Migration", Jala, 17, (1), pp. 59-65
  • Juexuan Long, Michael Junkin, Pak Kin Wong, James Hoying and Pierre Deymier, 2012, "Calcium Wave Propagation in Networks of Endothelial Cells: Model-based Theoretical and Experimental Study", Plos Computational Biology, 8, (12)
  • Jian Gao, Reza Riahi, Mandy L. Y. Sin, Shufeng Zhang and Pak Kin Wong, 2012, "Electrokinetic focusing and separation of mammalian cells in conductive biological fluids", Analyst, 137, (22), pp. 5215-5221
  • Mandy L. Y. Sin, Tingting Liu, Jeffrey D. Pyne, Vincent Gau, Joseph C. Liao and Pak Kin Wong, 2012, "In Situ Electrokinetic Enhancement for Self-Assembled-Monolayer-Based Electrochemical Biosensing", Analytical Chemistry, 84, (6), pp. 2702-2707
  • Kathleen E. Mach, Ruchika Mohan, Ellen Jo Baron, Mei-Chiung Shih, Vincent Gau, Pak Kin Wong and Joseph C. Liao, 2011, "A Biosensor Platform for Rapid Antimicrobial Susceptibility Testing Directly From Clinical Samples", Journal of Urology, 185, (1), pp. 148-153
  • Kathleen E. Mach, Pak Kin Wong and Joseph C. Liao, 2011, "Biosensor diagnosis of urinary tract infections: a path to better treatment?", Trends in Pharmacological Sciences, 32, (6), pp. 330-336
  • Michael Junkin, Siu Ling Leung, Samantha Whitman, Carol C. Gregorio and Pak Kin Wong, 2011, "Cellular self-organization by autocatalytic alignment feedback", Journal of Cell Science, 124, (24), pp. 4213-4220
  • Ruchika Mohan, Kathleen E. Mach, Moran Bercovici, Ying Pan, Lakshmi Dhulipala, Pak Kin Wong and Joseph C. Liao, 2011, "Clinical Validation of Integrated Nucleic Acid and Protein Detection on an Electrochemical Biosensor Array for Urinary Tract Infection Diagnosis", Plos One, 6, (10)
  • Yongliang Yang, Justin Volmering, Michael Junkin and Pak Kin Wong, 2011, "Comparative assembly of colloidal quantum dots on surface templates patterned by plasma lithography", Soft Matter, 7, (21), pp. 10085-10090
  • Jian Gao, Mandy L. Y. Sin, Tingting Liu, Vincent Gau, Joseph C. Liao and Pak Kin Wong, 2011, "Hybrid electrokinetic manipulation in high-conductivity media", Lab on a Chip, 11, (10), pp. 1770-1775
  • Seokheun Choi, Michael Goryll, Lai Yi Mandy Sin, Pak Kin Wong and Junseok Chae, 2011, "Microfluidic-based biosensors toward point-of-care detection of nucleic acids and proteins", Microfluidics and Nanofluidics, 10, (2), pp. 231-247
  • Reza Riahi, Kathleen E. Mach, Ruchika Mohan, Joseph C. Liao and Pak Kin Wong, 2011, "Molecular Detection of Bacterial Pathogens Using Microparticle Enhanced Double-Stranded DNA Probes", Analytical Chemistry, 83, (16), pp. 6349-6354
  • Michael Junkin and Pak Kin Wong, 2011, "Probing cell migration in confined environments by plasma lithography", Biomaterials, 32, (7), pp. 1848-1855
  • Hongting Zheng, Samantha A. Whitman, Wei Wu, Georg T. Wondrak, Pak Kin Wong, Deyu Fang and Donna D. Zhang, 2011, "Therapeutic Potential of Nrf2 Activators in Streptozotocin-Induced Diabetic Nephropathy", Diabetes, 60, (11), pp. 3055-3066
  • Chia Hsiang Chen, Yi Lu, Mandy L. Y. Sin, Kathleen E. Mach, Donna D. Zhang, Vincent Gau, Joseph C. Liao and Pak Kin Wong, 2010, "Antimicrobial Susceptibility Testing Using High Surface-to-Volume Ratio Microchannels", Analytical Chemistry, 82, (3), pp. 1012-1019
  • Ying Pan, Geoffrey A. Sonn, Mandy L. Y. Sin, Kathleen E. Mach, Mei-Chiung Shih, Vincent Gau, Pak Kin Wong and Joseph C. Liao, 2010, "Electrochemical immunosensor detection of urinary lactoferrin in clinical samples for urinary tract infection diagnosis", Biosensors & Bioelectronics, 26, (2), pp. 649-654
  • Mandy L. Y. Sin, Vincent Gau, Joseph C. Liao and Pak Kin Wong, 2010, "Electrothermal Fluid Manipulation of High-Conductivity Samples for Laboratory Automation Applications", Jala, 15, (6), pp. 426-432
  • May L. Chiu, Walson Lawi, Steven T. Snyder, Pak Kin Wong, Joseph C. Liao and Vincent Gau, 2010, "Matrix Effects-A Challenge Toward Automation of Molecular Analysis", Jala, 15, (3), pp. 233-242
  • Chia Hsiang Chen, Vincent Gau, Donna D. Zhang, Joseph C. Liao, Fei-Yue Wang and Pak Kin Wong, 2010, "Statistical Metamodeling for Revealing Synergistic Antimicrobial Interactions", Plos One, 5, (11)
  • Na Li and Pak Kin Wong, 2010, "Transfection of molecular beacons in microchannels for single-cell gene-expression analysis", Bioanalysis, 2, (10), pp. 1689-1699
  • Tza-Huei Wang and Pak Kin Wong, 2010, "Transforming Microfluidics into Laboratory Automation", Jala, 15, (3), pp. A15-A16
  • Walson Lawi, Chris Wiita, Steven T. Snyder, Fang Wei, David Wong, Pak Kin Wong, Joseph C. Liao, David Haake and Vincent Gau, 2009, "A Microfluidic Cartridge System for Multiplexed Clinical Analysis", Jala, 14, (6), pp. 407-412
  • Mandy L. Y. Sin, Vincent Gau, Joseph C. Liao, David A. Haake and Pak Kin Wong, 2009, "Active Manipulation of Quantum Dots using AC Electrokinetics", Journal of Physical Chemistry C, 113, (16), pp. 6561-6565
  • Jungkyu Kim, Michael Junkin, Deok-Ho Kim, Seunglee Kwon, Young Shik Shin, Pak Kin Wong and Bruce K. Gale, 2009, "Applications, techniques, and microfluidic interfacing for nanoscale biosensing", Microfluidics and Nanofluidics, 7, (2), pp. 149-167
  • Joseph Keyes, Michael Junkin, Pak Kin Wong and Jonathan P. Vande Geest, 2009, "Computational simulation of a magnetic microactuator for tissue engineering applications", Biomedical Microdevices, 11, (6), pp. 1259-1267
  • Mandy L. Y. Sin, Yusuke Shimabukuro and Pak Kin Wong, 2009, "Hybrid electrokinetics for separation, mixing, and concentration of colloidal particles", Nanotechnology, 20, (16)
  • Vinay Gidwani, Reza Riahi, Donna D. Zhang and Pak Kin Wong, 2009, "Hybridization kinetics of double-stranded DNA probes for rapid molecular analysis", Analyst, 134, (8), pp. 1675-1681
  • Deok-Ho Kim, Pak Kin Wong, Jungyul Park, Andre Levchenko and Yu Sun, 2009, "Microengineered Platforms for Cell Mechanobiology", Annual Review of Biomedical Engineering, 11, pp. 203-233
  • Fei Zhao, Tongde Wu, Alexandria Lau, Tao Jiang, Zheping Huang, Xiao-Jun Wang, Weimin Chen, Pak Kin Wong and Donna D. Zhang, 2009, "Nrf2 promotes neuronal cell differentiation", Free Radical Biology and Medicine, 47, (6), pp. 867-879
  • Michael Junkin, Jennifer Watson, Jonathan P. Vande Geest and Pak Kin Wong, 2009, "Template-Guided Self-Assembly of Colloidal Quantum Dots Using Plasma Lithography", Advanced Materials, 21, (12), pp. 1247-+
  • Daniel Meserve, Zhaohui Wang, Donna D. Zhang and Pak Kin Wong, 2008, "A double-stranded molecular probe for homogeneous nucleic acid analysis", Analyst, 133, (8), pp. 1013-1019
  • Pak Kin Wong, Fuqu Yu, Arash Shahangian, Genhong Cheng, Ren Sun and Chih-Ming Ho, 2008, "Closed-loop control of cellular functions using combinatory drugs guided by a stochastic search algorithm", Proceedings of the National Academy of Sciences of the United States of America, 105, (13), pp. 5105-5110
  • Alexandria Lau, Nicole F. Villeneuve, Zheng Sun, Pak Kin Wong and Donna D. Zhang, 2008, "Dual roles of Nrf2 in cancer", Pharmacological Research, 58, (5-6), pp. 262-270
  • Joseph Keyes, Michael Junkin, Joseph Cappello, Xiaoyi Wu and Pak Kin Wong, 2008, "Evaporation-induced assembly of biomimetic polypeptides", Applied Physics Letters, 93, (2)
  • Xiao-Jun Wang, Zheng Sun, Nicole F. Villeneuve, Shirley Zhang, Fei Zhao, Yanjie Li, Weimin Chen, Xiaofang Yi, Wenxin Zheng, Georg T. Wondrak, Pak Kin Wong and Donna D. Zhang, 2008, "Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2", Carcinogenesis, 29, (6), pp. 1235-1243
  • Yu Du, Nicole F. Villeneuve, Xiao-Jun Wang, Zheng Sun, Weimin Chen, Jixue Li, Hongxiang Lou, Pak Kin Wong and Donna D. Zhang, 2008, "Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response", Environmental Health Perspectives, 116, (9), pp. 1154-1161
  • Zhaohui Wang, Vinay Gidwani, Donna D. Zhang and Pak Kin Wong, 2008, "Separation-free detection of nuclear factor kappa B with double-stranded molecular probes", Analyst, 133, (8), pp. 998-1000
  • PK Wong, W Tan and CM Ho, 2005, "Cell relaxation after electrodeformation: effect of latrunculin A on cytoskeletal actin", Journal of Biomechanics, 38, (3), pp. 529-535
  • TH Wang, YH Peng, CY Zhang, PK Wong and CM Ho, 2005, "Single-molecule tracing on a fluidic microchip for quantitative detection of low-abundance nucleic acids", Journal of the American Chemical Society, 127, (15), pp. 5354-5359
  • PK Wong, CY Chen, TH Wang and CM Ho, 2004, "Electrokinetic bioprocessor for concentrating cells and molecules", Analytical Chemistry, 76, (23), pp. 6908-6914
  • PK Wong, TH Wang, JH Deval and CM Ho, 2004, "Electrokinetics in micro devices for biotechnology applications", Ieee-Asme Transactions on Mechatronics, 9, (2), pp. 366-376
  • PK Wong, U Ulmanella and CM Ho, 2004, "Fabrication process of microsurgical tools for single-cell trapping and intracytoplasmic injection", Journal of Microelectromechanical Systems, 13, (6), pp. 940-946
  • TK Hsiai, SK Cho, PK Wong, MH Ing, A Salazar, S Hama, M Navab, LL Demer and H Chih-Ming, 2004, "Micro sensors: Linking real-time oscillatory shear stress with vascular inflammatory responses", Annals of Biomedical Engineering, 32, (2), pp. 189-201
  • PK Wong, YK Lee and CM Ho, 2003, "Deformation of DNA molecules by hydrodynamic focusing", Journal of Fluid Mechanics, 497, pp. 55-65
  • TK Hsiai, SK Cho, PK Wong, M Ing, A Salazar, A Sevanian, M Navab, LL Demer and CM Ho, 2003, "Monocyte recruitment to endothelial cells in response to oscillatory shear stress", Faseb Journal, 17, (12), pp. 1648-1657
  • E. M. K. K. Hewage, D Spear, T.M. Umstead, S Hu, M Wang, Pak Kin Wong, Z. C. Chroneos, E S Halstead and N J Thomas, , "An Electrochemical Biosensor for Rapid Detection of Pediatric Bloodstream Infections”, SLAS Technology", SLAS Technology
  • M Chu, S Novak, C Cover, A Wang, I Chinyere, E Juneman, D Zarnescu, Pak Kin Wong and C C Gregorio, , "Increased cardiac arrhythmogenesis associated with gap junction remodeling with upregulation of RNA binding protein FXR1", Circulation

Research Projects

Honors and Awards

  • Best Conference Paper, The 15th IEEE International Conference on Nano/Molecular Medicine & Engineering, 2021
  • Distinghished Alumni Award, Faculty of Engineering, The Chinese University of Hong Kong, 2017
  • CM HO Best Paper Award in Micro/Nano Fluidics, IEEE NEMS 2016 conference, 2016
  • Fellow of American Institute for Medical and Biological Engineering, American Institute for Medical and Biological Engineering, April 2017
  • Fellow of the American Society of Mechanical Engineers, American Society of Mechanical Engineers, 2021
  • Academy member, European Academy of Sciences and Arts, 2023
  • Fellow of Royal Society of Chemistry, Royal Society of Chemistry, January 2017
  • Fellow of Society for Laboratory Automation and Screening, Society for Laboratory Automation and Screening, 2017

Service

Service to Penn State:

Service to External Organizations:

  • Service to Governmental Agencies, Other, Nominator, Japan Prize Official Nominator, Japan Prize, 2020
  • Organizing Conferences and Service on Conference Committees, Chairperson, General Chair, IEEE NANOMED 2018, August 2017 - December 2018
 


 

About

The Department of Biomedical Engineering administers the bachelor of science, master of science, and doctorate degree programs in biomedical engineering. Our work combines traditional engineering principles with medicine and technology for the betterment of human health and society. 

Department of Biomedical Engineering

122 Chemical and Biomedical Engineering Building

The Pennsylvania State University

University Park, PA 16802-4400

Phone: 814-863-6614

Email: bme@engr.psu.edu